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Human Apolipoprotein Mutants III

Diagnosis and Treatment

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Cesare R. Sirtori

    1. Center E. Grossi Paoletti, Institute of Pharmacological Sciences, University of Milano, Milano, Italy

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  2. Guido Franceschini

    1. Center E. Grossi Paoletti, Institute of Pharmacological Sciences, University of Milano, Milano, Italy

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  3. Bryan H. Brewer

    1. Molecular Disease Branch, National Institutes of Health, NHLBI, Bethesda, USA

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Part of the book series: Nato ASI Subseries H: (ASIH, volume 73)

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Table of contents (25 papers)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Enzymes and Apolipoproteins in the Diagnosis of Disease

    1. Lipoprotein lipase: Gene variants and coronary atherosclerosis

      • Raj K. Mattu, David J. Galton
      Pages 1-11

    2. Apolipoproteins in the Diagnosis of Disease: Cerebral and Peripheral Atherosclerosis

      • R. Fellin, G. B. Vigna
      Pages 13-20

  3. Structural and Functional Relationships in Apolipoproteins

    1. Functional Properties of Discoidal Apoprotein/Phospholipid Complexes: Cholesterol Efflux from Macrophages and Conversion by Lecithin-Cholesterol Acyl Transferase

      • M. Rosseneu, A. Devreese, B. Vanloo, J. Baert
      Pages 21-30

    2. Lipid Transport by Apolipoprotein AI: Structure and Function

      • E. L. Gong, A. V. Nichols, A. R. Tall
      Pages 31-41

    3. Characterization of Lipoprotein Particles Containing Apolipoprotein A-IV

      • G. R. Castro, N. Duverger, P. Duchateau, J. C. Fruchart
      Pages 43-52

    4. Structural and Functional Properties of Apo A-I Variants in Reconstituted HDL

      • A. Jonas, A. von Eckardstein, W. W. Mantulin, G. Assmann
      Pages 53-65

    5. Structural Domains in Human Serum Low Density Lipoprotein Apolipoprotein B100

      • Lawrence P. Aggerbeck
      Pages 67-79

    6. Crystal Structures of the Common Apolipoprotein E Variants: Insights into Functional Mechanisms

      • Mark R. Wardell, Charles Wilson, David A. Agard, Robert W. Mahley, Karl H. Weisgraber
      Pages 81-96

    7. Analysis of Apolipoprotein E Function in Adrenal Cells: Effects on Cholesterol Metabolism and Signal Transduction Pathways

      • David L. Williams, Margaret M. Prack, M. Nicosia, J. T. Gwynne, Mary E. Reyland
      Pages 97-106

  4. Animal Models in the Apolipoprotein Mutant Research

    1. Spontaneous Hypercholesterolemia in Pigs

      • Alan D. Attie, Robert J. Aiello, Scott T. Cooper, Patricia J. Uelmen
      Pages 107-112

    2. The Apolipoprotein E Cys-142 Mutant: Role in Dominant Inheritance of Type III Hyperlipoproteinemia and Expression in Transgenic Mice

      • Stanley C. Rall Jr., Yukio Horie, Sergio Fazio
      Pages 113-120

  5. Recombinant Apolipoproteins as Drugs

    1. Apolipoproteins as “Drugs”: Current Status

      • Cesare R. Sirtori
      Pages 121-133

    2. Non-Mammalian Host Systems for the Expression of Mammalian Apolipoproteins

      • S. L. Sturley, D. G. Gretch, P. D. Friesen, M. R. Culbertson, N. Beckage, A. D. Attie
      Pages 135-143

    3. Recombinant Human Proapolipoprotein A-I: Experimental Strategies for the Production of an Authentic Molecule

      • N. Moguilevsky, F. Varsalona, J.-P. Guillaume, C. Roobol, A. Bollen
      Pages 145-163

    4. The Role of HDL Apolipoproteins in Mediating HDL Receptor Binding and Intracellular Cholesterol Efflux

      • Armando J. Mendez, John F. Oram
      Pages 165-173

  6. Molecular Abnormalities of Apolipoproteins

    1. The Metabolism of Truncated Forms of Apolipoprotein B in Hypobetalipoproteinemia

      • Gustav Schonfeld, Elaine S. Krul
      Pages 175-182

    2. Apolipoprotein B: Genetic Variants Provide Insight into Structure and Function

      • Philippa Talmud, Alison Dunning, Steve Humphries
      Pages 183-194

    3. The Mutations of Apolipoprotein B Gene Causing Hypobetalipoproteinemia: Molecular and Functional Abnormalities in Apo B-87Padova

      • C. Gabelli, C. Bilato, S. Martini, G. E. Tennyson, H. B. Brewer Jr, G. Crepaldi et al.
      Pages 195-206

    4. Causes Underlying the Reduced Response to Simvastatin Treatment in Hypercholesterolemic Patients

      • Alberto Corsini, Maria Mazzotti, Tiziano Zanelli, Patrizia Uboldi, Domenico Sommariva, Franco Pazzucconi et al.
      Pages 207-229
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Keywords

About this book

Hopes to develop apolipoproteins for diagnostic or, even better, therapeuticpurposes are growing. Areas of use may range from arterial disease to AIDS, fertilization programs, neurological or inflammatory disorders, and the like. However, these young members of the large family of circulating proteins still deserve careful study, both in terms of structural and functional properties and of their pathological changes. In addition, related molecules, in particular belonging to the family of enzymes, such as lipases and acyltransferases, offer exciting insight into the mechanisms of regulation of lipid transport and exchange. Described hereis the use of apolipoproteins and enzymes in the diagnosis of coronary and cerebrovascular disease. Structural and functional changes of apolipoproteins are related to lipid transport and binding to different receptors. Further, the development of apolipoprotein drugs and their possible clinical use for vascular and non vascular disease is discussed and finally an overview on lipoprotein transformation processes, expression systems and natural mutants is provided.

Editors and Affiliations

  • Center E. Grossi Paoletti, Institute of Pharmacological Sciences, University of Milano, Milano, Italy

    Cesare R. Sirtori, Guido Franceschini

  • Molecular Disease Branch, National Institutes of Health, NHLBI, Bethesda, USA

    Bryan H. Brewer

Bibliographic Information

  • Book Title: Human Apolipoprotein Mutants III

  • Book Subtitle: Diagnosis and Treatment

  • Editors: Cesare R. Sirtori, Guido Franceschini, Bryan H. Brewer

  • Series Title: Nato ASI Subseries H:

  • DOI: https://doi.org/10.1007/978-3-642-84634-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-642-84636-6Published: 22 December 2011

  • eBook ISBN: 978-3-642-84634-2Published: 29 June 2013

  • Series ISSN: 1010-8793

  • Edition Number: 1

  • Number of Pages: XI, 291

  • Topics: Pharmacology/Toxicology, Cardiology, Biochemistry, general, Cell Biology, Human Physiology

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