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The Endothelium in Cardiovascular Disease

Pathophysiology, Clinical Presentation and Pharmacotherapy

  • Book
  • © 1995

Overview

Editors:
  1. Thomas F. Lüscher

    1. Abteilung Kardiologie, Inselspital, Bern, Switzerland

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-XI
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  2. The Endothelium as a Regulator of Vascular Tone and Growth

    • T. F. Lüscher, G. Noll
    Pages 1-24

  3. Effects of Physical and Pharmacological Interventions on Circulating Endothelin-1 Levels in Humans

    • A. Morganti, F. Ghio, G. Gazzano
    Pages 25-32

  4. The Role of Endothelin in Congestive Heart Failure

    • A. L. Clavell, J. C. Burnett Jr.
    Pages 33-42

  5. Endothelin as a Regulator of Vascular Tone in Man: Studies in Upper Limb Resistance and Capacitance Vessels

    • D. J. Webb, W. G. Haynes, C. J. Ferro
    Pages 43-56

  6. Systemic and Endocrine Effects of Endothelin in Humans

    • H. Vierhapper
    Pages 57-65

  7. Endothelin in Hypertension and Vascular Hypertrophy: Experimental Studies

    • E. L. Schiffrin
    Pages 66-73

  8. Role of Endogenous Endothelin in Myocardial Ischemia and Nitric Oxide-Deficient Hypertension

    • V. Richard, M. Hogie, C. Thuillez
    Pages 74-83

  9. Endothelin and Renal Function: From Theory to Therapy

    • T. J. Rabelink, P. Morrison
    Pages 84-96

  10. The Endothelium and the Pathogenesis of Chronic Vascular Diseases:The Protective Role of Calcium Antagonists

    • H. Haller
    Pages 97-107

  11. Insulin and the Regulation of the Cardiovascular System: Role of the l-arginine Nitric Oxide Pathway and the Sympathetic Nervous System

    • U. Scherrer
    Pages 108-128

  12. Endothelin Receptor Antagonists as New Tools to Inhibit Endothelin induced Vasoconstriction in Humans: Comparison with Calcium Channel Blockers

    • R. R. Wenzel, T. F. Lüscher
    Pages 129-147

  13. Endothelial Dysfunction: Clinical Applicability of Calcium Antagonist Drugs

    • H. L. Elliott
    Pages 148-156

  14. Endothelin in Hypertension and Diabetes Mellitus

    • A. Fernandez-Cruz, R. Patiño, J. Ibarra, L. Fernandez, M. Roldan, J. Moya et al.
    Pages 157-170

  15. Endothelium-Dependent Vasodilation in the Peripheral Circulation in Humans In Vivo: Effects of Hypertension and Aging

    • S. Taddei, A. Salvetti
    Pages 171-183

  16. Endothelin and Pulmonary Hypertension

    • D. J. Stewart, D. Langleben
    Pages 184-194

  17. Back Matter

    Pages 195-197
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Keywords

About this book

The endothelium is an important regulator of the cardiovascular system by releasing nitric oxide, prostacyclin, endothelin-1, and other endothelium-derived constricting factors which are able to profoundly affect vascular tone and the function of circulating blood cells such as platelets and monocytes. In addition, the endothelium is a source of factors which can activate or inhibit vascular smooth muscle cell migration and proliferation. Endothelial dysfunction, with an imbalanced production of these factors, therefore, can profoundly affect vascular tone and structure as well as the function of circulating blood cells. Endothelial dysfunction has been demonstrated in various forms of cardiovascular diseasae. Cardiovascular drugs already in clinical use or in development are able to interfere with certain aspects of endothelial function and may be useful in protecting the vessels and, hence, in preventing the development of cardiovascular disease.

Editors and Affiliations

  • Abteilung Kardiologie, Inselspital, Bern, Switzerland

    Thomas F. Lüscher

Bibliographic Information

  • Book Title: The Endothelium in Cardiovascular Disease

  • Book Subtitle: Pathophysiology, Clinical Presentation and Pharmacotherapy

  • Editors: Thomas F. Lüscher

  • DOI: https://doi.org/10.1007/978-3-642-79803-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-642-79805-4Published: 23 December 2011

  • eBook ISBN: 978-3-642-79803-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 197

  • Number of Illustrations: 26 b/w illustrations

  • Topics: Cardiology, Human Physiology, Pharmacology/Toxicology

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