Diuretics

1. Front Matter

   Pages I-XXI

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2. Functional Anatomy of the Kidney

   • B. Kaissling, J. Dørup

   Pages 1-66

3. Basic Concepts of Renal Physiology

   • F. Lang, A. Busch

   Pages 67-114

4. Renal Energy Metabolism

   • W. G. Guder, M. Schmolke

   Pages 115-140

5. Discovery and Development of Diuretic Agents

   • H.-J. Lang, M. Hropot

   Pages 141-172

6. Metabolism of Diuretics

   • W. Möhrke, F. Ullrich

   Pages 173-200

7. Interaction of Diuretics with Transport Systems in the Proximal Renal Tubule

   • K. J. Ullrich

   Pages 201-219

8. Loop Diuretics

   • R. Greger

   Pages 221-274

9. Thiazide Diuretics

   • H. Velázquez, H. Knauf, E. Mutscler

   Pages 275-334

10. Potassium-Retaining Diuretics: Aldosterone Antagonists

    • H. Endou, M. Hosoyamada

    Pages 335-361

11. Potassium-Retaining Diuretics: Amiloride

    • L. G. Palmer, T. R. Kleyman

    Pages 363-394

12. Potassium-Retaining Diuretics: Triamterene

    • T. Netzer, F. Ullrich, H. Knauf, E. Mutschler

    Pages 395-421

13. Osmotic Diuretics: Mannitol

    • O. S. Better, I. Rubinstein, J. Winaver

    Pages 423-441

14. Clinical Uses of Diuretics

    • J. B. Puschett

    Pages 443-505

15. Back Matter

    Pages 507-517

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The first edition of this handbook appeared exactly twenty-five years ago. Due to enormous changes in the area of diuretics, the second edition has had to be completely revised. Substantial progress has been made in the functional anatomy of the kidney and in the concepts of how substances and ions are specifically transported across the various nephron segments. No one could have foreseen twenty-five years ago that the late 1980s and the early 1990s have provided us with methodologies to study transport events not only at the single cell level, but even at the level of the single transporter molecule. Many of the transporters for ions and organic substances have been cloned meanwhile by the new methods of molecular biology, and their function can be described more precisely by new transport studies such as the patch-clamp technique. These new insights have also led to a new understanding of how the currently used diuretics act. Just a few months ago, the Na+Cl- co-transporter, which is the target of thiazides, the Na+2CI-K+ co-transporter, which is the target of furosemide, and the amiloride sensitive Na+ channel were cloned. Hence, the targets of diuretics have now been identified at the molecular level. In addition, during the past twenty-five years extensive studies have been performed on the pharmacokinetics of diuretics. We have learned how changes in liver metabolism and altered renal excretion influence the pharmacology of this class of compounds.

• Clinical Usage
• Diuretics
• Diuretikum
• Hemmstoffe
• Pharmakodynamik
• Pharmakokinetik
• Tabule Transport
• Transport Inhibitors
• drug
• kinetics
• pharmacodynamics
• pharmacokinetics

• Physiologisches Institut, der Albert-Ludwigs-Universität Freiburg, Freiburg, Germany

  Rainer F. Greger

• Medizinische Klinik I Gastroenterologie-Kardiologie-Nephrologie, St. Bernward Krankenhaus Hildesheim, Hildesheim, Germany

  H. Knauf

• Pharmakologisches Institut für Naturwissenschaftler, Biozentrum Niederursel, Frankfurt, Germany

  E. Mutschler

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