Overview
- Editors:
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E. T. Rietschel
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Forschungszentrum Borstel, Zentrum für Medizin und Biowissenschaften, Borstel, Germany
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Hermann Wagner
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Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, München, Germany
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Table of contents (14 chapters)
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- E. T. Rietschel, H. Brade, O. Holst, L. Brade, S. Müller-Loennies, U. Mamat et al.
Pages 39-81
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- K. Heeg, T. Miethke, H. Wagner
Pages 83-100
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- S. Bhakdi, I. Walev, D. Jonas, M. Palmer, U. Weller, N. Suttorp et al.
Pages 101-118
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- D. Pajkrt, S. J. H. van Deventer
Pages 119-132
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- L. G. Thus, A. B. J. Groeneveld, C. E. Hack
Pages 209-237
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- S. Bahrami, H. Redl, Y.-M. Yao, G. Schlag
Pages 239-258
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- D. Heumann, M. P. Glauser
Pages 299-311
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Back Matter
Pages 313-324
About this book
Severe sepsis and septic shock are the most serious compli cations of bacterial infections. Both gram-positive and gram negative bacteria can trigger these extreme inflammatory re sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan isms. At this stage, the editors of the present volume of Current Topics in Microbiology and Immunology considered it would be rewarding to compile a volume summarizing our present basic and clinical knowledge on sepsis. Our particular gratitude extends to those international experts who have followed our invitation and elaborated on particular areas of the basic and clinical aspects of this field.
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Editors and Affiliations
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Forschungszentrum Borstel, Zentrum für Medizin und Biowissenschaften, Borstel, Germany
E. T. Rietschel
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Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, München, Germany
Hermann Wagner
