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Molecular Aspects of Oxidative Drug Metabolizing Enzymes

Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health

  • Conference proceedings
  • © 1995

Overview

Editors:
  1. Emel Arinç

    1. Department of Biology, Middle East Technical University, Ankara, Turkey

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  2. John B. Schenkman

    1. Department of Toxicology, University of Connecticut Health Center, Farmington, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Ernest Hodgson

    1. Department of Toxicology, North Carolina State University, Raleigh, USA

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Part of the book series: Nato ASI Subseries H: (ASIH, volume 90)

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Table of contents (29 papers)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. Introduction to Cytochrome P450

    • John B. Schenkman, Ingela Jansson
    Pages 1-19

  3. General Aspects of NADPH Cytochrome P450 Reductase and Cytochrome b5

    • Emel Arinç
    Pages 21-45

  4. Interaction Between Cytochrome P450 and Reductase

    • John B. Schenkman, Andrei I. Voznesensky
    Pages 47-63

  5. Molecular Biology of Cytochrome P-450: Evolution, Structure and Regulation

    • Yoshiaki Fujii-Kuriyama, Osamu Gotoh
    Pages 65-85

  6. The Role of Nuclear Receptors in the Regulation of P450s and Other Genes by Peroxisome Proliferators

    • Eric F. Johnson, Colin N. A. Palmer, Mei-H. Hsu, Keith J. Griffin
    Pages 87-103

  7. Mapping Determinants of the Substrate Specificities of P450s by Site-Directed Mutagenesis

    • Toby H. Richardson, Mei-H. Hsu, Eric F. Johnson
    Pages 105-134

  8. Diversity and Regulation of Cytochromes P450 in Aquatic Species

    • John J. Stegeman
    Pages 135-158

  9. Cytochrome P450 Expression in Rainbow Trout: An Overview

    • Donald R. Buhler
    Pages 159-180

  10. Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity

    • Chung S. Yang, Jun-Yan Hong
    Pages 181-192

  11. Problems Associated with Assessment of the Contribution of Individual Forms of Cytochrome P450 to the Metabolism of Xenobiotics

    • Richard M. Philpot, Lila Overby
    Pages 193-207

  12. Emergence of the Flavin-Containing Monooxygenase Gene Family: Molecular Biology, Structure, and Function

    • Richard M. Philpot, Emmanuel Atta-Asafo-Adjei, Kave Nikbakht, Vicki Burnett, Michael P. Lawton
    Pages 209-224

  13. Flavin-Containing Monooxygenases: Substrate Specificity and Complex Metabolic Pathways

    • Ernest Hodgson, Bonnie L. Blake, Patricia E. Levi, Richard B. Mailman, Michael P. Lawton, Richard M. Philpot et al.
    Pages 225-235

  14. Developmental Regulation of Biotransformation of Drugs and other Xenobiotics

    • Wolfgang Klinger
    Pages 237-248

  15. Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical

    • Chung S. Yang, Theresa J. Smith
    Pages 249-259

  16. Mechanisms of Mutagenicity and Tumour Formation

    • Diana Anderson
    Pages 261-302

  17. Genotoxicity assays

    • Diana Anderson
    Pages 303-396

  18. Use of Mechanistic Information for Adequate Metabolic Design of Genotoxicity Studies and Toxicological Interactions of Drugs and Environmental Chemicals

    • F. Oesch, F. Fähndrich, H. R. Glatt, B. Oesch-Bartlomowicz, K.-L. Platt, D. Utesch
    Pages 397-409

  19. Significance of Posttranslational Modification of Drug Metabolizing Enzymes by Phosphorylation for the Control of Carcinogenic Metabolites

    • F. Oesch, H. J. Arens, F. Fähndrich, T. Friedberg, B. Richter, H. Yamazaki et al.
    Pages 411-427

  20. The Construction of Cell Cultures Genetically Engineered for Metabolic Competence towards Xenobiotics

    • Johannes Doehmer
    Pages 429-454
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Keywords

About this book

Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.

Editors and Affiliations

  • Department of Biology, Middle East Technical University, Ankara, Turkey

    Emel Arinç

  • Department of Toxicology, University of Connecticut Health Center, Farmington, USA

    John B. Schenkman

  • Department of Toxicology, North Carolina State University, Raleigh, USA

    Ernest Hodgson

Bibliographic Information

  • Book Title: Molecular Aspects of Oxidative Drug Metabolizing Enzymes

  • Book Subtitle: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health

  • Editors: Emel Arinç, John B. Schenkman, Ernest Hodgson

  • Series Title: Nato ASI Subseries H:

  • DOI: https://doi.org/10.1007/978-3-642-79528-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-642-79530-5Published: 13 December 2011

  • eBook ISBN: 978-3-642-79528-2Published: 29 June 2013

  • Series ISSN: 1010-8793

  • Edition Number: 1

  • Number of Pages: IX, 614

  • Number of Illustrations: 10 b/w illustrations

  • Topics: Biochemistry, general, Cancer Research, Pharmacology/Toxicology

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