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Tubulointerstitial and Cystic Disease of the Kidney

  • Book
  • © 1995

Overview

Editors:
  1. Susan M. Dodd

    1. The London Hospital Medical College, University of London, London, Great Britain
      Department of Morbid Anatomy, The Royal London Hospital, London, Great Britain

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Part of the book series: Current Topics in Pathology (CT PATHOLOGY, volume 88)

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-XI
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  2. The Pathology of Human Renal Cystic Disease

    • P. D. Wilson, D. Falkenstein
    Pages 1-50

  3. The Pathogenesis of Tubulointerstitial Disease and Mechanisms of Fibrosis

    • S. Dodd
    Pages 51-67

  4. Cellular Biology of Tubulointerstitial Growth

    • G. Wolf, E. G. Neilson
    Pages 69-97

  5. Morphometric Assessment of Tubulointerstitial Damage in Renal Disease

    • R. Sinniah, T. N. Khan
    Pages 99-115

  6. Tubulitis in Renal Disease

    • B. Iványi, S. Olsen
    Pages 117-143

  7. Atubular Glomeruli in Chronic Renal Disease

    • N. Marcussen
    Pages 145-174

  8. The Diabetic Renal Tubulointerstitium

    • F. N. Ziyadeh, S. Goldfarb
    Pages 175-201

  9. Selected Experimental Models of Renal Tubular Atrophy and of Cystic Tubular Cell Hyperplasia

    • H.-J. Gröne
    Pages 203-263

  10. Mechanisms of Renal Damage in Chronic Pyelonephritis (Reflux Nephropathy)

    • J. A. Roberts
    Pages 265-287

  11. Back Matter

    Pages 289-294
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Keywords

About this book

Over recent years, much renal research has focused on the pathology of the glomerulus, where many primary renal insults occur. However, nearly thirty years have passed since Risdon's study made the apparently anomalous observation that the extent of damage to the tubulointerstitial compartment is the major determinant of renal outcome in a variety of human glomerular diseases. This volume covers various aspects of tubulointerstitial disease, and starts with an update on cystic disease of the kidney, by Drs. WILSON and FALKENSTEIN, which includes recent experimental data on the altered properties of cystic epithelium. My own chapter gives an overview of the mechanisms of tubulo­ interstitial damage in progressive renal disease and includes a dis­ cussion of the possible role of cytokines, vasoactive peptides and peptide growth factors found over the last few years to be secreted by renal tubular cells. These comments are expanded in the contribution by Dr. WOLF and Professor NEILSON, who provide a detailed account of the cellular biology of tubulointerstitial growth. The earliest studies from the 19608 attempted to correlate histo­ morphometry of the tubulointerstitium with renal outcome. Dr. KHAN and Professor SINNIAH provide us with an update on mor­ phometric methods as applied to the kidney using new techniques. Similar techniques are employed by Dr. IVANYI and Professor OLSEN who give a detailed stereomorphological account of tubulitis both in acute allograft rejection, where its- recognition is central to the diagnosis, and in other forms of tubulointerstitial disease.

Editors and Affiliations

  • The London Hospital Medical College, University of London, London, Great Britain

    Susan M. Dodd

  • Department of Morbid Anatomy, The Royal London Hospital, London, Great Britain

    Susan M. Dodd

Bibliographic Information

  • Book Title: Tubulointerstitial and Cystic Disease of the Kidney

  • Editors: Susan M. Dodd

  • Series Title: Current Topics in Pathology

  • DOI: https://doi.org/10.1007/978-3-642-79517-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-642-79519-0Published: 22 November 2011

  • eBook ISBN: 978-3-642-79517-6Published: 06 December 2012

  • Series ISSN: 0070-2188

  • Edition Number: 1

  • Number of Pages: XI, 291

  • Topics: Pathology

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