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Perioperative Chemotherapy

Rationale, Risk and Results

  • Book
  • © 1985

Overview

Editors:
  1. Urs Metzger

    1. Chirurgische Onkologie Departement Chirurgie, Universitätsklinik, Zürich, Switzerland

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  2. Felix Largiadèr

    1. Departement Chirurgie, Universitätsklinik, Zürich, Switzerland

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  3. Hans-Jörg Senn

    1. Medizinische Klinik C, Kantonsspital St. Gallen, St. Gallen, Switzerland

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 98)

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Table of contents (21 chapters)

  1. Front Matter

    Pages I-XII
    Download chapter PDF

  3. Breast Cancer

    1. Preoperative Chemotherapy: Advantages and Clinical Application in Stage III Breast Cancer

      • A. N. Papaioannou
      Pages 65-90

    2. Short Perioperative Versus Long-Term Adjuvant Chemotherapy

      • R. Nissen-Meyer, H. Host, K. Kjellgren, B. Mansson, T. Norin
      Pages 91-98

    3. Preoperative Adjuvant Chemotherapy (Neoadjuvant) for Carcinoma of the Breast: Rationale and Safety Report

      • J. Ragaz, R. Baird, R. Rebbeck, A. Goldie, A. Coldman, J. Spinelli
      Pages 99-105

    4. Perioperative and Conventionally Timed Chemotherapy in Operable Breast Cancer

      • A. Goldhirsch
      Pages 106-113

    5. Panel Discussion: Perioperative Chemotherapy for Breast Cancer

      • Urs Metzger, Felix Largiadèr, Hans-Jörg Senn
      Pages 114-115

  4. Various Tumors

    1. Perioperative and Adjuvant Chemotherapy in Gastric Cancer

      • P. Schlag, W. Schreml
      Pages 116-121

    2. The Risks of Perioperative Chemotherapy in Large-Bowel Cancer Surgery

      • U. Metzger
      Pages 122-125

    3. The Need for Pilot Studies and Surgery-Only Controls in Adjuvant Therapy Trials for Large-Bowel Cancer

      • W. Weber-Stadelmann
      Pages 126-129

    4. Clinical Experience with Preoperative Chemotherapy for Osteosarcoma

      • H. P. Honegger, M. Cserhati, A. R. von Hochstetter, V. Hofmann, P. Groscurth
      Pages 130-134

    5. Effect of Intensive Adjuvant Chemotherapy on Wound Healing in 69 Patients with Osteogenic Sarcomas of the Lower Extremities

      • O. Bertermann, R. C. Marcove, G. Rosen
      Pages 135-141

    6. Combined-Modality Treatment with Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

      • R. Abele, W. Lehmann, G. Pipard, P. Alberto
      Pages 142-147
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Keywords

About this book

One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas­ tases from it might be enhanced by suppression of immune and reticu­ loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro­ cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.

Editors and Affiliations

  • Chirurgische Onkologie Departement Chirurgie, Universitätsklinik, Zürich, Switzerland

    Urs Metzger

  • Departement Chirurgie, Universitätsklinik, Zürich, Switzerland

    Felix Largiadèr

  • Medizinische Klinik C, Kantonsspital St. Gallen, St. Gallen, Switzerland

    Hans-Jörg Senn

Bibliographic Information

  • Book Title: Perioperative Chemotherapy

  • Book Subtitle: Rationale, Risk and Results

  • Editors: Urs Metzger, Felix Largiadèr, Hans-Jörg Senn

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-82432-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1985

  • Softcover ISBN: 978-3-642-82434-0Published: 16 December 2011

  • eBook ISBN: 978-3-642-82432-6Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XII, 160

  • Number of Illustrations: 4 b/w illustrations

  • Topics: General Surgery, Oncology

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