Biological Chemistry of Organelle Formation

1. Front Matter

   Pages I-IX

   PDF

2. Structure and Nucleotide Sequence of the Cytochrome B Gene in Yeast Mitochondrial DNA

   • A. Tzagoloff, F. G. Nobrega

   Pages 1-10

3. Sequence of Mammalian Mitochondrial DNA

   • B. G. Barrell, S. Anderson, A. T. Bankier, M. H. L. De Bruijn, E. Chen, A. R. Coulson et al.

   Pages 11-25

4. The Optional Introns in Yeast Mitochondrial DNA

   • P. Borst

   Pages 27-41

5. Synthesis and Assembly of Mitochondrial Membrane Proteins

   • S. Werner

   Pages 43-58

6. Primary Structure of Mitochondrial Membrane Proteins: Evolutionary, Genetic and Functional Aspects

   • G. Buse

   Pages 59-70

7. Early Biological Evolution Derived from Chemical Structures

   • M. O. Dayhoff, R. M. Schwartz

   Pages 71-86

8. Studies of the Maize Chloroplast Chromosome

   • L. Bogorad, S. O. Jolly, G. Link, L. McIntosh, C. Poulsen, Z. Schwarz et al.

   Pages 87-96

9. The Plastid Chromosomes of Several Dicotyledons

   • R. G. Herrmann, P. Seyer, R. Schedel, K. Gordon, C. Bisanz, P. Winter et al.

   Pages 97-112

10. Synthesis, Transport, and Assembly of Chloroplast Proteins

    • N.-H. Chua, A. R. Grossman, S. G. Bartlett, G. W. Schmidt

    Pages 113-117

11. Role of the Golgi Complex in Intracellular Transport

    • V. Herzog

    Pages 119-145

12. The Role of Free and Membrane-Bound Polysomes in Organelle Biogenesis

    • G. Kreibich, S. Bar-Nun, M. Czako-Graham, W. Mok, E. Nack, Y. Okada et al.

    Pages 147-163

13. Transport of Membranes and Vesicle Contents During Exocytosis

    • M. Gratzl

    Pages 165-174

14. Assembly and Turnover of the Subsynaptic Membrane

    • H. Betz, H. Rehm

    Pages 175-186

15. Biogenesis of Peroxisomes and the Peroxisome Reticulum Hypothesis

    • P. B. Lazarow, H. Shio, M. Robbi

    Pages 187-206

16. Origin and Dynamics of Lysosomes

    • K. v. Figura, U. Klein, A. Hasilik

    Pages 207-219

17. The Semliki Forest Virus Envelope: A Probe for Studies of Plasma Membrane Structure and Assembly

    • H. Garoff, K. Simons

    Pages 221-234

18. Assembly of Membrane Proteins in Escherichia coli. A Genetic Approach

    • M. Schwartz

    Pages 235-244

19. Studies of the Path of Assembly of Bacteriophage M13 Coat Protein Into the Escherichia coli Cytoplasmic Membrane

    • P. Hearne, M. Nokelainen, A. Ponticelli, Y. Hirota, K. Ito, W. Wickner

    Pages 245-249

20. Back Matter

    Pages 251-257

    PDF

Eukaryotic cells contain a plurality of organelles distinguished by their specific membranes and contents. Their biogenesis occurs by growth and division of preexisting structures rather than de novo. Mitochondria and chloroplasts, which appear to be descended from prokaryotic ancestors, have retained some DNA and the biosynthetic capability for its expression. They synthesize, however, only a few of their proteins themselves. Most of their proteins are synthesized on free ribosomes in the cytoplasm and are only assembled in the correct membrane after synthesis is complete. The biogenesis of peroxisomes and glyoxysomes also appears to occur by an incorporation of proteins synthesized first in the cytoplasm. Other organelles, the Golgi complex, lysosomes, secretory vesicles, and the plasma membrane, are formed in a different manner. Their proteins are assembled in the membrane of the endoplasmic reticulum during trans­ lation by bound ribosomes and they must then be transported to the correct membrane. The 1980 Mosbach Colloquium was one of the first attempts to discuss the biogenesis of the various organelles in biochemical terms. This was appropriate since the crucial problems now center on the search for signals and receptors that dictate the site of assembly, the route taken, and the final location of a particular organelle protein. The assembly of prokaryotic membranes and the membrane of an animal virus were also discussed, since these simpler systems might shed light on the biogenesis of organelles in eukaryotes.

• Chemistry
• Chloroplast
• DNA
• Organell
• Peroxisom
• proteins

• Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München, München 2, Germany

  Th. Bücher

• Gesellschaft für Biotechnologische Forschung mbH, Braunschweig-Stöckheim, Germany

  W. Sebald

• Europäisches Laboratorium für Molekularbiologie, Heidelberg, Germany

  H. Weiss

Policies and ethics