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Apolipoprotein E and Alzheimer’s Disease

  • Conference proceedings
  • © 1996

Overview

Editors:
  1. A. D. Roses

    1. Joseph and Kathleen Bryan Alzheimer’s Disease Research Center Departments of Medicine (Neurology) and Neurobiology, Duke University Medical Center, Durham, USA

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  2. K. Weisgraber

    1. Gladstone Institute of Cardiovascular Disease Department of Pathology, Cardiovascular Research Institute, University of California, San Francisco, USA

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  3. Y. Christen

    1. Fondation IPSEN, Paris, France

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Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (16 papers)

  1. Front Matter

    Pages I-XX
    Download chapter PDF

  2. Apolipoprotein E and Alzheimer’s Disease: State of the Field After Two Years

    • A. D. Roses, W. J. Strittmatter, A. M. Saunders, D. E. Schmechel, M. A. Pericak-Vance
    Pages 1-10

  3. Role of Apolipoprotein E in Alzheimer’s Disease: Clues from its Structure

    • K. H. Weisgraber, L. M. Dong
    Pages 11-19

  4. Apolipoprotein E4, Cholinergic Integrity, Synaptic Plasticity and Alzheimer’s Disease

    • J. Poirier, M.-C. Delisle, R. Quirion, I. Aubert, J. Rocheford, I. Rousse et al.
    Pages 20-28

  5. Pattern of Apolipoprotein E Immunoreactivity During Brain Aging

    • D. E. Schmechel, M. O. Tiller, P. Tong, M. McSwain, S.-H. Han, R. Ange et al.
    Pages 29-48

  6. Apolipoprotein E: Structure, Function, and Possible Roles in Modulating Neurite Extension and Cytoskeletal Activity

    • R. W. Mahley, B. P. Nathan, S. Bellosta, R. E. Pitas
    Pages 49-58

  7. Apolipoprotein E Role in Maintaining the Integrity of the Aging Central Nervous System

    • E. Masliah, M. Mallory, M. Alford, I. Veinbergs, A. D. Roses
    Pages 59-73

  8. Very Low Density Lipoprotein Receptor and Alzheimer’s Disease

    • K. Ikeda, T. Aizawa, S. Haga, N. Otsuka, M. Mizuguchi, Y. Namba et al.
    Pages 74-96

  9. Apolipoprotein E and Apolipoprotein E Receptors in the Central Nervous System: Relationship with Alzheimer’s Disease

    • B. T. Hyman, G. W. Rebeck, R. Christie, K. Page, M. Irizarry, D. K. Strickland
    Pages 97-102

  10. Tau Protein and the Neurofibrillary Pathology of Alzheimer’s Disease

    • M. Goedert
    Pages 103-125

  11. Tau Protein and Alzheimer Paired Helical Filament Assembly: Interacting Domains and Control Residues

    • E. Mandelkow, O. Schweers, J. Biernat, B. Trinczek, G. Drewes, E.-M. Mandelkow
    Pages 126-135

  12. The βA4 Amyloid Peptide Enhances Cellular Uptake of Apolipoprotein E-Containing Lipoproteins by the Low-Density Lipoprotein Receptor-Related Protein/α 2-Macroglobulin Receptor

    • H. Scharnagl, K. Winkler, M. Hüttinger, D. Wittmann, M. Nauck, H. Wieland et al.
    Pages 136-144

  13. Interactions of Apolipoprotein E with Microtubule-Associated Proteins

    • W. J. Strittmatter, V. de Serrano, D. Y. Huang, M. E. Martin, A. D. Roses, A. M. Saunders
    Pages 145-150

  14. Chaperoning Amyloid in Alzheimer’s Disease: The Art of Avoiding Sticky Situations?

    • B. Frangione, E. M. Castaño, F. Prelli, C. Soto, J. Ghiso, T. Wisniewski
    Pages 151-160

  15. Apolipoprotein E Oxidation and Functional Consequences

    • B. Leininger-Muller, C. Jolivalt, T. Pillot, P. Lagrange, M. H. Livertoux, M. C. Grassiot et al.
    Pages 161-169

  16. Ethnic Variation in the Association Between APOE-ε4 and Alzheimer’s Disease: A Follow-up Study

    • G. Maestre, P. Schofield, M. Chun, M.-X. Tang, B. Tycko, R. Mayeux
    Pages 170-179

  17. The Search for Additional Alzheimer’s Disease Genes

    • M. A. Pericak-Vance, P. M. Conneally, G. W. Small, A. M. Saunders, L. Yamaoka, P. C. Gaskell et al.
    Pages 180-186

  18. Back Matter

    Pages 187-188
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Keywords

About this book

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Editors and Affiliations

  • Joseph and Kathleen Bryan Alzheimer’s Disease Research Center Departments of Medicine (Neurology) and Neurobiology, Duke University Medical Center, Durham, USA

    A. D. Roses

  • Gladstone Institute of Cardiovascular Disease Department of Pathology, Cardiovascular Research Institute, University of California, San Francisco, USA

    K. Weisgraber

  • Fondation IPSEN, Paris, France

    Y. Christen

Bibliographic Information

  • Book Title: Apolipoprotein E and Alzheimer’s Disease

  • Editors: A. D. Roses, K. Weisgraber, Y. Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-642-80109-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-642-80111-2Published: 31 December 2011

  • eBook ISBN: 978-3-642-80109-9Published: 06 December 2012

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XX, 188

  • Number of Illustrations: 1 illustrations in colour

  • Topics: Neurosciences

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