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Toxicology in Transition

Proceedings of the 1994 EUROTOX Congress Meeting Held in Basel, Switzerland, August 21–24, 1994

  • Conference proceedings
  • © 1995

Overview

Editors:
  1. Gisela H. Degen

    1. Institut für Arbeitsphysiologie an der Universität Dortmund, Dortmund, Germany

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  2. Jürg P. Seiler

    1. Interkantonale Kontrollstelle für Heilmittel, Bern 9, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  3. Philip Bentley

    1. Ciba-Geigy Ltd., Basel, Switzerland

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Part of the book series: Archives of Toxicology (TOXICOLOGY, volume 17)

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Table of contents (51 papers)

  1. Front Matter

    Pages I-IX
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  2. Genetically Modified Cells and Animals in Toxicological Research

    1. Front Matter

      Pages 1-1
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    2. Concepts, Potentials and Methods for Constructing Transgenic Cells and Animals

      • K. Buerki
      Pages 3-7

    3. Use of Recombinant Cells in Metabolic and Mechanistic Studies

      • W. A. Schmalix, J. Doehmer
      Pages 8-22

    4. Applications for Transgenic Animals in Toxicology

      • D. Brusick
      Pages 23-34

  3. The Benchmark Dose Concept

    1. Front Matter

      Pages 35-35
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    2. Principles, Benefits and Limitations of the NOEL Approach

      • David J. Esdaile
      Pages 37-43

    3. Comparison of BMD with NOAEL and LOAEL Values Derived from Subchronic Toxicity Studies

      • Rashmi S. Nair, Michel W. Stevens, Mark A. Martens, Jethro Ekuta
      Pages 44-54

  4. Bioindicators in Ecotoxicology

    1. Front Matter

      Pages 55-55
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    2. Biomarkers in Ecotoxicology: an Overview

      • J. López-Barea
      Pages 57-79

    3. Use of cytochrome P450 1A (CYP1A) in fish as a biomarker of aquatic pollution

      • Anders Goksøyr
      Pages 80-95

  6. In Vitro tests in regulatory toxicology

    1. Front Matter

      Pages 153-153
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    2. In Vitro Methods in Regulatory Toxicology: The Crucial Significance of Validation

      • M. Balls
      Pages 155-162

    3. Scientific, ethical and legal aspects of the acceptance of in vitro methods in regulatory toxicology

      • E. Walum, B. Forsman, T. Stagh
      Pages 163-169
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Keywords

About this book

The volume contains the main papers presented at the 1994 EUROTOX Congress, Basel, Switzerland, August 21-24, 1994. Toxicology has become a less descriptive science because more importance has been placed on the mechanisms underlying toxic effects. This is reflected in symposia and workshops devoted to species differences in organ toxicity, receptor-mediated toxicity and stereochemical effects of xenobiotics. Recent progress in the fields of immunotoxicology, ecotoxicology, and neurotoxicology is highlighted and documented together with the present discussion on harmonized regulatory guidelines.

Editors and Affiliations

  • Institut für Arbeitsphysiologie an der Universität Dortmund, Dortmund, Germany

    Gisela H. Degen

  • Interkantonale Kontrollstelle für Heilmittel, Bern 9, Switzerland

    Jürg P. Seiler

  • Ciba-Geigy Ltd., Basel, Switzerland

    Philip Bentley

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