Preclinical Hyperthermia

1. Front Matter

   Pages I-XI

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2. Modification of Heat Action and Thermal Enhancement of Radio- and Chemotherapy

   1. Hyperthermic Toxicity and the Modulation of Heat Damage to Cell Protein Synthesis in HeLa Cells

      • R. H. Burdon

      Pages 1-8

   2. Membranes as Targets for Hyperthermic Cell Killing

      • A. W. T. Konings

      Pages 9-21

   3. Sulfhydryl Compounds as Thermosensitizers

      • R. D. Issels

      Pages 22-27

   4. Therapeutic Benefit from Combined Heat and Radiation

      • S. A. Hill, J. Denekamp

      Pages 28-34

   5. Correlation Between Polymerase ß Activity and Thermal Radiosensitization in Chinese Hamster Ovary Cells

      • E. Dikomey, H. Jung

      Pages 35-41

3. Effect of Heat and Combined Treatments on Normal Tissues

   1. The Problem of Defining Thermal Dose

      • M. P. Law, S. B. Field

      Pages 42-49

   2. Effect of Hyperthermia on Human Natural Killer Cells

      • M. Onsrud

      Pages 50-56

   3. Effect of Hyperthermia at 40.5° C and Cytostatic Drugs on Human Bone Marrow Progenitor Cells

      • H. A. Neumann, R. Engelhardt

      Pages 57-63

   4. Combined Heat and X-Ray Toxicities in Intestine and Skin

      • S. P. Hume

      Pages 64-70

   5. Toxic Effects of Irradiation or Doxorubicin in Combination with Moderate Whole-Body Hyperthermia on Bone Marrow in Rats

      • W. Hinkelbein, M. Birmelin, D. Menger, R. Engelhardt

      Pages 71-82

   6. Cardiotoxicity of Moderate Whole-Body Hyperthermia, Doxorubicin, and Combined Treatment in Rats

      • M. Birmelin, W. Hinkelbein, W. Oehlert, M. Wannenmacher

      Pages 83-88

4. Preclinical Hpyerthermia in Animal Tumors and Malignant Cell Lines

   1. Effects of Hyperthermic Treatments on Malignant Cells and Animal Tumors: Introductory Remarks

      • C. Streffer

      Pages 89-95

   2. Hyperthermia and Microcirculatory Effects of Heat in Animal Tumors

      • B. Endrich

      Pages 96-108

   3. Importance of the Glutathione Level and the Activity of the Pentose Phosphate Pathway in Cellular Heat Sensitivity

      • A. W. T. Konings

      Pages 109-125

   4. Potentiation of Hyperthermia by Lanthanum

      • L. Anghileri

      Pages 126-135

   5. Interactions of Hyperthermia with Hypoxic Cell Sensitisers

      • N. M. Bleehen, M. I. Walton, P. Workman

      Pages 136-148

   6. Thermal Enhancement of the Cell Killing Effect of X-Irradiation in Mammalian Cells in Vitro and in a Transplantable Mouse Tumor: Influence of pH, Thermotolerance, Hypoxia, or Misonidazole

      • J. Haveman, J. Wondergem

      Pages 149-160

   7. Thermal Enhancement of Drug Cytotoxicity in Vivo and in Vitro

      • D. J. Honess, N. M. Bleehen

      Pages 161-169

5. Effect of Heat and Combined Treatments on Human Tumors

   1. Preclinical Hyperthermia in Human Tumors: Introductory Remarks

      • R. Engelhardt

      Pages 170-172

Physicians and biologists here present their experimental work in the field of hyperthermia, paying particular regard to its relevance in clinical situations. Principles of heat action and combined treatment modalities are explicated. The main topics discussed are the effects of such treatment on normal tissues, animal tumors, malignant cell lines and human tumors.

• cancer
• cell
• chemotherapy
• hyperthermia
• melanoma
• ovarian cancer
• thermotherapy
• tumor

• Abteilung Strahlentherapie (Med. Klinik) Radiologische Klinik, Albert-Ludwigs-Universität, Freiburg, Germany

  Wolfgang Hinkelbein, Gregor Bruggmoser, Rupert Engelhardt, Michael Wannenmacher

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