New Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors

1. Front Matter

   Pages I-XII

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2. Basic Research

   1. The Molecular Biology of Esophageal Carcinoma

      • S. J. Meltzer

      Pages 1-8

   2. Preventing Colorectal Cancer

      • E. R. Greenberg

      Pages 9-18

   3. Adhesion Receptors in Malignant Transformation and Dissemination of Gastrointestinal Tumors

      • M. Streit, R. Schmidt, R. U. Hilgenfeld, E. Thiel, E. D. Kreuser

      Pages 19-50

   4. Human Gene Therapy in Gastrointestinal Diseases: In Vivo and In Vitro Approaches

      • R. Kaiser, E. Thiel, E.-D. Kreuser

      Pages 51-61

   5. Signal Transduction as Target of Gene Therapy

      • K. Moelling, B. Strack, G. Radziwill

      Pages 63-71

3. Diagnostic Tools

   1. Prognostic Significance of Molecular Biological and Immunohistological Parameters in Gastrointestinal Carcinomas

      • J. Rüschoff, T. Bocker, P. Vogel, J. Schlegel

      Pages 73-88

   2. Molecular Mechanisms and Possibilities of Overcoming Drug Resistance in Gastrointestinal Tumors

      • M. Dietel

      Pages 89-101

   3. Radiological Modalities in the Staging of Colorectal Tumors: New Perspectives for Increasing Accuracy

      • T. J. Vogl, W. Pegios, M. G. Mack, M. Rausch, H. Hintze, M. Hünerbein et al.

      Pages 103-120

   4. Immunological and Molecular Classification of Mucosa-Associated Lymphoid Tissue Lymphoma

      • A. Schmitt-Gräff

      Pages 121-136

   5. Somatostatin Receptor Scintigraphy in the Diagnosis of Neuroendocrine Gastroenteropancreatic Tumors

      • M. Bäder, K. Koppenhagen

      Pages 137-162

4. Therapeutic Approaches

   1. Basis and Consequences of Primary and Secondary Prevention of Gastrointestinal Tumors

      • P. Goldin-Lang, E.-D. Kreuser, H. J. F. Zunft

      Pages 163-192

   2. Drug Therapy in Metastatic Neuroendocrine Tumors of the Gastroenteropancreatic System

      • S. Faiss, H. Scherübl, E. O. Riecken, B. Wiedenmann

      Pages 193-207

   3. Laparoscopic Lymph Node Assessment in Pretherapeutic Staging of Gastric and Esophageal Cancer

      • B. Rau, M. Hünerbein, B. Reingruber, P. Hohenberger, P. M. Schlag

      Pages 209-215

   4. Radiation Therapy Alone or Combined with Chemotherapy in the Treatment of Esophageal Cancer

      • B D Minsky

      Pages 217-235

   5. Preoperative Chemotherapy in Gastric Cancer

      • H. Wilke, H. J. Meyer, U. Fink

      Pages 237-248

   6. Current Aspects of Sphincter Preservation in the Surgical Therapy of Rectal Cancer

      • P. M. Schlag

      Pages 249-256

   7. Preoperative and Postoperative Radiotherapy in Rectal Carcinoma

      • V. Budach, L. Schlenger, P. Feyer

      Pages 257-279

   8. Hyperthermia in the Multimodal Therapy of Advanced Rectal Carcinomas

      • P. Wust, J. Gellermann, B. Rau, J. Löffel, A. Speidel, H. Stahl et al.

      Pages 281-309

   9. Adjuvant Treatment of Colon and Rectal Cancer: Impact of Chemotherapy, Radiotherapy, and Immunotherapy on Routine Postsurgical Patient Management

      • K. H. Link, L. Staib, E.-D. Kreuser, H. G. Beger

      Pages 311-352

This volume focuses on new and exciting approaches in the molecular and clinical management of gastrointestinal tumors. The first part presents recent insights into carcinogenesis, including alterations in cyclins and adhesion receptors, molecular structures which might be new targets of gene therapy. The second part of the volume offers new diagnostic tools, such as receptors for gastrointestinal hormones, proliferation markers, tumor suppressor proteins, and the multiple drug resistance gene, predicting response to therapy and prognosis in gastrointestinal tumors. The third part gives an update of successful approaches in primary and secondary prevention of colorectal carcinoma. Nutritional factors and pharmacologic agents can clearly decrease the risk, and fecal occult blood tests and endoscopy can reduce the mortality in colorectal carcinoma. Laparoscopic staging with subsequent biopsy of suspicious lymph nodes provides essential information in esophageal and gastric cancer. In locally advanced gastric cancer, preoperative chemotherapy provides sufficient evidence to investigate this approach as compared to primary surgery. Standards have recently been established in the adjuvant treatment of patients with gastrointestinal carcinoma, and promising new drugs, including monoclonal antibodies, thymidylate synthase, and topoisomerase inhibitors, as well as taxoids, are currently being tested in phase I, II, and III trials of gastrointestinal tumors.

• Tumor
• cancer
• carcinogenesis
• carcinoma
• chemotherapy
• classification
• gene therapy
• hormones
• immunotherapy
• lymphoma
• molecular biology
• neuroendocrine tumor
• prevention
• radiation therapy
• radiotherapy
• abdominal surgery

• Fachbereich Humanmedizin, Univ.-Klinikum Benjamin Franklin, Medizinische Klinik und Poliklinik, Schwerpunkt Hämatologie und Onkologie, Freie Universität Berlin, Germany

  Ernst-D. Kreuser

• Robert-Rössle Klinik am Max-Delbrück-Centrum, Humboldt-Universität, Germany

  P. M. Schlag

Policies and ethics