Metabolic Interconversion of Enzymes 1973

1. Front Matter

   Pages I-XVI

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2. Introductory Remarks

   1. Introductory Remarks

      • Carl F. Cori

      Pages 1-5

3. Phosphorylation-Dephosphorylation

   1. Glycogen Phosphorylase

      1. Studies on the Molecular Aspects of Phosphorylase <i>b</i> → <i>a</i> Conversion

         • David J. Brooks, Stephen J. W. Busby, Raymond A. Dwek, John R. Griffiths, George K. Radda

         Pages 7-19

      2. Role of 5′AMP and of Its Analogs in the Activation of Muscle Glycogen Phosphorylase <i>b</i>

         • H. Buc, M. H. Buc, F. Garcia Blanco, M. Morange, H. Winkler

         Pages 21-31

      3. The Role of the <i>α</i> and <i>β</i> Subunits in the Regulation of Phosphorylase Kinase Activity

         • Philip Cohen, John F. Antoniw, Michael Davison, Carol Taylor

         Pages 33-42

      4. Purification and Properties of Rabbit Muscle Phosphorylase Phosphatase

         • D. Gratecos, T. Detwiler, E. H. Fischer

         Pages 43-52

      5. The Use of Alternative Substrates in the Study of Phosphorylase Phosphatase and Phosphorylase Kinase

         • Donald J. Graves, Todd M. Martensen, Jan-I Tu, George M. Tessmer

         Pages 53-61

   2. Glycogen Synthetase

      1. Studies on Glycogen Synthase and Its Control by Hormones

         • J. Larner, C. H. Smith, A. M. Rosenkrans, T. B. Miller Jr., L. C. Huang, C. Villar-Palasi et al.

         Pages 63-73

      2. Liver Glycogen Synthetase

         • Harold L. Segal, David C. Lin

         Pages 75-87

      3. The Control of Glycogen Metabolism in the Liver

         • H. G. Hers, W. Stalmans, H. De Wulf, M. Laloux, L. Hue

         Pages 89-98

   3. Pyruvate Dehydrogenase Complex

      1. Structure, Function and Regulation of the Mammalian Pyruvate Dehydrogenase Complex

         • Lester J. Reed, Flora H. Pettit, Thomas E. Roche, Peter J. Butterworth, Cecilio R. Barrera, C. Stanley Tsai

         Pages 99-106

      2. Regulation of Mammalian Pyruvate Dehydrogenases

         • Ronald H. Cooper, Richard M. Denton, Helen T. Pask, Philip J. Randle, David L. Severson, Sue Whitehouse

         Pages 107-116

      3. On the Mechanism of Insulin Action on Pyruvate Dehydrogenase Interconversion in Adipose Tissue

         • Otto H. Wieland, Ludwig Weiss, Georg Löffler, Ingrid Brunner, Sabine Bard

         Pages 117-129

   4. Cyclic AMP Dependent and Independent Protein Kinases

      1. Protein Kinase Activity in <i>Escherichia coli</i>

         • Donald M. Powers, Ann Ginsburg

         Pages 131-142

      2. Molecular Characterization of Cyclic AMP-Dependent Protein Kinases Derived from Bovine Heart and Human Erythrocytes

         • Ora M. Rosen, Jack Erlichman, Charles S. Rubin

         Pages 143-154

   5. Phosphorylation of Non-Enzymatic Proteins

      1. Ribosomal Proteins from Rabbit Reticulocytes: Numbers, Molecular Weights, Relative Amounts and Phosphorylation by Protein Kinases

         • Robert R. Traut, Guy A. Howard, Jolinda A. Traugh

         Pages 155-164

      2. Phosphorylation of Ribosomal Proteins in Higher Organisms

         • Alphonse Krystosek, Lawrence F. Bitte, David Kabat

         Pages 165-173

      3. Phosphorylation and Dephosphorylation of Skeletal Muscle Troponin

         • P. J. England, J. T. Stull, T. S. Huang, E. G. Krebs

         Pages 175-184

      4. The Effect of Phosphorylation of Structural Muscle Proteins on the Actomyosin ATPase

         • E. Pratje, L. M. G. Heilmeyer Jr.

         Pages 185-195

      5. Phosphorylation of a Dogfish Skeletal Muscle Protein Related to Parvalbumin

         • H. E. Blum, S. Pocinwong, E. H. Fischer

         Pages 197-208

The First International Symposium on the Metabolic Interconversion of Enzymes was held in Santa Margherita Ligure, Italy, in May, 1970, under the direction of Professor G. Bonsignore. Because of rapid developments in this field, a second Symposium was organized a year and a half later in Rottach-Egern, Germany (October, 1971) by Professors E. He1mreich, H. Holzer and O. Wieland. At that time, so much new information had accumulated that it was decided to repeat such conferences approx­ imately every other year; the United States was chosen as the next site. This publi­ cation reports the Proceedings of the Third International Symposium on the Metabolic Interconversion of Enzymes held at the Battelle Seattle Research Center, Seattle, Washington, June 5 - 8, 1973. The conferences were originally designed to examine the control of metabolic reactions by covalent modification of certain key enzymes. Covalent, as opposed to allosteric or metabolic, regulation had first been recognized some fifteen years be­ fore. Initially thought to represent an added sophistication in regulatory processes possibly reserved to higher organisms, covalent regulation has now been found in both prokaryotes and eukaryotes. Those early studies in covalent modification revealed for the first time the existence of special "converter" enzymes whose purpose in life is to switch other molecules from one state of activity to another.

• Enzymes
• Fischer
• Krebs
• cancer
• eukaryotes

• Department of Biochemistry, University of Washington, Seattle, USA

  E. H. Fischer, H. Neurath

• Department of Biological Chemistry, University of California, School of Medicine, Davis, USA

  E. G. Krebs

• National Institutes of Health, Bethesda, USA

  E. R. Stadtman

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