Malignant Bone Tumors

1. Front Matter

   Pages I-VIII

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2. Introduction

   1. Bone Tumors — A Challenge for Cooperation

      • E. Grundmann

      Pages 1-2

3. Experimental Tumors

   1. Comparative Pathology of Bone Tumors in Animals, with Particular Emphasis on the Dog

      • S. W. Nielsen

      Pages 3-16

   2. Bone Tumors Induced by Inhalation of 238PuO2 in Dogs

      • J. F. Park, J. E. Lund, H. A. Ragan, P. L. Hackett, M. E. Frazier

      Pages 17-35

   3. Experimental Induction of Bone Tumors by Short-Lived Bone-Seeking Radionuclides

      • W. Gössner, O. Hug, A. Luz, W. A. Müller

      Pages 36-49

4. Pathogenesis

   1. Etiology of Childhood Bone Cancer: Epidemiologic Observations

      • R. W. Miller

      Pages 50-62

   2. The Endogenous Origin and Transmission of RNA Viral Genomes that Code for Cancer

      • R. J. Huebner

      Pages 63-91

   3. Pathogenesis of Radiation and Virus-Induced Bone Tumors

      • M. P. Finkel, C. A. Reilly Jr., B. O. Biskis

      Pages 92-103

5. Pathology

   1. The WHO Classification of Bone Tumors

      • H. A. Sissons

      Pages 104-108

   2. Primary Malignancy, Secondary Malignancy and Semimalignancy of Bone Tumors

      • E. Uehlinger

      Pages 109-119

   3. Common Errors Made by Pathologists in the Diagnosis of Bone Tumors

      • L. V. Ackerman

      Pages 120-138

   4. Aspiration (Puncture or Needle) Biopsy in Bone Lesions

      • F. Schajowicz, J. Hokama

      Pages 139-144

   5. Cytologic and Cytochemical Behavior of Primary Malignant Bone Tumors

      • M. Salzer-Kuntschik

      Pages 145-156

   6. Histochemical and Electron-Microscopic Aspects of Bone Tumor Diagnosis

      • W. Remagen, F. Gudat, P. Heitz

      Pages 157-165

6. Immunology

   1. Morphological, Biological, Immunological and Biochemical Studies on Bone Tumors of Animals and Man

      • L. Dmochowski

      Pages 166-184

   2. Immunologic Aspects of Human Sarcomas

      • D. J. Pritchard, J. C. Ivins, R. E. Ritts Jr.

      Pages 185-196

   3. The Immune-Status in Patients with Bone and Soft-Tissue Sarcomas

      • R. Kotz, W. Rella, M. Salzer

      Pages 197-205

   4. Laboratory Models of Minimal Residual Cancer; Development and Preliminary Immunotherapy Studies

      • Ch. M. Southam

      Pages 206-217

7. Therapy

   1. The Treatment of Malignant Bone Tumors by Conservative Surgery

      • R. C. Marcove

      Pages 218-220

   2. Management of Osteogenic Sarcoma at the Mayo Clinic

      • J. C. Ivins, D. J. Pritchard

      Pages 221-230

Bone Tumors - A Challenge for Cooperation E. GRUNDMANN Among the wide variety of human tumors, those of the skeletal system have an exceptional position in several respects. Above all, they are comparatively rare, and that is why reliable diagnostic criteria were compiled only recently, that is during the last three decades. It is only five years since the outlines of an international code of classi­ fication were traced. The code was applied and discussed critically and with varying results by several international working groups. Cer­ tain drawbacks are due to the broad and manifold spectrum of histolo­ gic manifestations in neoplastic bone. Even the best experts in dia­ gnostic histology would hardly be able to classify more than 85% of all bone tumors after the proposed code system. For quite a long time the osteoclastic giant cells, observed in almost any kind of bone tumor, have so much fascinated the histologist's eye that he was apt to pro­ claim the diagnosis "brown giant cell tumor" for almost any osteoclas­ tic tumor regardless of its benignity or malignancy. Nowadays the group of "giant cell tumors" though'restricted, still remains disputed in terms of malignancy and benignity. The problem will certainly not be settled in a definite way without extensive follow-up studies. In this context we may see actual progress in new regional. bone tumor registries being set up after the American example in many countries, among them the German Federal Republic.

• Bone
• cell
• diagnosis
• diseases
• histology
• neoplasm
• tumor

• Pathologisches Institut, Münster, Germany

  Ekkehard Grundmann

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