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Complications of Cancer Chemotherapy

Proceedings of the Plenary Sessions of E.O.R.T.C., Paris, June 1973

  • Conference proceedings
  • © 1974

Overview

Editors:
  1. Georges Mathé

    1. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, Villejuif, France

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  2. Robert K. Oldham

    1. Cellular and Tumor Immunology Section Department of Health, Education and Welfare, N.I.H., Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 49)

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Table of contents (20 papers)

  1. Front Matter

    Pages I-VI
    Download chapter PDF

  2. Introduction

    • G. Mathé, R. K. Oldham
    Pages 1-2

  3. Application of Large Animal Toxicology to the Qualitative and Quantitative Predication of Drug Toxicity in Man

    • S. K. Carter
    Pages 3-14

  4. Hematological Toxicity: Biological Basis

    • L. M. van Putten
    Pages 15-19

  5. Immunological Toxicity of Cancer Chemotherapy

    • G. W. Santos
    Pages 20-23

  6. Bacterial and Fungal Infections During Cancer Chemotherapy

    • V. Rodriguez, G. P. Bodey, E. J. Freireich
    Pages 24-28

  7. A Study of Viral Infections in Patients Treated with a Combination of 6 Mercaptopurine-Methotrexate: Preliminary Results

    • C. Jasmin, F. Bricout, J. M. Huraux, R. Weiner, R. K. Oldham, G. Mathé
    Pages 29-33

  8. Role of Gnotobiotic Care in Chemotherapy of Acute Leukemia

    • M. Dietrich
    Pages 34-39

  9. White Blood Cell Transfusions in Leukemic Patients with Severe Infections

    • A. Bussel, M. Benbunan, M. Weil, J. Reviron, C. Jacquillat, M. Boiron et al.
    Pages 40-47

  10. Efficacy of Platelet Transfusions from HL-A Compatible Unrelated Donors to Alloimmunized Patients

    • H.-P. Lohrmann, M. I. Bull, J. A. Decter, R. A. Yankee, R. G. Graw Jr.
    Pages 48-55

  11. Immune Responsiveness in Acute Lymphocytic Leukemia Patients under Chemotherapy and Immunotherapy: A Preliminary Report

    • J. Breard, R. S. Weiner, R. K. Oldham, G. Mathé
    Pages 56-60

  12. Transfer Factor Therapy in Immunodeficiencies

    • C. Griscelli, H. Betuel, C. Herzog, J. L. Touraine, J. P. Revillard
    Pages 61-73

  13. Reconstitution of Cellular Immunity in Hodgkin’s Disease with Transfer Factor

    • A. Khan, J. M. Hill, E. Loeb, A. MacLellan, N. O. Hill
    Pages 74-80

  14. Complications of Cancer Chemotherapy. The Special Case of Hormones

    • J. C. Heuson
    Pages 81-87

  15. Factors Modifying the Activity and Toxicity of Anticancer Agents

    • F. Spreafico, M. G. Donelli, A. Vecchi, A. Bossi, S. Garattini
    Pages 88-94

  16. Modification of Drug Metabolism Induced in the Host by the Presence of a Tumor

    • I. Bartošek, M. G. Donelli, A. Guaitani
    Pages 95-100

  17. Is Local Chemotherapy Less Toxic than Systemic?

    • P. J. Sindram
    Pages 101-102

  18. Pharmacokinetic Simulation: A Future Means for Better Control of Cancer Chemotherapy

    • Th. Lincoln, E. J. Freireich
    Pages 103-107

  19. Carcinogenesis by Cancer Chemotherapeutic Agents: Second Malignancies Complicating Hodgkin’s Disease in Remission

    • G. P. Canellos, V. T. de Vita, J. C. Arseneau, R. C. Johnson
    Pages 108-114

  20. Malignancies Possibly Secondary to Anticancer Therapy

    • D. Belpomme, P. Carde, R. K. Oldham, G. Mathé, C. Jacquillat, N. Chelloul et al.
    Pages 115-123
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Keywords

About this book

G. MATHE and R. K. OLDHAM'~ Institut de Cancerologie et d'Immunogem!tique, Hopital Paul Brousse, Villejuif Since the last war, cancer chemotherapy has been the object of very intensive and expensive research. Nevertheless, its development has been very slow, and its ultimate potential is today somewhat in doubt. In doubt because it does not cure any cancer patients except a) females carrying placental choriocarcinoma, a semi-allogenic tumor, in which case, cure may be in­ fluenced by immune rejection, and b) children suffering from Burkitt's tumor, where the probable reason for the cure is that all the neoplastic cells are in the cycle, which is a unique condition among all the human tumor varieties. Whether the long term survivors in acute leukemia, lymphomas, certain sarcomas and certain testicular tumors are "cures" will require longer follow-up. The idea that chemotherapy does not cure most cancer patients because all their neoplastic cells are not in cycle has led to the use of drug combinations. Whatever they are, "cocktail combinations" which are made up of drugs given according to any timing, or scientific combinations, based on pharmacodynamics, pharmaco­ kinetics or cell kinetics data, are more toxic than single drugs, and are all the more toxic as the number of drugs in the combination is increased.

Editors and Affiliations

  • Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, Villejuif, France

    Georges Mathé

  • Cellular and Tumor Immunology Section Department of Health, Education and Welfare, N.I.H., Bethesda, USA

    Robert K. Oldham

Bibliographic Information

  • Book Title: Complications of Cancer Chemotherapy

  • Book Subtitle: Proceedings of the Plenary Sessions of E.O.R.T.C., Paris, June 1973

  • Editors: Georges Mathé, Robert K. Oldham

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-80848-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin · Heidelberg 1974

  • Softcover ISBN: 978-3-642-80850-0Published: 09 January 2012

  • eBook ISBN: 978-3-642-80848-7Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: VI, 142

  • Number of Illustrations: 4 b/w illustrations

  • Topics: Rehabilitation, Cancer Research

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