Bacterial Infection: Close Encounters at the Host Pathogen Interface

1. Front Matter

   Pages I-IX

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2. In Vivo Gene Expression: Contributions to Infection, Virulence, and Pathogenesis

   • C. P. Conner, D. M. Heithoff, M. J. Mahan

   Pages 1-12

3. Anthrax Pathogenesis and Host Response

   • P. Hanna

   Pages 13-35

4. New Insights into the Genetics and Regulation of Expression of Clostridium perfringens Enterotoxin

   • B. A. McClane

   Pages 37-55

5. Identification of Virulence Determinants in Pathogenic Mycobacteria

   • J. E. Clark-Curtiss

   Pages 57-79

6. Mechanisms of Pathogenesis of Staphylococcal and Streptococcal Superantigens

   • J. V. Rago, P. M. Schlievert

   Pages 81-97

7. Intracellular Multiplication of Legionella pneumophila: Human Pathogen or Accidental Tourist?

   • H. A. Shuman, M. Purcell, G. Segal, L. Hales, L. A. Wiater

   Pages 99-112

8. Fe(III) Periplasm-to-Cytosol Transporters of Gram-Negative Pathogens

   • T. A. Mietzner, S. B. Tencza, P. Adhikari, K. G. Vaughan, A. J. Nowalk

   Pages 113-135

9. Molecular Pathogenesis of Urinary Tract Infections

   • S. E. F. D’Orazio, C. M. Collins

   Pages 137-164

10. Back Matter

    Pages 165-173

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When it comes to bacterial disease, we are living in a state of false security. Antibiotics have indeed brought unprecedented health benefits, protection from and cure of bacterial diseases during the past 50 years. But there are ominous signs that the fortress and the defenses built on antibiotics are crumbling. They are crum­ bling because we wittingly or unwittingly created selective con­ ditions for the emergence of superior pathogens that can no longer be controlled by antibiotics. There are numerous warnings. After a long period of eclipse tuberculosis has now emerged as a serious threat unchecked by antibiotic treatment. Recent years have seen reports of cholera epidemics, of anthrax infections, of serious problems with Salmonella and even with E. coli, just to name a few. Mankind is in a race with microbial invaders. The challenge is to anticipate and respond to developments that affect the precarious balance between man and microbe. This will re­ quire new knowledge and it will take time for an effective appli­ cation of that knowledge.

• antibiotic
• antibiotics
• antigen
• bacteria
• bacterial infection
• gene
• gene expression
• genetics
• infection
• infections
• microbe
• pathogenesis
• regulation
• toxin
• virology

• Division of Oncovirology, BCC 239, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

  Peter K. Vogt

• Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, USA

  Michael J. Mahan

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