New Aspects in the Diagnosis and Treatment of Hodgkin’s Disease

1. Front Matter

   Pages I-XIV

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2. Pathology and Cell Biology of Hodgkin’s Disease

   1. Front Matter

      Pages 1-1

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   2. Pathology of Hodgkin’s Disease: Anything New?

      • D. H. Wright

      Pages 3-13

   3. Immunology of Hodgkin and Reed-Sternberg Cells

      • H. Stein, R. Schwarting, F. Dallenbach, D. Dienemann

      Pages 14-26

   4. DNA Gene Rearrangement Studies in Hodgkin’s Disease and Related Lymphomas: A Contribution to Their Cellular Origin

      • A. C. Feller, H. Griesser

      Pages 27-34

   5. Genetics of Hodgkin’s Lymphoma

      • C. Fonatsch, G. Gradl, J. Rademacher

      Pages 35-49

3. Hodgkin’s Disease Derived Cell Lines

   1. Front Matter

      Pages 51-51

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   2. Biology of Hodgkin Cell Lines

      • M. Schaadt, H. Burrichter, M. Pfreundschuh, E. Schell-Frederick, H. Tesch, C. Fonatsch et al.

      Pages 53-61

   3. Phenotypic and Genotypic Analysis of Two Cell Lines Derived from Hodgkin’s Disease Tissue Biopsies

      • D. B. Jones, A. J. W. Furley, J. Gerdes, M. F. Greaves, H. Stein, D. H. Wright

      Pages 62-66

   4. The Typical Reed-Sternberg Phenotype and I g Gene Rearrangement of Hodgkin’s Disease Derived Cell Line ZO Indicating a B-Cell Origin

      • S. Poppema, L. Visser, B. de Jong, M. Brinker, J. Atmosoerodjo, W. Timens

      Pages 67-74

   5. Characterization of Hodgkin’s Disease Derived Cell Line HDLM-2

      • H. G. Drexler, S. M. Gignac, A. V. Hoffbrand, B. F. Leber, J. Norton, M. S. Lok et al.

      Pages 75-82

   6. A New Hypothesis on the Cellular Origin of Reed-Sternberg and Hodgkin Cells Based on the Immunological and Molecular Genetic Analysis of the KM-H2 Line

      • H. Kamesaki, S. Fukuhara, H. Uchino, T. Nosaka

      Pages 83-90

   7. A Marker and Putative Pathoantigen of Hodgkin’s Cells

      • E. Paietta, R. J. Stockert, A. Morell, J. Racevskis, P. H. Wiernik

      Pages 91-98

4. Development in Diagnostic Procedures

   1. Front Matter

      Pages 99-99

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   2. Radiolabeled Monoclonal Antibodies Against Reed-Sternberg Cells for in Vivo Imaging of Hodgkin’s Disease by Immunoscintigraphy

      • P. Carde, M. Pfreundschuh, L. da Costa, L. Manil, J. D. Lumbroso, B. Caillou et al.

      Pages 101-111

   3. Diagnostic Strategies and Staging Procedures for Hodgkin’s Lymphoma: Bone Marrow Scintigraphy and Magnetic Resonance Imaging

      • H. Schicha, M. Franke, J. Smolorz, A. Linden, W. Waters, V. Diehl

      Pages 112-119

5. Therapeutic Strategies

   1. Front Matter

      Pages 121-121

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   2. Overviews

      1. Radiotherapy Trials in Hodgkin’s Disease

         • H. Sack

         Pages 123-131

      2. Current Status of Chemotherapy for Hodgkin’s Disease

         • P. H. Wiernik

         Pages 132-141

   3. Report on Recent and Current Clinical Trials

      1. Risk Factor Adapted Treatment of Hodgkin’s Lymphoma: Strategies and Perspectives

         • M. Loeffler, M. Pfreundschuh, U. Rühl, E. Hiller, H. Gerhartz, R. Roloff et al.

         Pages 142-162

In the field of Hodgkin's lymphoma, many new data have been collected during the last decade both on the cell of origin of this disease and on more effective therapies to cure the majority of pa­ tients even in the advanced stages. Therefore, it seems to be justi­ fied to compile these new data in a special volume of Recent Re­ sults in Cancer Research. This volume summarizes the contribu­ tions presented at the First International Symposium on Hodgkin's Disease that took place in Cologne (FRG) on October 2-3, 1988. There is little doubt that the Hodgkin and Reed-Sternberg (H and RS) cells and their variants represent the malignant population in Hodgkin's lymphoma; however, there is still a fierce debate as to the possible cell of origin of Hand RS cells. Many of the problems confounding earlier research into this question were related to the difficulty or virtual impossibility, of obtaining purified populations of Hand RS cells. Most of the recent progress stems from the establishment of permanent cell lines of Hand RS cells in culture.

• Monoclonal Antibodies
• Tumor
• biopsy
• diagnosis
• histopathology
• transplantation

• I. Medizinische Universitätsklinik Köln, Köln 41, Germany

  Volker Diehl, Michael Pfreundschuh, Markus Loeffler

Policies and ethics