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Isolation, Characterization and Utilization of CNS Stem Cells

  • Conference proceedings
  • © 1997

Overview

Editors:
  1. F. H. Gage

    1. Laboratory of Genetics, The Salk Institute for Biological Studies, San Diego, USA

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  2. Y. Christen

    1. Fondation IPSEN, Paris, Cedex 16, France

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Research and Perspectives in Neurosciences (NEUROSCIENCE)

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Table of contents (11 papers)

  1. Front Matter

    Pages i-vii
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  2. Stem Cells: The Lessons from Hematopoieses

    • I. L. Weissman
    Pages 1-8

  3. NRSF: A Coordinate Repressor of Neuron-Specific Genes Expressed in CNS Neural Progenitor Cells

    • C. J. Schoenherr, D. J. Anderson
    Pages 9-27

  4. Segregation of Cell Lineages in the Avian Neural Crest

    • E. Dupin, C. Ziller, N. M. Le Douarin
    Pages 29-42

  5. Comparative Strategies of Subependymal Neurogenesis in the Adult Forebrain

    • S. A. Goldman
    Pages 43-65

  6. Characterization of Neuronal Progenitor Cells of the Neonatal Forebrain

    • M. B. Luskin, T. Zigova, R. Betarbet, B. J. Soteres
    Pages 67-86

  7. Neurogenesis in the Adult Brain: Prospects for Brain Repair

    • A. Alvarez-Buylla
    Pages 87-100

  8. The Oligodendrocyte-Type-2 Astrocyte Lineage: In vitro and in vivo Studies on Development, Tissue Repair and Neoplasia

    • M. Noble
    Pages 101-128

  9. Neurogenesis in the Adult Brain: Lessons Learned from the Studies of Progenitor Cells from the Embryonic and Adult Central Nervous Systems

    • J. Ray, T. D. Palmer, J. Suhonen, J. Takahashi, F. H. Gage
    Pages 129-149

  10. Use of Conditionally Immortalized Neural Progenitors for Transplantation and Gene Transfer to the CNS

    • A. Martinez-Serrano, C. Lundberg, A. Björklund
    Pages 151-168

  11. The Origins of the Central Nervous System

    • R. McKay
    Pages 169-172

  12. Transplantation and Differentiation of Neural “Stem-Like” Cells: Possible Insights Into Development and Therapeutic Potential

    • E. Y. Snyder, J. D. Flax, B. D. Yandava, K. I. Park, S. Liu, C. M. Rosario et al.
    Pages 173-196

  13. Back Matter

    Pages 197-199
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Keywords

About this book

This volume is based on a meeting of the Fondation IPSEN, held in Paris on Sep­ tember 18, 1995 to address the main issues of nervous system stem cells biology. Cell replacement in the adult mammals is not unusual outside the nervous sys­ tem. In fact, the nervous system is unique in lacking the ability to replace cells, following damage. Most neurons, in the adult central nervous system are termin­ of the organism and are not replaced ally differentiated, exist through the life when they die. There are, however, regions of the postnatal brain that continue to produce new neurons, but the fate and longevity of those cells are not well known. Evidence exists that small populations of neurons continue to be born in the adult ventricular zone, olfactory epithelium and hippocampus. In the adult hippocampus, newly born neurons originate from putative stem cells that exist in the sub granular zone of the dentate gyrus. Progeny of these putative stem cells differentiate into neurons in the granular layer within a month of the cells' birth, and this late neurogenesis continues throughout the adult life of the rodent. By understanding the nature of progenitor cells present in the embryonic and adult brains, the change in their population dynamics during development, and the factors that influence their proliferation, fate choice and differentiation, it may be possible to develop a strategy to manipulate cells in situ to treat neuro­ degenerative diseases or the injured adult brain.

Editors and Affiliations

  • Laboratory of Genetics, The Salk Institute for Biological Studies, San Diego, USA

    F. H. Gage

  • Fondation IPSEN, Paris, Cedex 16, France

    Y. Christen

Bibliographic Information

  • Book Title: Isolation, Characterization and Utilization of CNS Stem Cells

  • Editors: F. H. Gage, Y. Christen

  • Series Title: Research and Perspectives in Neurosciences

  • DOI: https://doi.org/10.1007/978-3-642-80308-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-642-80310-9Published: 22 December 2011

  • eBook ISBN: 978-3-642-80308-6Published: 06 December 2012

  • Series ISSN: 0945-6082

  • Series E-ISSN: 2196-3096

  • Edition Number: 1

  • Number of Pages: VII, 198

  • Topics: Neurosciences

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