Tuberculosis

1. Front Matter

   Pages I-XI

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2. Mycobacterium tuberculosis Cell Envelope

   • R. E. Lee, P. J. Brennan, G. S. Besra

   Pages 1-27

3. The Molecular Genetics of Mycobacterium tuberculosis

   • G. F. Hatfull

   Pages 29-47

4. Mechanisms of Drug Resistance in Mycobacterium tuberculosis

   • B. Heym, W. Philipp, S. T. Cole

   Pages 49-69

5. Entry of Mycobacterium tuberculosis into Mononuclear Phagocytes

   • L. S. Schlesinger

   Pages 71-96

6. In Vitro Interaction of Mycobacterium tuberculosis and Macrophages: Activation of Anti-mycobacterial Activity of Macrophages and Mechanisms of Anti-mycobacterial Activity

   • L. O’Brien, B. Roberts, P. W. Andrew

   Pages 97-130

7. Virulence Determinants of Mycobacterium tuberculosis

   • F. D. Quinn, G. W. Newman, C. H. King

   Pages 131-156

8. Pathogenesis of Experimental Tuberculosis in Animal Models

   • D. N. McMurray, F. M. Collins, A. M. Dannenberg Jr., D. W. Smith

   Pages 157-179

9. Immune Responses in Animal Models

   • I. M. Orme

   Pages 181-196

10. Human Cellular Immune Responses to Mycobacterium tuberculosis

    • P. F. Barnes, R. L. Modlin

    Pages 197-219

11. Mechanisms of Anergy in Tuberculosis

    • Z. Toossi, J. J. Ellner

    Pages 221-238

12. The Koch Phenomenon and the Immunopathology of Tuberculosis

    • G. A. W. Rook, J. L. Stanford

    Pages 239-262

13. BCG Vaccination in the Control of Tuberculosis

    • R. E. Huebner

    Pages 263-282

14. Functional T Cell Subsets in Mycobacterial and Listerial Infections: Lessons from Other Intracellular Pathogens

    • G. Szalay, S. H. E. Kaufmann

    Pages 283-302

15. Back Matter

    Pages 303-311

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Tuberculosis has plagued mankind since prehistoric times and is still an important source of morbidity and mortality, with particularly devastating effects in developing and tropical countries. Tuberculosis results from an infection with Myeo­ baeterium tubereu/osis, and the World Health Organization estimates that perhaps as much as one-third of the world's population or approximately 1. 9 billion persons are or have been infected with M. tubereu/osis. Each year, there are 8-10 million new cases of tuberculosis and about 3 million deaths due to it. Indeed, tuberculosis is the leading cause of death in adults due to a single infectious agent and accounts for ap­ proximately 26% of all preventable adult deaths in the world. In addition, tuberculosis is an enormous social and economic problem because approximately 95% of new cases occur in developing countries and because about 80% of tuberculosis cases affect persons of child-bearing age and du ring their most economically productive years (ages 15-59). Tuberculosis has also re-emerged as an important public health problem in many developed countries. For example, between 1985 and 1992, the number of tuberculosis cases reported to the United States Centers for Disease Control and Prevention increased by more than 20%. Similarly, Austria experienced a 5% increase in tuberculosis cases from 1987 to 1991, Ireland a 9% increase from 1988 to 1991, Denmark a 20% increase from 1987 to 1992, and Italy a 27% increase from 1988 to 1992.

• bacteria
• drug resistance
• genetics
• immune response
• immune system
• immunology
• infection
• macrophages
• molecular biology
• molecular genetics
• parasite
• pathogenesis
• pathology
• tuberculosis
• vaccination

"...an excellent treatise dealing comprehensively with all pertinent areas of mycobacteriology, by the leading workers in the field. It is an essential purchase for 'Mycobacteriologists'and is an ideal reference book for all microbiologists wishing to understand the pathogenesis of M. tuberculosis." Brit. Jnl of Biomedical Science'

• Department of Health and Human Services, Immunology and Molecular Pathogenesis Section, Division of AIDS, STD and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, USA

  Thomas M. Shinnick

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