ADP-Ribosylation of Proteins

1. Front Matter

   Pages I-XVI

   PDF

2. Poly-ADP-Ribosylation Reactions

   1. Front Matter

      Pages 1-1

      PDF

   2. Poly(ADP-Ribose): Structure, Properties and Quantification

      • Felix R. Althaus, Christoph Richter

      Pages 3-11

   3. Poly(ADP-Ribose) Biosynthesis

      • Felix R. Althaus, Christoph Richter

      Pages 12-37

   4. Poly(ADP-Ribose) Catabolism

      • Felix R. Althaus, Christoph Richter

      Pages 38-44

   5. Nuclear Acceptor Proteins for Poly(ADP-Ribose) and the Functional Consequences of Poly-ADP-Ribosylation on the Acceptor Species

      • Felix R. Althaus, Christoph Richter

      Pages 45-58

   6. Poly-ADP-Ribosylation and Chromatin Organization

      • Felix R. Althaus, Christoph Richter

      Pages 59-65

   7. Poly-ADP-Ribosylation in the Recovery of Mammalian Cells from DNA Damage

      • Felix R. Althaus, Christoph Richter

      Pages 66-92

   8. Poly(ADP-Ribose), DNA Synthesis, and Cell Cycle Progression

      • Felix R. Althaus, Christoph Richter

      Pages 93-100

   9. Poly(ADP-Ribose), Cellular Differentiation, and Gene Expression

      • Felix R. Althaus, Christoph Richter

      Pages 101-113

   10. Poly(ADP-Ribose) in Inherited Human Diseases and Experimental Disease Models

       • Felix R. Althaus, Christoph Richter

       Pages 114-125

3. Mono-ADP-Ribosylation Reactions

   1. Front Matter

      Pages 127-130

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   2. Signal Transduction

      • Felix R. Althaus, Christoph Richter

      Pages 131-139

   3. Cholera Toxin

      • Felix R. Althaus, Christoph Richter

      Pages 140-154

   4. Pertussis Toxin

      • Felix R. Althaus, Christoph Richter

      Pages 155-182

   5. Diphtheria Toxin

      • Felix R. Althaus, Christoph Richter

      Pages 183-194

   6. Cellular Transferases

      • Felix R. Althaus, Christoph Richter

      Pages 195-208

   7. Mitochondria

      • Felix R. Althaus, Christoph Richter

      Pages 209-215

   8. The Bond

      • Felix R. Althaus, Christoph Richter

      Pages 216-230

4. Back Matter

   Pages 231-237

   PDF

In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions. The development of this field over the past 2 decades reflects very much a modern trend of biological research. As more detailed knowledge accumulates, enigmatic phenomena turn into concepts which create their own enigmata. This process tends to favor the development of multiple, seemingly disconnected, research lines until simplicity emerges from chaos and unifying concepts substitute for controversy. It appears that the field of ADP-ribosylation reactions has not yet attained this latter stage. For example, with the identification of two different classes of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla­ tion and poly-ADP-ribosylation reactions, the field split very early into two separate branches of research. With the present volume, we have divided the task of reviewing these two classes of ADP­ ribosylation accordingly, although their coexistence in eukaryotes may involve a closer functional linkage than hitherto recognized.

• DNA
• biosynthesis
• cellular differentiation
• enzyme
• enzymes
• enzymology
• gene
• gene expression
• genes
• mitochondria
• protein
• proteins
• signal transduction
• synthesis
• translation

• Institut für Pharmakologie und Biochemie, Universität Zürich, Zürich, Germany

  Felix R. Althaus

• Laboratorium für Biochemie, ETH-Zentrum, Zürich, Germany

  Christoph Richter

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