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The Immune System

27. Colloquium, 29. April bis 1. Mai 1976

  • Conference proceedings
  • © 1976

Overview

Editors:
  1. Fritz Melchers

    1. Basel Institute of Immunology, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  2. Klaus Rajewsky

    1. Institut für Genetik, Köln, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden (MOSBACH, volume 27)

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Table of contents (23 papers)

  1. Front Matter

    Pages I-XIV
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  2. Antibody Structure

    1. Front Matter

      Pages 1-1
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    2. The Structural Basis of Antibody Specificity

      • E. A. Kabat
      Pages 3-18

    3. Structure and Specificity of Immunoglobulins

      • R. J. Poljak, L. M. Amzel, B. L. Chen, Y. Y. Chiu, R. P. Phizackerley, F. Saul et al.
      Pages 19-25

    4. X-Ray Diffraction Analysis of Immunoglobulin Structure

      • R. Huber, J. Deisenhofer, P. M. Colman, M. Matsushima, W. Palm
      Pages 26-40

    5. Recognition and Allostery in the Mechanism of Antibody Action

      • I. Pecht
      Pages 41-54

  3. Antibody Structural Genes

    1. Front Matter

      Pages 55-55
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    2. Structure and Genetics of Antibodies

      • R. R. Porter
      Pages 57-64

    3. Genetic Control of T and B Cell Receptor Specificity in the Mouse

      • K. Eichmann, C. Berek, G. Hämmerling, S. Black, K. Rajewsky
      Pages 65-74

    4. Immunoglobulin mRNA and Immunoglobulin Genes

      • C. Milstein, G. G. Brownlee, C. C. Cheng, P. H. Hamlyn, N. J. Proudfoot, T. H. Rabbitts
      Pages 75-85

    5. Differentiation of Immunoglobulin Genes

      • S. Tonegawa, N. Hozumi
      Pages 86-97

  4. Immunocompetent Cells

    1. Front Matter

      Pages 99-99
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    2. Phylogenesis of the Vertebrate Immune System

      • L. Du Pasquier
      Pages 101-115

    3. Characteristics of B Lymphocytes and Their Mechanism of Activation

      • G. Möller
      Pages 116-130

    4. T Lymphocytes

      • H. Wigzell
      Pages 131-140

    5. Tumors of Immunoglobulin-Producing Cells and Thymus-Derived Lymphocytes

      • M. Potter
      Pages 141-172

    6. Macrophages

      • H. Fischer
      Pages 173-177

  5. The Major Histocompatibility Complex and Cellular Recognition

    1. Front Matter

      Pages 179-179
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    2. The Major Histocompatibility Complex and Its Biological Function

      • E. D. Albert
      Pages 181-188

    3. Specificity of Immune Response Control by H-Linked Ir Genes

      • E. Rüde, E. Günther
      Pages 189-201
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Keywords

About this book

The cells of the immune system generate a large variety of binding sites which differ in their binding specificities and can therefore react specifically with a large variety of ligands. These binding sites are part of receptor molecules, enabling the system to react to the universe of antigens. The classical antigen receptor is the antibody molecule, and accord­ ingly the first session of this colloquium deals with a classical sub­ ject, namely antibody structure. Dramatic recent advances in this field make it possible to interrelate primary and three-dimensional struc­ ture both to each other and to function, i.e. the binding of antigen and possible reactions occurring in the antibody molecule upon antigen binding. The latter point is of particular interest since it may be relevant not only for effector functions of antibodies such as the binding of complement, but also for the triggering of a lymphocyte through its antibody receptor for antigen.

Editors and Affiliations

  • Basel Institute of Immunology, Basel, Switzerland

    Fritz Melchers

  • Institut für Genetik, Köln, Germany

    Klaus Rajewsky

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