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Immediate-Early Genes in the Central Nervous System

  • Book
  • © 1995

Overview

Editors:
  1. T. R. Tölle

    1. Max-Planck-Institut für Psychiatrie Klinisches Institut, Klinische Neuropharmakologie, München, Germany

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  2. J. Schadrack

    1. Max-Planck-Institut für Psychiatrie Klinisches Institut, Klinische Neuropharmakologie, München, Germany

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  3. W. Zieglgänsberger

    1. Max-Planck-Institut für Psychiatrie Klinisches Institut, Klinische Neuropharmakologie, München, Germany

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-vii
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  2. Immediate-early genes — how immediate and why early?

    • G. I. Evan
    Pages 1-17

  3. Immediate-early gene activation as a window on mechanism in the nervous system

    • S. P. Hunt, L. A. McNaughton, R. Jenkins, W. Wisden
    Pages 18-34

  4. Differential expression of immediate-early genes during synaptic plasticity, seizures and brain injury suggests specific functions for these molecules in brain neurons

    • M. Dragunow
    Pages 35-50

  5. Immediate-early genes in nociception

    • T. R. Tölle, J. Schadrack, J. M. Castro-Lopes, W. Zieglgänsberger
    Pages 51-77

  6. A novel face of immediate-early genes: transcriptional operations dominated by c-Jun and Jun D proteins in neurons following axotomy and during regenerative efforts

    • T. Herdegen, S. Brecht, C. E. Fiallos-Estrada, H. Wickert, F. Gillardon, S. Voss et al.
    Pages 78-103

  7. Immediate-early genes and opioid peptides

    • J. Kraus, B. Bacher, X. Wang, V. Höllt
    Pages 104-115

  8. Transgenic mice studies of immediate-early genes: from markers to mutants

    • G. Kasof, T. Curran, J. I. Morgan
    Pages 116-131

  9. Complementary expression patterns of c-jun and jun B in rat brain and analysis of their function with antisense oligonucleotides

    • K.-H. Schlingensiepen, M. Kunst, W. Gerdes, W. Brysch
    Pages 132-145

  10. Characterization and expression of relB, a new member of the rel/NF-κB family of transcription factors

    • R.-P. Ryseck, D. Carrasco, R. Bravo
    Pages 146-159

  11. Back Matter

    Pages 161-166
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Keywords

About this book

Immediate-early genes are believed to be involved in the neuron's ability to con­ vert short-term synaptic stimulation into long-lasting responses and thus contribute to the adaptive alterations involved in neuronal plasticity. Cellular immediate-early genes share a close structural homology with some viral oncogenes. Recent advances in cellular biology have identified the activation and deactivation of immediate-early genes as molecular mechanisms to control regulated and deregulated growth, cellular differentiation and development. In this view immediate-early genes may function as third messengers in a stimulus­ transcription cascade transferring extracellular information into changes in target­ gene transcription, thereby changing the phenotype of neurons. Immediate-Early Genes in the Central Nervous System provides a comprehensive up-to-date overview of current methodology in the research of immediate-early genes and includes a wide range of neurobiological topics, such as regeneration, memory formation, epilepsia and nociception. The contributors to this book have been selected from among the leading experts in their field of research. T.R. TOLLE J. SCHADRACK W. ZIEGLGANSBERGER Contents Immediate-early genes -how immmediate and why early? G./. Evan .............................................. . Immediate-early gene activation as a window on mechanism in the nervous system S.P. Hunt, L.A. McNaughton, R. Jenkins, and W. Wisden. . . . . . . . . .. . . . 18 of immediate-early genes during Differential expression synaptic plasticity, seizures and brain injury suggests specific functions for these molecules in brain neurons M. Dragunow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . 35 . . . . . . . . . .

Editors and Affiliations

  • Max-Planck-Institut für Psychiatrie Klinisches Institut, Klinische Neuropharmakologie, München, Germany

    T. R. Tölle, J. Schadrack, W. Zieglgänsberger

Bibliographic Information

  • Book Title: Immediate-Early Genes in the Central Nervous System

  • Editors: T. R. Tölle, J. Schadrack, W. Zieglgänsberger

  • DOI: https://doi.org/10.1007/978-3-642-79562-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-642-79564-0Published: 19 January 2012

  • eBook ISBN: 978-3-642-79562-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VII, 166

  • Topics: Cell Biology

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