Apolipoprotein E and Alzheimer’s Disease

1. Front Matter

   Pages I-XX

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2. Apolipoprotein E and Alzheimer’s Disease: State of the Field After Two Years

   • A. D. Roses, W. J. Strittmatter, A. M. Saunders, D. E. Schmechel, M. A. Pericak-Vance

   Pages 1-10

3. Role of Apolipoprotein E in Alzheimer’s Disease: Clues from its Structure

   • K. H. Weisgraber, L. M. Dong

   Pages 11-19

4. Apolipoprotein E4, Cholinergic Integrity, Synaptic Plasticity and Alzheimer’s Disease

   • J. Poirier, M.-C. Delisle, R. Quirion, I. Aubert, J. Rocheford, I. Rousse et al.

   Pages 20-28

5. Pattern of Apolipoprotein E Immunoreactivity During Brain Aging

   • D. E. Schmechel, M. O. Tiller, P. Tong, M. McSwain, S.-H. Han, R. Ange et al.

   Pages 29-48

6. Apolipoprotein E: Structure, Function, and Possible Roles in Modulating Neurite Extension and Cytoskeletal Activity

   • R. W. Mahley, B. P. Nathan, S. Bellosta, R. E. Pitas

   Pages 49-58

7. Apolipoprotein E Role in Maintaining the Integrity of the Aging Central Nervous System

   • E. Masliah, M. Mallory, M. Alford, I. Veinbergs, A. D. Roses

   Pages 59-73

8. Very Low Density Lipoprotein Receptor and Alzheimer’s Disease

   • K. Ikeda, T. Aizawa, S. Haga, N. Otsuka, M. Mizuguchi, Y. Namba et al.

   Pages 74-96

9. Apolipoprotein E and Apolipoprotein E Receptors in the Central Nervous System: Relationship with Alzheimer’s Disease

   • B. T. Hyman, G. W. Rebeck, R. Christie, K. Page, M. Irizarry, D. K. Strickland

   Pages 97-102

10. Tau Protein and the Neurofibrillary Pathology of Alzheimer’s Disease

    • M. Goedert

    Pages 103-125

11. Tau Protein and Alzheimer Paired Helical Filament Assembly: Interacting Domains and Control Residues

    • E. Mandelkow, O. Schweers, J. Biernat, B. Trinczek, G. Drewes, E.-M. Mandelkow

    Pages 126-135

12. The βA4 Amyloid Peptide Enhances Cellular Uptake of Apolipoprotein E-Containing Lipoproteins by the Low-Density Lipoprotein Receptor-Related Protein/α ₂-Macroglobulin Receptor

    • H. Scharnagl, K. Winkler, M. Hüttinger, D. Wittmann, M. Nauck, H. Wieland et al.

    Pages 136-144

13. Interactions of Apolipoprotein E with Microtubule-Associated Proteins

    • W. J. Strittmatter, V. de Serrano, D. Y. Huang, M. E. Martin, A. D. Roses, A. M. Saunders

    Pages 145-150

14. Chaperoning Amyloid in Alzheimer’s Disease: The Art of Avoiding Sticky Situations?

    • B. Frangione, E. M. Castaño, F. Prelli, C. Soto, J. Ghiso, T. Wisniewski

    Pages 151-160

15. Apolipoprotein E Oxidation and Functional Consequences

    • B. Leininger-Muller, C. Jolivalt, T. Pillot, P. Lagrange, M. H. Livertoux, M. C. Grassiot et al.

    Pages 161-169

16. Ethnic Variation in the Association Between APOE-ε4 and Alzheimer’s Disease: A Follow-up Study

    • G. Maestre, P. Schofield, M. Chun, M.-X. Tang, B. Tycko, R. Mayeux

    Pages 170-179

17. The Search for Additional Alzheimer’s Disease Genes

    • M. A. Pericak-Vance, P. M. Conneally, G. W. Small, A. M. Saunders, L. Yamaoka, P. C. Gaskell et al.

    Pages 180-186

18. Back Matter

    Pages 187-188

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There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

• Alzheimer's disease
• Alzheimer´s disease
• Brain aging
• biochemistry
• brain
• central nervous system
• lipoprotein
• nervous system
• neuropathology

• Joseph and Kathleen Bryan Alzheimer’s Disease Research Center Departments of Medicine (Neurology) and Neurobiology, Duke University Medical Center, Durham, USA

  A. D. Roses

• Gladstone Institute of Cardiovascular Disease Department of Pathology, Cardiovascular Research Institute, University of California, San Francisco, USA

  K. Weisgraber

• Fondation IPSEN, Paris, France

  Y. Christen

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