Risk Assessment in Chemical Carcinogenesis

1. Front Matter

   Pages I-IX

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2. Risk Assessment and Management of Toxic Chemicals: The Needs and Guidelines for Developing Countries

   1. Risk Assessment and Management of Toxic Chemicals: The Needs and Guidelines for Developing Countries

      • Chulabhorn Mahidol

      Pages 1-6

3. Molecular Basis of Risk Assessment

   1. Front Matter

      Pages 7-7

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   2. Individual genetic constellations as risk factors in chemical carcinogenesis

      • H. W. Rüdiger

      Pages 9-16

   3. Mechanistic Analysis as a Tool for Carcinogen Risk Assessment

      • W. K. Lutz

      Pages 17-23

   4. Molecular Genetic Alterations such as Oncogene Activation as a Tool for the Evaluation of Risks in Chemical Carcinogenesis

      • P. H. M. Lohman, A. J. van der Eb

      Pages 24-32

   5. Initiation and Promotion — Useful Concepts for Risk Assessment?

      • Philippe Shubik

      Pages 33-37

4. Human Exposure to Chemical Carcinogens

   1. Front Matter

      Pages 39-39

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   2. Risk Assessment of Naturally Occurring Carcinogens

      • T. Sugimura, M. Nagao, K. Wakabayashi

      Pages 41-55

   3. Carcinogenic Drugs and their Relevance in Risk Assessment

      • D. Schmähl, B. Bunk

      Pages 56-63

   4. A Weight-of-Evidence Approach to Quantitative Cancer Risk Assessment: Information Analysis

      • Robert L. Sielken Jr.

      Pages 64-78

   5. Biologically Based Pharmacokinetics and Cancer Risk Assessment

      • Melvin E. Andersen

      Pages 79-92

   6. Evaluation of Epidemiologic Study Designs for the Assessment of Risk in Chemical Carcinogenesis

      • Joseph K. McLaughlin

      Pages 93-103

   7. The role of ‘negative’ and ‘nonpositive’ studies in occupational epidemiology

      • S. Hernberg

      Pages 104-112

   8. Weak Associations in Occupational Epidemiology and the Criteria for Deducing Causality

      • R. Doll

      Pages 113-122

   9. Aspects of Clinical Oncology in the Assessment in Chemical Carcinogenesis

      • J. P. Obrecht, A. Dieterle

      Pages 123-136

5. Regulations in Risk Assessment

   1. Front Matter

      Pages 137-137

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   2. Provisions on carcinogenic substances in the Federal Republic of Germany and the European Community

      • H. Klein

      Pages 139-148

   3. Regulations on Chemical Carcinogens of the Environmental Protection Agency

      • P. A. Fenner-Crisp

      Pages 149-159

   4. Regulation of Chemical Carcinogenesis in Japan

      • Yuzo Hayashi

      Pages 160-168

The essays in this book discuss the role that chemical agents in the environment play in the development of cancer. Thus, it gives information toimprove our understanding of carcinogenesis and how to prevent it. The essays were originally presented at an international symposium.

• Onkogenie
• cancer
• carcinogenesis
• kinetics
• oncogene
• oncogenes
• oncogenesis
• oncology
• pharmacokinetics
• research

• Heidelberger Akademie der Wissenschaften, Heidelberg, Germany

  Gotthard Schettler

• Institut für Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum, Heidelberg, Germany

  Thomas Klenner

Policies and ethics