Fibrin Sealant in Operative Medicine

1. Front Matter

   Pages I-XVI

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2. Principles of Fibrin Sealing

   1. Front Matter

      Pages 1-1

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   2. The Importance of Fibrin in Wound Repair

      • G. Schlag, H. Redl, M. Turnher, H. P. Dinges

      Pages 3-12

   3. Fibrin Sealant and Its Modes of Application

      • H. Redl, G. Schlag

      Pages 13-26

   4. Properties of Different Tissue Sealants with Special Emphasis on Fibrinogen-Based Preparations

      • H. Redl, G. Schlag

      Pages 27-38

   5. Lysis and Absorption of Fibrin Sealant (Tissucol/Tisseel)

      • H. Pflüger

      Pages 39-50

   6. Preliminary Results of a Randomized Controlled Study on the Risk of Hepatitis Transmission of a Two-Component Fibrin Sealant (Tissucol/Tisseel)

      • G. Eder, M. Neumann, R. Cerwenka, K. Baumgarten

      Pages 51-59

3. Plastic Surgery

   1. Front Matter

      Pages 61-61

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   2. The Use of Fibrin Sealant in Patients with Rhinophyma

      • O. Staindl

      Pages 63-70

   3. Fibrin Sealing in Plastic Surgery

      • A. Azzolini, A. Bocchi

      Pages 71-78

   4. Tissue-Adhesion Techniques in the Treatment of Extensive Postoperative Cavities and Fistulae

      • H. G. Bruck, E. Würinger

      Pages 79-84

   5. Further Clinical Applications of Human Fibrin Sealant in Plastic Surgery

      • N. Scuderi, G. Sposato, G. Di Caprio

      Pages 85-89

   6. Fibrin Sealant (Tissucol/Tisseel) and Its Application in Plastic and Reconstructive Surgery

      • J. Holle

      Pages 90-92

   7. Specific Indications for Fibrin Glue in Plastic and Craniomaxillofacial Surgery

      • M. Stricker, Ph. Maxant, A. Czorny

      Pages 93-97

   8. Fibrin Sealant in Burn Injuries — Experimental Study

      • G. Blümel, R. Ascherl, S. Haas, K. Geißdörfer, A. Stemberger, G. Schäfer et al.

      Pages 98-103

   9. Skin Grafting with Fibrin Sealant in Burns

      • R. Hettich

      Pages 104-109

   10. Fibrin Sealing in the Treatment of Burn Wounds

       • A. Grabosch

       Pages 110-115

   11. Fibrin Sealing in Dupuytren’s Contracture

       • E. Eide

       Pages 116-122

   12. Fibrinogen Glue (Tissucol/Tisseel) Skin Transplants in Leg Ulcers

       • J. Holm

       Pages 123-126

   13. New Aspects of Haemangioma Treatment

       • A. Krüger

       Pages 127-132

Fibrin plays a prominent role in wound healing. It has a hemostatic effect, induces cellular response to wound damage, and, by forming strands to build a matrix, assists in neovascularization and fibroblast proliferation. The concept of using clotting substances from human blood for wound manage­ ment and to achieve hemostasis in bleeding parenchymatous organs can be traced to 1909, when Bergel [1] reported on the hemostatic effect offibrin powder. In 1915, Grey [3] employed fibrin to control bleeding in neurosurgical operations of the brain. A year later, Harvey [4] used fibrin patches to stop bleeding from parenchy­ matous organs in general surgery. It took more than two decades for this ingenious idea to be rediscovered. In 1940, Young and Medawar [8] reported on experimental nerve anastomosis by sealing. Similarly, Tarlov and Benjamin [7] reunited nerves with plasma clots in 1943. Tarlov improved the results obtained with clot anastomosing of nerves by avoiding tension at the nerve stumps. In 1944, Cronkite et al. [2] reported on an initial series of eight cases in which fibrinogen and thrombin had been used successfully for anchoring skin grafts.

• blood
• brain
• general surgery
• medicine
• plasma
• plastic surgery
• proliferation
• reconstructive surgery
• skin
• surgery

• Ludwig-Boltzmann-Institut für experimentelle Traumatologie, Vienna, Austria

  Günther Schlag, Heinz Redl

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