Concomitant Continuous Infusion Chemotherapy and Radiation

1. Front Matter

   Pages I-XIV

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2. The Development of Chemotherapy Drugs as Radiosensitizers: an Overview

   1. The Development of Chemotherapy Drugs as Radiosensitizers: an Overview

      • C. Julian Rosenthal, Marvin Rotman

      Pages 1-9

3. Principles of Infusion Chemotherapy

   1. Front Matter

      Pages 11-11

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   2. Experimental Rationale for Continuous Infusion Chemotherapy

      • R. Brian Mitchell, Mark J. Ratain, Nicolas J. Vogelzang

      Pages 13-27

   3. Combination Chemotherapy by Infusion in Hematological Malignancies

      • Leonard Saltz, Morton Coleman, Peter Yi

      Pages 29-34

   4. Combination Chemotherapy by Infusion in Solid Tumors

      • James D. Ahlgren

      Pages 35-47

   5. Admixtures of Chemotherapy Agents by Continuous Infusion

      • Jacob J. Lokich

      Pages 49-55

   6. Time-Specified Delivery of Chemotherapy by Implantable Programmable Pumps — Preliminary Data on 5-Fluoro-2’-deoxyuridine

      • Reinhard von Roemeling, Rosellen Lanning, Henry Wagner Jr., Ronald DeConti, Lawrence E. Scheving, William Hrushesky

      Pages 57-65

   7. Advances in the Technology of Continuous Infusion

      • Jose R. Marti

      Pages 67-73

4. Radiosensitization and Radioprotection

   1. Front Matter

      Pages 75-75

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   2. Hypoxic Cell Sensitizers

      • C. Norman Coleman

      Pages 77-84

   3. Glutathione, a Determinant of Response to Cancer Treatment

      • Dwight Kaufman, James B. Mitchell, Angelo Russo

      Pages 85-89

   4. Radiosensitization of Nonhypoxic Cells by Halogenated Pyrimidines

      • Timothy J. Kinsella

      Pages 91-96

   5. Perfluorocarbon Emulsion and Oxygen with Concomitant Radiation Therapy in Primary High Grade Brain Tumors

      • Richard G. Evans, Bruce F. Kimler, Robert A. Morantz, Tribhawan S. Vats, Vici Liston, Norma L. Lowe

      Pages 97-100

   6. Chemo- and Radioprotection: Clinical Trials Combining WR-2721 with Cisplatin and Cyclophosphamide

      • Donna Glover, Clare Weiler, Stephen Grabelsky

      Pages 101-104

   7. Biological Modifiers’ Potential for Radioprotection

      • Gary B. Thurman, Robert K. Oldham

      Pages 105-111

5. 5-Fluorouracil Radiopotentiation and Its Modulation by Other Agents

   1. Front Matter

      Pages 113-113

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   2. Theoretical Basis and Clinical Applications of 5-Fluorouracil as a Radiosensitizer — an Overview

      • John E. Byfield

      Pages 115-127

   3. Efficacy of 5-Fluorouracil by Continuous Infusion as a Radiopotentiator — Anal and Rectal Carcinoma

      • Ben Sischy

      Pages 129-135

   4. Hepatic Metastases from Gastrointestinal Malignancies and Hepatocellular Carcinoma

      • Marvin Rotman, Hassan Aziz, Seth Reiner, C. Julian Rosenthal, Jean-Philippe Austin, Richard S. Stark

      Pages 137-142

The administration of chemotherapeutic agents by continuous infusion with concomitant radiation therapy heralds a new approach in the treatment of cancer. This comprehensive book on the subject includes, besides a discussion of its scientific basis, the most promising clinical data on the use of continuous infusion chemotherapy and radiation. Thus, it is an important update for clinical investigators involved in frontline research as well as for practicing physicians participating in the direct care of cancer patients. The contributions include the latest results of this new approach in a number of tumor sites. There is a detailed description of the principles of radiosensitization for malignant tumors and radioprotection for normal tissues; these are the principles which have led to concrete clinical applications. There is also a presentation of the most recent data on the beneficial effects resulting from the administration of commonly used drugs, such as 5-fluorouracil, cisplatinum and adriamycin, with concomitant radiation therapy. Much of the data has never before been published. The wealth of information in this volume makes it a valuable reference; at the same time it gives practicing physicians a detailed presentation of various therapeutic regimens which they could administer in their daily clinical practice. In the future, this innovative cancer treatment may lead to the decreased need for radical surgery and the increased ability to preserve organ function.

• Tumor
• brain
• brain tumors
• cancer
• cancer treatment
• carcinoma
• cell
• chemotherapy
• clinical trial
• metastasis
• radiation
• radiation therapy
• radiology
• radiotherapy
• surgery

• SUNY Health Science Center at Brooklyn, State University of New York, Brooklyn, USA

  Marvin Rotman, C. Julian Rosenthal

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