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Liver Carcinogenesis

The Molecular Pathways

  • Conference proceedings
  • © 1994

Overview

Editors:
  1. George G. Skouteris

    1. Department of Applied Tumor Virology, Laboratory of Virus-Host Cell Interactions, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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Part of the book series: Nato ASI Subseries H: (ASIH, volume 88)

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Table of contents (30 papers)

  1. Front Matter

    Pages I-XIX
    Download chapter PDF

  2. Molecular Pathways in Hepatocyte Proliferation

    • George G. Skouteris
    Pages 1-11

  3. HGF and Liver Growth Regulation

    • George K. Michalopoulos
    Pages 13-31

  4. Structure, Pleiotropic Actions, and Organotrophic Roles of Hepatocyte Growth Factor

    • Kunio Matsumoto, Toshikazu Nakamura
    Pages 33-53

  5. Hepatocyte Growth Factor and Its Variant with a Deletion of Five Amino Acids are Distinguishable in Biological, Physicochemical, and Immunochemical Properties

    • Nobuyuki Shima, Kanji Higashio
    Pages 55-70

  6. Growth Stimulation Mediated by G Protein Coupled Receptors in Hepatocytes: Synergism with Epidermal Growth Factor and Mechanisms of Signal Transduction

    • Thoralf Christoffersen, G. Hege Thoresen, Olav F. Dajani, Dagny Sandnes, Magne Refsnes
    Pages 71-91

  7. Protein Tyrosine Phosphatases in Signal Transduction

    • Shi-Hsiang Shen, Denis Banville
    Pages 93-108

  8. C-Myc is Essential for Initiation of Dna Synthesis in EGF-Stimulated Hepatocyte Cultures

    • George G. Skouteris
    Pages 109-127

  9. Cellular Biology of the Rat Hepatic Stem Cell Compartment

    • Snorri S. Thorgeirsson, Ritva P. Evarts, Kozo Fujio, Zongyi Hu
    Pages 129-145

  10. Changes in Protein Expression During Oval Cell Proliferation in the Liver

    • T. William Jordan, Irene E. Nickson, Hua Feng
    Pages 147-162

  11. Stem Cell Activation in the Acetylaminofluorene-Treated Regenerating Rat Liver: A Bile Ductular Reaction?

    • T. V. Anilkumar, Matthew Golding, Catherine Sarraf, El-Nasir Lalani, Richard Poulsom, Malcolm Alison
    Pages 163-180

  12. Apoptosis and Its Role in Hepatic Carcinogenesis by Non-Genotoxic Agents

    • R. Schulte-Hermann, W. Bursch, B. Grasl-Kraupp, W. Huber, B. Ruttkay-Nedecky, A. Wagner
    Pages 181-195

  13. Cell Proliferation and Cell Death in the Liver: Patterns, Mechanisms and Measurements

    • Malcolm Alison, Matthew Golding, Catherine Sarraf
    Pages 197-214

  14. Preneoplastic Changes During Non-Genotoxic Hepatocarcinogenesis

    • Christopher J. Powell, Beatrice Secretan, Suzanne Cottrell
    Pages 215-229

  15. mRNA Composition of Rat Liver Tumors Initiated by Aromatic Amines

    • Annette Bitsch, Martina Jost, Hedwig Richter
    Pages 231-247

  16. Liver γ-Glutamyl Transpeptidase Activity after Cyclosporine A and Amlodipine Treatment

    • Jerzy G. Maj, Jeremiasz J. Tomaszewski, Agnieszka E. Haratym
    Pages 249-260

  17. Enhanced Expression of the 27 Da Heat-Shock Protein During Dena-Induced Hepatocarcinogenesis in Rat and in Human Neoplastic and Nonneoplastic Liver Tissues

    • N. Mairesse, M. Delhaye, B. Gulbis, P. Galand
    Pages 261-273

  18. Hepatic Recovery of Dimethylnitrosamine-Cirrhotic Rats after Injection of the Liver Growth Factor

    • Juan J. Diaz-Gil, Carmen Rua, Celia Machin, M. Rosa Cereceda, M. Carmen Guijarro, Pedro Escartin
    Pages 275-285

  19. Cell Contact-Mediated Regulation of Hepatocyte Differentiation/Proliferation: Role of LRP(s)

    • A. Corlu, P. Loyer, S. Cariou, G. P. Ilyin, I. Lamy, M. Corral-Debrinski et al.
    Pages 287-299

  20. Interactions of Human Hepatocytes with Hepatitis B Virus

    • S. Rumin, P. Gripon, M. Corral-Debrinski, J. Cillard, C. Guguen-Guillouzo
    Pages 301-309
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Keywords

About this book

During the last years much attention has been given to the investigation of the roles of specific growth modulators acting on liver cell populations. HGF functions as a pleotropic factor in the liver as well as in other extrahepatic tissues. The hepatic stem cell compartment is thought to play a major role in liver tissue restoration. Mechanisms of cell growth and cell death of the liver are described in detail, with particular emphasis on apoptosis. The functions of HBV-pX protein and the roles of hepatitis B virus gene expression relation to hepatocellular carcinoma are discussed. Techniques for obtaining human and nonhuman hepatocytes and other liver cell types and for efficient transfer and expression of genes in hepatocytes and liver-derived cell lines are presented.

Editors and Affiliations

  • Department of Applied Tumor Virology, Laboratory of Virus-Host Cell Interactions, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    George G. Skouteris

Bibliographic Information

  • Book Title: Liver Carcinogenesis

  • Book Subtitle: The Molecular Pathways

  • Editors: George G. Skouteris

  • Series Title: Nato ASI Subseries H:

  • DOI: https://doi.org/10.1007/978-3-642-79215-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1994

  • Softcover ISBN: 978-3-642-79217-5Published: 27 December 2011

  • eBook ISBN: 978-3-642-79215-1Published: 29 June 2013

  • Series ISSN: 1010-8793

  • Edition Number: 1

  • Number of Pages: XIX, 483

  • Topics: Cancer Research, Cell Biology, Oncology, Human Physiology, Biochemistry, general

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