Teratogenesis and Reproductive Toxicology

1. Front Matter

   Pages I-XVI

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2. Epidemiology and Bioavailability

   1. Front Matter

      Pages 1-1

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   2. Assessment of Potential Hazards to the Unborn in the Workplace

      • B. A. Schwetz, K. S. Rao, L. W. Rampy

      Pages 3-6

   3. Pharmacokinetic Modeling and the Teratologist

      • J. F. Young

      Pages 7-29

   4. Placental Drug Metabolism

      • S. T. Chao, M. R. Juchau

      Pages 31-48

   5. Genetic Differences in Drug Metabolism: Proposed Relationship to Human Birth Defects

      • D. W. Nebert

      Pages 49-62

3. Mechanisms of Teratogenesis

   1. Front Matter

      Pages 63-63

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   2. Viruses as Teratogens

      • J. L. Sever

      Pages 65-73

   3. Hormonal Involvement in Palatal Differentiation

      • R. M. Greene

      Pages 75-92

   4. Membrane Lipids and Differentiation

      • K. P. Chepenik, S. A. Waldman

      Pages 93-111

   5. Hormone Receptors and Malformations

      • D. S. Salomon

      Pages 113-134

   6. Mutagens as Teratogens: A Correlative Approach

      • C. A. Schreiner, H. E. Holden Jr.

      Pages 135-168

4. Adverse Effects on Function

   1. Front Matter

      Pages 169-169

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   2. Behavioral Testing Procedures: A Review

      • R. P. Jensh

      Pages 171-206

   3. Behavioral Teratology: A New Frontier in Neurobehavioral Research

      • D. E. Hutchings

      Pages 207-235

   4. Abnormal Lung Function Induced by Prenatal Insult

      • L. M. Newman, E. M. Johnson

      Pages 237-261

   5. Postnatal Alterations of Gastrointestinal Physiology, Hematology, Clinical Chemistry, and Other Non-CNS Parameters

      • M. S. Christian

      Pages 263-286

5. In Vitro Screens of Teratogenic Potential

   1. Front Matter

      Pages 287-287

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   2. Detection of Teratogens Using Cells in Culture

      • J. H. Greenberg

      Pages 289-299

   3. Embryonic Organs in Culture

      • D. M. Kochhar

      Pages 301-314

The resolution of links between exposure to components of our complex environmental and causation of reproductive effects in the population constitutes an important problem in the field of toxicology. The focus of this volume is developmental toxicology, which represents one aspect of reproductive toxicology dealing with the study of adverse effects on the developing conceptus. Developmental toxicology, which includes teratogenesis as one of its manifesta­ tions, provides a fertile field for research in several basic and clinical disciplines; this field also receives input from several disoiplines such as developmental and molecu­ lar biology, pathology, pharmacology and toxicology, pediatrics and neonatology, and epidemiology. More recently we h~ve seen an emergence of interest in other fields such as perinatal physiology and postnatal behavior which have now become incorporated into the mainstream of research in this discipline. The present volume is an effort to provide a sampling of concepts currently under active investigation in several of the above fields. The authors have endeavored to provide up-to-date in­ formation on the following topics: detection and analysis of potential hazards to the conceptus in the workplace, pharmacokinetic aspects of the maternal/placental! fetal complex and its relationship to human birth defects, and probable mechanisms of teratogenesis as uncovered in certain well-defined situations. Also included are summaries of newer investigations on the emerging field of postnatal functional evaluations, i. e. , adverse effects on adult activities resultant from in utero exposure to toxic substances.

• Pharmakologie
• biology
• environment
• pharmacology
• physiology
• research
• toxicology

• Jefferson Medical College, Philadelphia, USA

  E. Marshall Johnson

• Department of Anatomy, Daniel Baugh Institute, Thomas Jefferson University, Philadelphia, USA

  Devendra M. Kochhar

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