Adjuvant Therapy of Breast Cancer IV

1. Front Matter

   Pages I-XIV

   PDF

2. Biological Mechanisms and Models

   1. Kinetic Concepts in the Treatment of Breast Cancer

      • L. Norton

      Pages 1-6

   2. Tumor Stem Cells and the Curability of Early Human Breast Cancer

      • C. Jasmin

      Pages 7-12

   3. A New Paradigm for Breast Cancer

      • M. W. Retsky, D. E. Swartzendruber, P. D. Bame, R. H. Wardwell

      Pages 13-22

   4. A Laboratory Model To Explain the Survival Advantage Observed in Patients Taking Adjuvant Tamoxifen Therapy

      • D. M. Wolf, V. C. Jordan

      Pages 23-33

   5. Growth Factors and Angiogenesis in Breast Cancer

      • A. L. Harris, E. Horak

      Pages 35-41

   6. Mechanisms of Treatment Failure

      • M. H. N. Tattersall

      Pages 43-47

   7. Expression of the MDR1 Gene (P-Glycoprotein) in Breast Cancer

      • R. S. Weinstein, K. K. Hansen, R. B. McBeath, W. S. Dalton

      Pages 49-54

3. Prognosis and Prediction of Response

   1. Prognosis of Breast Cancer Patients: How To Use What?

      • G. M. Clark, W. L. McGuire

      Pages 55-60

   2. DNA Flow Cytometry Measurements and Their Clinical Relevance in Node-Negative Breast Cancer Patients

      • L. G. Dressler

      Pages 61-69

   3. Review of Proliferative Variables and Their Predictive Value

      • R. Silvestrini, M. G. Daidone

      Pages 71-76

   4. Critical Review of Growth Factors as Clinical Tools in Primary and Metastatic Breast Cancer

      • J. G. M. Klijn, P. M. J. J. Berns, W. L. J. van Putten, M. Bontenbal, J. Alexieva-Figusch, J. A. Foekens

      Pages 77-88

   5. Prognosis and Prediction for Early Breast Cancer

      • M. Baum

      Pages 89-94

4. Primary Therapy for Early Breast Cancer

   1. Trials of Breast Conservation: A Critical Review of All Options

      • W. C. Wood

      Pages 95-98

   2. Selection and Technique for Lumpectomy

      • R. G. Margolese

      Pages 99-108

   3. Salvage Treatment After Local Breast Cancer Relapse

      • F. Harder, R. Hünig, U. Laffer, N. Lüscher, R. de Roche, J. Torhorst

      Pages 109-112

   4. Primary Chemotherapy for Resectable Breast Cancer

      • G. Bonadonna, U. Veronesi, C. Brambilla, L. Ferrari, P. Passoni, G. F. Coopmans de Yoldi et al.

      Pages 113-117

5. Radiation Therapy as Part of Primary Treatment

   1. Radiation Therapies for Breast Cancer: Current Knowledge on Advantages and Disadvantages

      • L. E. Rutqvist

      Pages 119-127

   2. How To Combine Adjuvant Chemotherapy and Radiation Therapy

      • J. R. Harris, A. Recht

      Pages 129-136

   3. Factors which Predict Breast Relapse

      • J. M. Kurtz

      Pages 137-150

Advances in breast cancer research, achieved through the progress of knowledge and development of new therapies, have been translated into improved quality of care for breast cancer patients. Clinical investigations and clinical trials have made the largest contribution to the body of knowledge that finds its way to the patient. Never before during the past decades of management of breast cancer has there been such a fruitful intellectual cross-fertilization of ideas among individuals involved in the generation of hypotheses, basic research, development of drugs and treatments, conduct of clinical trials, and statistical evaluation - the results of all of which are now translated into progress in clinical care. Even issues such as the quality of life of breast cancer patients, once the domain for few, are now being openly addressed by trials and discussed in a much broader forum. The IVth International Conference on the Adjuvant Therapy of Primary Breast Cancer, also known as the st. Gallen Conference, was again attended by more than 800 scientists and clinicians interested in this broad spectrum of breast cancer research and the interactions between such diverse fields of interest and specialties as cancer pathology, molecular biology, and psychosocial oncology. This volume collects findings and conclusions presented at the conference.

• Adjuvant Chemotherapy
• Adjuvant Therapy
• Adjuvante Chemotherapie
• Adjuvante Therapie
• Breast Cancer
• Breast Conserving Surgery
• Brusterhaltende Chirurgie
• Brustkrebs
• Lebensqualität bei Brustkrebs
• Quality of Life (in Breast Cancer)
• angiogenesis
• surgery

• Department of Medicine C, Kantonsspital, St. Gallen, Switzerland

  Hans-Jörg Senn, Beat Thürlimann

• Division of Biostatistics, Dana Farber Cancer Institute, Boston, USA

  Richard D. Gelber

• Ospedale Civico, Lugano, Switzerland

  Aron Goldhirsch

Policies and ethics