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Vascular Perfusion in Cancer Therapy

  • Book
  • © 1983

Overview

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 86)

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Table of contents (47 chapters)

  1. Selective Embolization and Organ Perfusion with Cytostatics

  2. Isolated Liver Perfusion

Keywords

About this book

Substantial relief of discomfort may be anticipated by most patients suffering from pelvic and lower-extremity pain who are treated by arterial infusion of nitrogen mustard. Seventy-three patients with intractable pain secondary to malignancy arising in the pelvis received 83 percutaneous pelvic arterial infusions of this drug. Sixty infusions (72%) resulted in marked relief from pain for periods averaging 6-8 weeks. Advantages of the procedure are low toxicity, relative simplicity and availability of technique, and an acceptable rate of complications with minimal morbidity. Patients experiencing satisfactory results may expect significant relief from a second infusion for recurrent pain. The most rewarding result is the freedom from the cyclic return of pain characterized by oral and intramuscular analgesic therapy. Little or no relief can be expected in patients with pain caused by compression fractures of the vertebrae, or where the tumor burden is so great that adequate perfusion of the involved nerves is not possible. One should consider this procedure for controlling pain before resorting to the more dangerous and potentially disabling techniques of spinal cordotomy or intrathecal alcohol injection. References Bateman JR, Hazen JG, Stolinsky DC, Steinfeld JL (1966) Advanced carcinoma of the cervix treated by intra-arterial methotrexate. Am J Obstet Gynecol 96: 181-187 Calabresi P, Parks RW Jr (1970) Alkylating agents, antimetabolites, hormones. and other antiproliferative agents. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 4th edn.

Editors and Affiliations

  • Allgemeinchirurgische Klinik des Zentrums für Chirurgie, Justus-Liebig-Universität, Giessen, Germany

    Konrad Schwemmle, Karl Aigner

Bibliographic Information

  • Book Title: Vascular Perfusion in Cancer Therapy

  • Editors: Konrad Schwemmle, Karl Aigner

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-82025-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1983

  • Softcover ISBN: 978-3-642-82027-4Published: 06 January 2012

  • eBook ISBN: 978-3-642-82025-0Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XII, 298

  • Topics: Oncology, Biochemistry, general

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