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Selective Heat Sensitivity of Cancer Cells

  • Book
  • © 1977

Overview

Editors:
  1. Alessandro Rossi-Fanelli

    1. Institute of Biological Chemistry, University of Rome, Rome, Italy
      Center of Molecular Biology, C.N.R., Rome, Italy

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  2. Renato Cavaliere

    1. Regina Elena Institute for Cancer Research, Rome, Italy

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  3. Bruno Mondovì

    1. Institute of Applied Biochemistry, University of Rome, Rome, Italy

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  4. Guido Moricca

    1. Regina Elena Institute for Cancer Research, Rome, Italy

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 59)

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Table of contents (8 chapters)

  1. Front Matter

    Pages I-XII
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  2. Introduction

    • B. C. Giovanella, B. Mondovi
    Pages 1-6

  3. Biochemical Aspects of Heat Sensitivity of Tumour Cells

    • R. Strom, C. Crifo, A. Rossi-Fanelli, B. Mondovi
    Pages 7-35

  4. Actions of Hyperthermia on Tumor Cells Cultured in vitro

    • B. C. Giovanella
    Pages 36-42

  5. The Effects of Hyperthermia in Animal Tumour Systems

    • J. A. Dickson
    Pages 43-111

  6. Addendum

    • Alessandro Rossi-Fanelli, Renato Cavaliere, Bruno Mondovì, Guido Moricca
    Pages 111-111

  7. Hyperthermic Treatment of Tumours: Experimental and Clinical Applications

    • G. Moricca, R. Cavaliere, A. Caputo, A. Bigotti, F. Colistro
    Pages 112-152

  8. Whole-Body Hyperthermia. A Systemic Treatment for Disseminated Cancer

    • R. T. Pettigrew, C. M. Lugate
    Pages 153-170

  9. Hyperthermic Perfusion of Extremities for Melanoma and soft Tissue Sarcomas

    • J. S. Stehlin Jr., B. C. Giovanella, P. D. de Ipolyi, L. R. Muenz, R. F. Anderson, A. A. Gutierrez
    Pages 171-185

  10. Back Matter

    Pages 187-192
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Keywords

About this book

Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio­ chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.

Editors and Affiliations

  • Institute of Biological Chemistry, University of Rome, Rome, Italy

    Alessandro Rossi-Fanelli

  • Center of Molecular Biology, C.N.R., Rome, Italy

    Alessandro Rossi-Fanelli

  • Regina Elena Institute for Cancer Research, Rome, Italy

    Renato Cavaliere, Guido Moricca

  • Institute of Applied Biochemistry, University of Rome, Rome, Italy

    Bruno Mondovì

Bibliographic Information

  • Book Title: Selective Heat Sensitivity of Cancer Cells

  • Editors: Alessandro Rossi-Fanelli, Renato Cavaliere, Bruno Mondovì, Guido Moricca

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-81080-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin · Heidelberg 1977

  • Softcover ISBN: 978-3-642-81082-4Published: 21 December 2011

  • eBook ISBN: 978-3-642-81080-0Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XII, 192

  • Number of Illustrations: 26 b/w illustrations

  • Topics: Oncology, Cell Biology

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