Morphogenesis and Maturation of Retroviruses

1. Front Matter

   Pages I-XI

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2. Comparative Morphology and Structural Classification of Retroviruses

   • M. V. Nermut, D. J. Hockley

   Pages 1-24

3. Intracellular Transport of Retroviral Capsid Components

   • H.-G. Kräusslich, R. Welker

   Pages 25-63

4. Dynamic Interactions of the Gag Polyprotein

   • R. C. Craven, L. J. Parent

   Pages 65-94

5. Proteolytic Processing and Particle Maturation

   • V. M. Vogt

   Pages 95-131

6. Maturation and Assembly of Retroviral Glycoproteins

   • D. Einfeld

   Pages 133-176

7. RNA Packaging

   • R. Berkowitz, J. Fisher, S. P. Goff

   Pages 177-218

8. Role of Auxiliary Proteins in Retroviral Morphogenesis

   • é. A. Cohen, R. A. Subbramanian, H. G. Göttlinger

   Pages 219-235

9. Use of Heterologous Expression Systems to Study Retroviral Morphogenesis

   • P. Boulanger, I. Jones

   Pages 237-260

10. Morphogenesis at the Retrotransposon-Retrovirus Interface: Gypsy and Copia Families in Yeast and Drosophila

    • S. B. Sandmeyer, T. M. Menees

    Pages 261-296

11. Hepatitis B Virus Morphogenesis

    • M. Nassal

    Pages 297-337

12. Back Matter

    Pages 339-344

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Retroviruses arguably belong to the most fascinating of all viruses because of their unusual and highly efficient mode of replication involving reverse transcription and integration of the viral genome and a complex system of transcriptional and post­ transcriptional regulatory mechanisms. The importance of ret­ roviruses as human and animal pathogens has also enhanced scientific and medical interest in this diverse group of viruses and has spurred an intensive search for novel and improved antiviral agents. More recently, analysis of retroviral replication and in particular understanding the formation and composition of the virus particle has received additional attention because of the promise of retroviral vectors as vehicles for human somatic gene therapy. Many recent advances have been made in our understanding of the molecular mechanisms governing as­ sembly and release of infectious retrovirus particles. This book attempts to summarize these recent developments and to provide an overview of our current knowledge on retrovirus particle formation. The individual chapters of the book deal with specific steps in the pathway of retroviral morphogenesis and maturation, starting at the time when the components of the virus have been synthesized within the infected cell and ending once the infectious virion has been released from the cell. An introductory chapter provides a comparative description of the structure and morphology of various retroviruses.

• Drosophila
• RNA
• Viren
• cell
• glycoprotein
• hepatitis
• hepatitis B
• morphogenesis
• morphology
• protein
• proteins
• retroviruses
• virus
• viruses
• yeast

"The authors of this exemplary volume provide the most up-to-date review of their subject...The writing is precise and dynamic, supported by judiciously chosen illustrations...a wonderful contribution to a rapidly moving field. It will be enjoyed by students and teachers alike and will serve as a precious source of reference for even the most seasoned of researchers." Trends in Microbiology

• Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Hamburg, Germany

  Hans-Georg Kräusslich

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