Toxicology in Transition

1. Front Matter

   Pages I-IX

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2. Genetically Modified Cells and Animals in Toxicological Research

   1. Front Matter

      Pages 1-1

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   2. Concepts, Potentials and Methods for Constructing Transgenic Cells and Animals

      • K. Buerki

      Pages 3-7

   3. Use of Recombinant Cells in Metabolic and Mechanistic Studies

      • W. A. Schmalix, J. Doehmer

      Pages 8-22

   4. Applications for Transgenic Animals in Toxicology

      • D. Brusick

      Pages 23-34

3. The Benchmark Dose Concept

   1. Front Matter

      Pages 35-35

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   2. Principles, Benefits and Limitations of the NOEL Approach

      • David J. Esdaile

      Pages 37-43

   3. Comparison of BMD with NOAEL and LOAEL Values Derived from Subchronic Toxicity Studies

      • Rashmi S. Nair, Michel W. Stevens, Mark A. Martens, Jethro Ekuta

      Pages 44-54

4. Bioindicators in Ecotoxicology

   1. Front Matter

      Pages 55-55

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   2. Biomarkers in Ecotoxicology: an Overview

      • J. López-Barea

      Pages 57-79

   3. Use of cytochrome P450 1A (CYP1A) in fish as a biomarker of aquatic pollution

      • Anders Goksøyr

      Pages 80-95

5. Receptor-mediated toxicity

   1. Front Matter

      Pages 97-97

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   2. Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression

      • S. Safe, V. Krishnan

      Pages 99-115

   3. Inhibitors of the Sodium Pump: Toxins, then Drugs, and now hormones

      • J.-D. Horisberger

      Pages 116-124

   4. Rodent Responses To Peroxisome Proliferators — A Receptor-Mediated Phenomenon?

      • J. D. Tugwood

      Pages 125-133

   5. Role of Second Messengers in Mineral Particle-Induced Production of Reactive Oxygen Species by Phagocytes

      • K. Savolainen, M. Ruotsalainen

      Pages 134-147

   6. Estrogenic Effects of Some Xenobiotics

      • M. Vargová, M. Gajdová, J. Jakubovský, L. Wsólová

      Pages 148-152

6. In Vitro tests in regulatory toxicology

   1. Front Matter

      Pages 153-153

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   2. In Vitro Methods in Regulatory Toxicology: The Crucial Significance of Validation

      • M. Balls

      Pages 155-162

   3. Scientific, ethical and legal aspects of the acceptance of in vitro methods in regulatory toxicology

      • E. Walum, B. Forsman, T. Stagh

      Pages 163-169

The volume contains the main papers presented at the 1994 EUROTOX Congress, Basel, Switzerland, August 21-24, 1994. Toxicology has become a less descriptive science because more importance has been placed on the mechanisms underlying toxic effects. This is reflected in symposia and workshops devoted to species differences in organ toxicity, receptor-mediated toxicity and stereochemical effects of xenobiotics. Recent progress in the fields of immunotoxicology, ecotoxicology, and neurotoxicology is highlighted and documented together with the present discussion on harmonized regulatory guidelines.

• chemical carcinogenesis
• chirality
• ecotoxicology
• immunotoxicology
• neurotoxicology
• organ toxicity
• regulatory guidelines
• regulatory toxicology
• toxic effects
• toxicology
• water quality and water pollution

• Institut für Arbeitsphysiologie an der Universität Dortmund, Dortmund, Germany

  Gisela H. Degen

• Interkantonale Kontrollstelle für Heilmittel, Bern 9, Switzerland

  Jürg P. Seiler

• Ciba-Geigy Ltd., Basel, Switzerland

  Philip Bentley

Policies and ethics