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Advanced Methods in Protein Sequence Determination

  • Book
  • © 1977

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Authors:
  1. Saul B. Needleman

    1. Scientific Affairs, Abbott Laboratories, North Chicago, USA

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Table of contents (8 chapters)

  1. Front Matter

    Pages I-XII
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  2. Step-wise Degradation of Peptides Attached to Solid Supports

    • G. A. Mross, R. F. Doolittle
    Pages 1-20

  3. Coupling Methods and Strategies in Solid-Phase Sequencing

    • R. A. Laursen, M. J. Horn
    Pages 21-37

  4. Sequencing Peptides and Proteins Lacking Free ฮฑ-Amino Groups

    • R. F. Doolittle
    Pages 38-54

  5. Use of Antibody in the Study of Protein Structure

    • M. Reichlin
    Pages 55-67

  6. Polarization of Light and Protein Structure

    • S. B. Needleman
    Pages 68-74

  7. The X-ray Crystallography Technique in Protein Sequencing

    • K. K. Kannan
    Pages 75-122

  8. Amino Acid Sequence Determination by Mass Spectrometry

    • H. Falter
    Pages 123-148

  9. Peptide Sequence Analysis by Nuclear Magnetic Resonance Spectroscopy

    • E. Nieboer, H. Falter
    Pages 149-171

  10. Back Matter

    Pages 172-191
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About this book

Confusion now hath made his masterpiece Macbeth II iii 72 Whence and what are those execrable shape? Paradise Lost Ib 1 681 Confusion worse confounded Paradise Lost Ib 1 995 When the manuscript for the first part of this book was proposed, it was anticipated that the discussion of the entire field of protein seยญ quencing could be covered in a single volume - from purification and characterization of the protein through fragmentation by chemical or enzymic means and, finally, to reassembly of the identified individual peptides into the reconstructed total sequence. It soon became evident that this would not be possible. While the intent was to restrict the expose of procedures only to that information concerned with "hands on" wet chemistry, it became apparent that a thorough presentation would require, in addition, a discussion of certain instrumental and more theoretical approaches not included in the first volume. Furthermore, the entire understanding of the field of protein sequencing has advanced appreciably since the inception of this book. The purpose of the first volume was to provide practical information in sufficient detail to permit the researcher to undertake the actual sequencing procedures in his own laboratory.

Authors and Affiliations

  • Scientific Affairs, Abbott Laboratories, North Chicago, USA

    Saul B. Needleman

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