Immunology and Developmental Biology of the Chicken

1. Front Matter

   Pages I-IX

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2. Why I Think the Chicken Should Survive in Immunology and Developmental Biology

   • M. Simonsen

   Pages 1-6

3. Postrearrangement Diversification Processes in Gut-Associated Lymphoid Tissues

   • C.-A. Reynaud, J.-C. Weill

   Pages 7-15

4. Current Concepts in Chicken B Cell Development

   • P. E. Funk, C. B. Thompson

   Pages 17-28

5. Evidence for Phenotypic Heterogeneity Among B Cells Emigrating from the Bursa of Fabricius: A Reflection of Functional Diversity?

   • E. Paramithiotis, M. J. H. Ratcliffe

   Pages 29-36

6. T Cell Receptors and T Cell Development

   • C. H. Chen, A. Six, T. Kubota, S. Tsuji, F.-K. Kong, T. W. F. Göbel et al.

   Pages 37-53

7. Chicken γδ T Cells

   • F. J. Sanchez-Garcia, W. T. McCormack

   Pages 55-69

8. T Cell Subsets and the Activation of γδ T Cells

   • T. P. Arstila

   Pages 71-77

9. T Cell Migration During Ontogeny and T Cell Repertoire Generation

   • D. Dunon, B. A. Imhof

   Pages 79-93

10. The Avian Model in the Study of Tolerance to Self

    • C. Corbel

    Pages 95-106

11. Avian Natural Killer Cells

    • T. W. F. Göbel, C. H. Chen, M. D. Cooper

    Pages 107-117

12. Ontogeny of Hematopoiesis in the Avian Embryo: A General Paradigm

    • F. Dieterlen-Lievre, I. Godin, L. Pardanaud

    Pages 119-128

13. Chicken MHC Molecules, Disease Resistance and the Evolutionary Origin of Birds

    • J. Kaufman, H. J. Wallny

    Pages 129-141

14. Acute Avian Leukemia Viruses as Tools to Study Hematopoietic Cell Differentiation

    • K. M. McNagny, T. Graf

    Pages 143-162

15. Control of the Differentiation Commitment by Nuclear Hormone Receptors in Chicken Erythrocytic Progenitor Cells

    • J. Samarut

    Pages 163-173

16. Cell Cycle Regulation and Erythroid Differentiation

    • E. W. Müllner, H. Dolznig, H. Beug

    Pages 175-194

17. Chick Stem Cells

    • C. D. Stern

    Pages 195-206

18. Modulations of Cellular Interactions During Development of the Neural Crest: Role of Growth Factors and Adhesion Molecules

    • J. L. Duband, M. Delannet, F. Monier, S. Garret, N. Desban

    Pages 207-227

19. Establishment of Pathways in the Developing Neural System

    • M. Chiquet

    Pages 229-238

20. Limb Development

    • P. Francis-West, C. Tickle

    Pages 239-259

The chicken is a useful model for research into the basic features of immunology because its immune system functions in a way similar to that of human beings and because the chicken embryo is easily accessed experimentally. This book is a collection of comprehen­ sive articles updating chicken embryogenesis and immunology. It is now clear that it is possible to produce transgenic chickens by embryonic stem cell manipulation and transfer into the oocyte. Alternatively, the chick offers us the possibility of producing somatic chimeras by manipulating embryonic cells at the primitive streak or earlier stages. Working with later em­ bryos, we can learn the principles involved in the positioning of organ anlagen such as the limb bud. It is shown in this book that these structures are formed by appropriate cell and tissue arrangements driven by molecular factors. Work on the chicken has contributed substantially to our understanding of basic immunology, including the graft-vs. -host reaction, the clonal reactivity of immunocompetent cells, sepa­ ration of the T and B cell lineages, somatic diversification of the B cell repertoire by immunoglobulin (Ig) class switching, anti­ body diversification, Ig gene conversion, and the origin of the hematopoietic stem cell precursor of lymphoid and myeloid cells. Hematopoietic stem cells emerge successively from sev­ eral embryonic sites such as the yolk sac, the aorta, and the mesentery near the aorta.

• Hämatopoese
• Immunologie
• Monoclonal Antibodies
• T cell
• antibody
• biology
• cell
• development
• developmental biology
• embryo
• hematopoiesis
• immunology

• Basel Institute for Immunology, Basel, Switzerland

  Olli Vainio, Beat A. Imhof

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