Intracellular Regulation of Ion Channels

1. Front Matter

   Pages I-X

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2. Regulation of K+ Channels

   1. Front Matter

      Pages 1-1

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   2. K+ Channel Diversity

      • O. Pongs

      Pages 3-8

   3. Regulation of Voltage-Activated K+ Channels

      • Arthur M. Brown

      Pages 9-13

   4. Gating Mechanisms of Shaker Potassium Channels

      • R. Aldrich

      Pages 15-20

   5. Vaccinia Virus: A Novel Expression System for Receptors and Ion Channels

      • Andreas Karschin

      Pages 21-25

   6. Delayed Rectification in the Heart: Regulation and Physiology

      • W. M. Kwok, L. C. Freeman, J. Anumonwo, R. S. Kass

      Pages 27-42

   7. Receptor-Dependent Modulation of G Protein-Gated Muscarinic K+ Channel by Arachidonic Acid Metabolites

      • Yoshihisa Kurachi

      Pages 43-52

   8. The Na+-Activated K+ Channel in Cardiac Cells

      • E. Carmeliet, H.-N. Luk

      Pages 53-59

   9. Regulation of the ATP-Dependent K+ Channel of Muscle by ATP and pH

      • N. B. Standen, N. W. Davies, A. Pettit, P. R. Stanfield

      Pages 61-69

   10. Regulation of Cardiac ATP-Sensitive K+ Channels

       • James N. Weiss, Nagammal Venkatesh, Nicholas A. Deutsch

       Pages 71-81

   11. ATP-Sensitive K+ Channels : Molecular Pharmacology, Regulation and Role in Diseased States

       • M. Lazdunski, M. Fosset, J. De Weille, E. Honoré, C. Mourre

       Pages 83-86

3. Regulation of Ca2+ Channels

   1. Front Matter

      Pages 87-87

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   2. Tissue distribution and possible function of the subunits of the L-type calcium channels

      • F. Hofmann, M. Biel, R. Hullin, E. Bosse, V. Flockerzi

      Pages 89-97

   3. Phosphorylation and Regulation of Calcium Channels by Multiple Protein Kinases

      • M. Marlene Hosey, Rebecca M. Brawley, Chan Fong Chang, Luis Miguel Gutierrez, Cecilia Mundina-Weilenmann, Jianjie Ma et al.

      Pages 99-106

   4. Action of the GTP-binding protein Gs on cardiac Ca++ channels

      • A. Cavalié, T. J. A. Allen, W. Trautwein

      Pages 107-112

   5. Membrane-Delimited Stimulation of Heart Cell Calcium Current by ß-Adrenergic Signal-Transducing Gs Protein

      • S. Pelzer, Y. M. Shuba, L. Birnbaumer, T. F. McDonald, D. J. Pelzer

      Pages 113-127

   6. Participation of a Fast G Protein Pathway in the ß-Adrenergic Regulation of Cardiac Calcium Channels: Neither Proven nor Needed

      • R. Fischmeister, P.-F. Méry, H. C. Hartzell, G. Szabo

      Pages 129-139

   7. Kinetics of a G-Protein Mediated Action on Neuronal Ca2+ Channels

      • H. D. Lux, N. Tokutomi, F. Grassi

      Pages 141-151

   8. Identification of G-Proteins Involved in the Inhibition of Ca2+ Currents in Neuronal and Endocrine Cells

      • J. Hescheler, C. Kleuss, C. Ewel, B. Wittig, W. Rosenthal, G. Schultz

      Pages 153-159

Understanding the molecular processes by which ionic channels are regulated is central to the understanding of cellular function. Great advances in understanding these regulatory mechanisms have been recently achieved by the combination of several powerful techniques. Development of the patch clamp technique, ability to access the intracellular channels sites, and genetic manipulation of channel structure have allowed studies of channel function in native membranes. Cloning, sequencing and determining the channel structure and its subunits allows further insight into the regulatory mechanisms of channel function. In planning this symposium, we organized the scientific discussions around specific molecular topics independent of the tissue and species of origin. Clearly, the subject of ion channel regulation is multi-faceted, with a large number of very talented scientists working in the field. The NATO Symposium represented an attempt to bring together these individuals and synthesize and evaluate new ideas and experimental findings. A great deal of novel data was presented, and scientific insight into the molecular processes which regulate ionic channels was furthered. This book gives a synopsis of the scientific presentations and is organized into 3 sections. The first section deals with the diversity of K + channels and their regulation, including structure-function and mechanistic studies. Presentations dealt with the characterization and modulation of a variety ofK+ channels in cardiac and neuronal cells, including ATP­ dependent K+ channels, Na + -activated K+ channels, delayed rectifier K+ channels and the diversity of their regulation by G-proteins.

• ATP
• Calcium
• Insulin
• Regulation
• kinetics
• muscle
• neurons
• pharmacology
• phosphorylation
• physiology
• protein
• proteins
• receptor
• system
• tissue

• School of Medicine, Dept. of Physiology, University of Pennsylvania, Philadelphia, USA

  Martin Morad, Zalman Agus

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