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Systemic Radiotherapy with Monoclonal Antibodies

Options and Problems

  • Conference proceedings
  • © 1996

Overview

Editors:
  1. Marie-Luise Sautter-Bihl

    1. Klinik für Strahlentherapie, Städt. Kliniken Karlsruhe, Karlsruhe, Germany

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  2. Heiner Bihl

    1. Klinik für Nuklearmedizin, Katharinenhospital Stuttgart, Stuttgart, Germany

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  3. Michael Wannenmacher

    1. Radiologische Klinik Abteilung für Klinische Radiologie, Heidelberg, Germany

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 141)

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Table of contents (13 papers)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. Monoclonal Antibodies in Tumor Therapy

    • S. Matzku
    Pages 1-8

  3. Experimental Radioimmunotherapy: Biological Effectiveness and Comparison with External Beam Radiation

    • D. J. Buchsbaum, P. L. Roberson
    Pages 9-18

  4. Higher Efficiency of 131I-Labeled Anti-Carcinoembryonic Antigen—Monoclonal Antibody F(ab′)2 as Compared to Intact Antibodies in Radioimmunotherapy of Established Human Colon Carcinoma Grafted in Nude Mice

    • F. Buchegger, J.-P. Mach, S. Folli, B. Delaloye, A. Bischof-Delaloye, A. Pèlegrin
    Pages 19-35

  5. Problems and Advances in the Dosimetry of Radionuclide Targeted Therapy

    • J. L. Humm
    Pages 37-65

  6. Minimal Residual Disease: a Target for Radioimmunotherapy with 131I-labeled Monoclonal Antibodies? Some Dosimetric Considerations

    • M.-L. Sautter-Bihl, G. Herbold, H. Bihl
    Pages 67-75

  7. Optimal Therapeutic Strategies for Radioimmunotherapy

    • J. A. O’Donoghue
    Pages 77-99

  8. Two Approaches for Enhancing Radioimmunotherapy: ∝ Emitters and Hyperthermia

    • M. R. Zalutsky, J. M. Schuster, P. K. Garg, G. E. Archer Jr., M. W. Dewhirst, D. D. Bigner
    Pages 101-122

  9. Can Preirradiation Enhance Tumor Uptake of Radiolabeled Pharmaceuticals? Experimental Data in a Mouse Neuroblastoma Xenograft System

    • M. L. Sautter-Bihl, H. Bihl
    Pages 123-135

  10. The Use of Radioimmunotherapy in Combination with Bioreductive Agents

    • V. K. Langmuir
    Pages 137-143

  11. Treatment of Diffuse Leptomeningeal Malignancy by Intrathecal Injection of 131I Radioimmunoconjugates

    • J. T. Kemshead, K. I. Hopkins, C. L. Chandler
    Pages 145-158

  12. The Treatment of Patients with Recurrent Malignant Gliomas with Intratumoral Radioimmunoconjugates

    • K. Hopkins, V. Papanastassiou, J. T. Kemshead
    Pages 159-175

  13. High Dose Radioimmunotherapy in Malignant Lymphoma

    • J. F. Eary, O. W. Press
    Pages 177-182

  14. The Use of Epidermal Growth Factor Receptor-425 Monoclonal Antibodies Radiolabeled with Iodine-125 in the Adjuvant Treatment of Patients with High Grade Gliomas of the Brain

    • C. T. Miyamoto, L. W. Brady, M. A. Rackover, J. Emrich, R. Class, H. Bender et al.
    Pages 183-192

  15. Back Matter

    Pages 193-197
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Keywords

About this book

Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio­ labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.

Reviews

"a timely and deliberately provocative new impetus to this long overdue discussion of promising, selective cancer treatment." Jnl. of the National Cancer Institute

Editors and Affiliations

  • Klinik für Strahlentherapie, Städt. Kliniken Karlsruhe, Karlsruhe, Germany

    Marie-Luise Sautter-Bihl

  • Klinik für Nuklearmedizin, Katharinenhospital Stuttgart, Stuttgart, Germany

    Heiner Bihl

  • Radiologische Klinik Abteilung für Klinische Radiologie, Heidelberg, Germany

    Michael Wannenmacher

Bibliographic Information

  • Book Title: Systemic Radiotherapy with Monoclonal Antibodies

  • Book Subtitle: Options and Problems

  • Editors: Marie-Luise Sautter-Bihl, Heiner Bihl, Michael Wannenmacher

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-79952-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-642-79954-9Published: 14 December 2011

  • eBook ISBN: 978-3-642-79952-5Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: IX, 198

  • Topics: Oncology, Radiotherapy

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