Activation and Desensitization of Transducing Pathways

1. Front Matter

   Pages I-XI

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2. Chemotaxis and chemosensing

   1. Front Matter

      Pages 1-1

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   2. Activation and Densensitization in Bacterial Chemotaxis

      • Melvin I. Simon

      Pages 3-21

   3. Adaptation of Chemoattractant Elicited Responses in Dictyostelium Discoideum

      • Roxanne Vaughan, Ronald Johnson, Michael Caterina, Peter Devreotes

      Pages 23-40

   4. The Inositolcycle of Dictyostelium Discoideum

      • Peter J. M. Van Haastert, Anthony A. Bominaar, Jeroen Van der Kaay, Richard Draijer, Louis C. Penning, Edwin Roovers et al.

      Pages 41-59

3. Cyclic nucleotide-coupled systems

   1. Front Matter

      Pages 61-61

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   2. Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

      • Miles D. Houslay, Mark Bushfield, Elaine Kilgour, Brian Lavan, Suzanne Griffiths, Nigel J. Pyne et al.

      Pages 63-83

   3. Multiple Pathways for Glucagon-Induced Heterologous Desensitization of Liver Adenylyl Cyclase

      • Richard T. Premont, Ravi Iyengar

      Pages 85-97

   4. The Mechanisms of Luteinizing Hormone-Induced Activation and Desensitization of Adenylate Cyclase

      • B. A. Cooke, D. R. E. Abayasekera, M. P. Rose

      Pages 99-113

   5. Role of Protein Kinases in the Desensitization-Sensitization of β-Adrenergic Receptor and Prostaglandin Receptor Stimulation of Adenylyl Cyclase

      • Richard B. Clark, Mark W. Kunkel, John A. Johnson, Richard Goldstein, Jacqueline Friedman

      Pages 115-131

   6. Direct Involvement of the Cyclic Nucleotide Binding Sites in the Cyclic-Nucleotide-Induced Charge Shift of Protein Kinases

      • Lynn Wolfe, Terry A. Woodford, Sharron H. Francis, Jackie D. Corbin

      Pages 133-149

4. Inositol phospholipid-cupled systems

   1. Front Matter

      Pages 151-151

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   2. Heterogeneity Amongst Myo-Inositol Derivatives: Metabolism of Second Messengers and Synthesis of Co-Signals

      • C. R. Downes, L. R. Stephens, P. T. Hawkins

      Pages 153-165

   3. Role of Glycosyl-Phosphatidylinositols in Insulin Signalling

      • Isabel Varela, Jose F. Alvarez, Jose Puerta, Rosa Clemente, Ana Guadaño, Matias Avila et al.

      Pages 167-179

   4. Agonist and Guanine Nucleotide Regulation of P2Y Purinergic Receptor-Linked Phospholipase C

      • J. L. Boyer, M. W. Martin, C. L. Cooper, G. L. Waldo, A. J. Morris, H. A. Brown et al.

      Pages 181-195

5. G-protein activation

   1. Front Matter

      Pages 197-197

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   2. Mechanisms Involved in G-protein Activation by Hormone Receptors

      • K. H. Jakobs, T. Wieland, P. Gierschik

      Pages 199-212

6. Visual transduction

   1. Front Matter

      Pages 213-213

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   2. Regulation and Rapid Inactivation of the Light Induced cGMP Phosphodiesterase Activity in Vertebrate Retinal Rods

      • M. Chabre, P. Deterre, P. Catty, T. M. Vuong

      Pages 215-228

7. Āuxin-coupled systems

   1. Front Matter

      Pages 229-229

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Activation by and desensitization to signals originating from the environment is common in all organisms, ranging from prokaryotes to higher eukaryotes. Recently, a number of novel mechanisms involved in activation and desensitization have been elucidated. The similarities of the molecular mechanisms of activation and desensitization in the various systems are striking. In the first book (1987) on this topic, the functional and structural similarities of the various mechanisms to attenuate the effect of an outward signal were emphasized. Justification to have a second book three years later is the explosive growth of information in the field. More components involved in signal transfer have been discovered and also that several more G-proteins appear to play a role during this process. The interest in signal attenuation concurs with these developments. The emphasis in this book is on the common signal transfer elements responsible for activation and desensitization in animals, plants and microorganisms.

• Activation
• Aktivierung, molekulare
• Desensibilisierung
• G-Proteine
• Pharmakologie
• Signalweiterleitung
• molecular mechanisms
• proteins

• Zoölogisch Laboratorium, Leiden, The Netherlands

  T. M. Konijn

• Institute of Biochemistry, The University of Glasgow, Glasgow, Scotland

  M. D. Houslay

• Biochemisch Laboratorium, Groningen, The Netherlands

  P. J. M. Haastert

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