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New Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors

  • Conference proceedings
  • © 1996

Overview

Editors:
  1. Ernst-D. Kreuser

    1. Fachbereich Humanmedizin, Univ.-Klinikum Benjamin Franklin, Medizinische Klinik und Poliklinik, Schwerpunkt Hämatologie und Onkologie, Freie Universität Berlin, Germany

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  2. P. M. Schlag

    1. Robert-Rössle Klinik am Max-Delbrück-Centrum, Humboldt-Universität, Germany

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 142)

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Table of contents (24 papers)

  1. Front Matter

    Pages I-XII
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  2. Basic Research

    1. The Molecular Biology of Esophageal Carcinoma

      • S. J. Meltzer
      Pages 1-8

    2. Preventing Colorectal Cancer

      • E. R. Greenberg
      Pages 9-18

    3. Adhesion Receptors in Malignant Transformation and Dissemination of Gastrointestinal Tumors

      • M. Streit, R. Schmidt, R. U. Hilgenfeld, E. Thiel, E. D. Kreuser
      Pages 19-50

    4. Human Gene Therapy in Gastrointestinal Diseases: In Vivo and In Vitro Approaches

      • R. Kaiser, E. Thiel, E.-D. Kreuser
      Pages 51-61

    5. Signal Transduction as Target of Gene Therapy

      • K. Moelling, B. Strack, G. Radziwill
      Pages 63-71

  4. Therapeutic Approaches

    1. Basis and Consequences of Primary and Secondary Prevention of Gastrointestinal Tumors

      • P. Goldin-Lang, E.-D. Kreuser, H. J. F. Zunft
      Pages 163-192

    2. Drug Therapy in Metastatic Neuroendocrine Tumors of the Gastroenteropancreatic System

      • S. Faiss, H. Scherübl, E. O. Riecken, B. Wiedenmann
      Pages 193-207

    3. Laparoscopic Lymph Node Assessment in Pretherapeutic Staging of Gastric and Esophageal Cancer

      • B. Rau, M. Hünerbein, B. Reingruber, P. Hohenberger, P. M. Schlag
      Pages 209-215

    4. Radiation Therapy Alone or Combined with Chemotherapy in the Treatment of Esophageal Cancer

      • B D Minsky
      Pages 217-235

    5. Preoperative Chemotherapy in Gastric Cancer

      • H. Wilke, H. J. Meyer, U. Fink
      Pages 237-248

    6. Current Aspects of Sphincter Preservation in the Surgical Therapy of Rectal Cancer

      • P. M. Schlag
      Pages 249-256

    7. Preoperative and Postoperative Radiotherapy in Rectal Carcinoma

      • V. Budach, L. Schlenger, P. Feyer
      Pages 257-279

    8. Hyperthermia in the Multimodal Therapy of Advanced Rectal Carcinomas

      • P. Wust, J. Gellermann, B. Rau, J. Löffel, A. Speidel, H. Stahl et al.
      Pages 281-309

    9. Adjuvant Treatment of Colon and Rectal Cancer: Impact of Chemotherapy, Radiotherapy, and Immunotherapy on Routine Postsurgical Patient Management

      • K. H. Link, L. Staib, E.-D. Kreuser, H. G. Beger
      Pages 311-352
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Keywords

About this book

This volume focuses on new and exciting approaches in the molecular and clinical management of gastrointestinal tumors. The first part presents recent insights into carcinogenesis, including alterations in cyclins and adhesion receptors, molecular structures which might be new targets of gene therapy. The second part of the volume offers new diagnostic tools, such as receptors for gastrointestinal hormones, proliferation markers, tumor suppressor proteins, and the multiple drug resistance gene, predicting response to therapy and prognosis in gastrointestinal tumors. The third part gives an update of successful approaches in primary and secondary prevention of colorectal carcinoma. Nutritional factors and pharmacologic agents can clearly decrease the risk, and fecal occult blood tests and endoscopy can reduce the mortality in colorectal carcinoma. Laparoscopic staging with subsequent biopsy of suspicious lymph nodes provides essential information in esophageal and gastric cancer. In locally advanced gastric cancer, preoperative chemotherapy provides sufficient evidence to investigate this approach as compared to primary surgery. Standards have recently been established in the adjuvant treatment of patients with gastrointestinal carcinoma, and promising new drugs, including monoclonal antibodies, thymidylate synthase, and topoisomerase inhibitors, as well as taxoids, are currently being tested in phase I, II, and III trials of gastrointestinal tumors.

Editors and Affiliations

  • Fachbereich Humanmedizin, Univ.-Klinikum Benjamin Franklin, Medizinische Klinik und Poliklinik, Schwerpunkt Hämatologie und Onkologie, Freie Universität Berlin, Germany

    Ernst-D. Kreuser

  • Robert-Rössle Klinik am Max-Delbrück-Centrum, Humboldt-Universität, Germany

    P. M. Schlag

Bibliographic Information

  • Book Title: New Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors

  • Editors: Ernst-D. Kreuser, P. M. Schlag

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-80035-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-642-80037-5Published: 22 December 2011

  • eBook ISBN: 978-3-642-80035-1Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XII, 439

  • Number of Illustrations: 9 illustrations in colour

  • Topics: Oncology, Abdominal Surgery, Imaging / Radiology

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