Nucleic Acids and Molecular Biology

1. Front Matter

   Pages I-XI

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2. Structural Studies of DNA Through Cleavage by the Hydroxyl Radical

   • Th. D. Tullius

   Pages 1-12

3. DNase Activity of 1,10-Phenanthroline-Copper Ion

   • D. S. Sigman, A. Spassky

   Pages 13-27

4. Structure of E. Coli DNA Polymerase I, Large Fragment, and Its Functional Implications

   • L. S. Beese, T. A. Steitz

   Pages 28-43

5. Resolution of Model Holliday Junctions in Vitro

   • S. C. West

   Pages 44-55

6. Structure and Mechanism of the trp Repressor/Operator System

   • R. Q. Marmorstein, P. B. Sigler

   Pages 56-78

7. The deoR Repressor from E. coli and Its Action in Regulation-at-a-Distance

   • K. Hammer, G. Dandanell

   Pages 79-91

8. Complexities in Gene Regulation by Promoter Methylation

   • Walter Doerfler

   Pages 92-119

9. Transcriptional Regulation of Proto-Oncogene c-fos

   • P. E. Shaw, R. A. Hipskind, H. Schröter, A. Nordheim

   Pages 120-132

10. The Structural and Functional Domain Organization of the Chicken Lysozyme Gene Locus

    • A. E. Sippel, A. Stief, A. Hecht, A. Müller, M. Theisen, U. Borgmeyer et al.

    Pages 133-147

11. Mammalian Ribosomal Gene Transcription

    • I. Grummt

    Pages 148-163

12. The Chemical Synthesis of Oligo- and Poly-ribonucleotides

    • C. B. Reese

    Pages 164-181

13. RNA Structure

    • M. Delarue, D. Moras

    Pages 182-196

14. Pre-mRNA Splicing in Yeast

    • U. Vijayraghavan, J. Abelson

    Pages 197-215

15. Trans-Splicing of RNA

    • J. C. Boothroyd

    Pages 216-230

16. Structure and Function of Bacterial RNase P

    • M. Baer, N. Lumelsky, C. Guerrier-Takada, S. Altman

    Pages 231-250

17. Transposition in Plants

    • A. Gierl, H. Saedler

    Pages 251-259

18. Transgenic Plants and the Study of Plant Development

    • R. Masterson, J. Schell

    Pages 260-268

19. Back Matter

    Pages 269-272

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A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression. A number of authors address the subject of RNA, including the difficult but important subject of its chemical synthesis, the complexities of its structures and the mechanisms of transcript splicing. The probing of DNA structure is reviewed in papers on the application of hydroxyl radical and 1,10 phenanthroline copper cleavages. A number of important DNA-protein interactions are discussed, including DNA polymerase, the tryptophan and deoR repressors, and the resolvase enzymes which cleave Holliday junctions in recombination. Gene transcription is also covered, from the points of view of DNA methylation, mammalian ribosomal and avian lysozyme genes, and the control of transcription in the proto-oncogene c-fos. Finally, the plant kingdom has not been forgotten with articles on development and transposition in plants.

• DNA
• RNA
• biology
• enzymes
• gene expression
• gene transcription
• genes
• methylation
• molecular biology
• nucleic acid
• oncogene
• protein
• proteins
• synthesis
• transcription

• Abteilung Chemie, Max-Planck-Institut für experimentelle Medizin, Göttingen, Germany

  Fritz Eckstein

• Biochemistry Department, University of Dundee, Dundee, UK

  David M. J. Lilley

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