Toxicology of Metals

1. Front Matter

   Pages I-XXII

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2. Transplacental Transfer of Lead and Cadmium

   • R. A. Goyer

   Pages 1-17

3. Porphyrin Metabolism as Indicator of Metal Exposure and Toxicity

   • J. S. Woods

   Pages 19-52

4. Membrane Transporters as Sites of Action and Routes of Entry for Toxic Metals

   • D. C. Dawson, N. Ballatori

   Pages 53-76

5. Immunotoxicology of Metals

   • L. Pelletier, P. Druet

   Pages 77-92

6. Effects of Metals on Gene Expression

   • J. Koropatnick, M. E. I. Leibbrandt

   Pages 93-120

7. Metallothionein and Its Interaction with Metals

   • M. G. Cherian

   Pages 121-137

8. Biochemical Mechanisms of Aluminum Toxicity

   • E. H. Jeffery

   Pages 139-161

9. Mercury Toxicity

   • K. Miura, A. Naganuma, S. Himeno, N. Imura

   Pages 163-187

10. Toxicology of Cadmium

    • P. L. Goering, M. P. Waalkes, C. D. Klaassen

    Pages 189-214

11. Chromium Toxicokinetics

    • E. J. O’Flaherty

    Pages 215-228

12. Metals and Stress Proteins

    • P. L. Goering, B. R. Fisher

    Pages 229-266

13. Metals and Anticancer Drug Resistance

    • J. S. Lazo

    Pages 267-278

14. Chemistry of Chelation: Chelating Agent Antagonists for Toxic Metals

    • M. M. Jones

    Pages 279-304

15. Therapeutic Use of Chelating Agents in Iron Overload

    • D. M. Templeton

    Pages 305-331

16. Zinc Fingers and Metallothionein in Gene Expression

    • J. Zeng, J. H. R. Kägi

    Pages 333-347

17. Role of Active Oxygen Species in Metal-Induced DNA Damage

    • S. Kawanishi

    Pages 349-371

18. Metal Mutagenesis

    • T. G. Rossman

    Pages 373-405

19. Biological Mechanisms and Toxicological Consequences of the Methylation of Arsenic

    • M. Styblo, M. Delnomdedieu, D. J. Thomas

    Pages 407-433

20. Bacterial Plasmid-Mediated Resistances to Mercury, Cadmium, and Copper

    • S. Silver, M. Walderhaug

    Pages 435-458

The toxicology of metals has been concerned in the past with effects that produced clinical signs and symptoms. However, this view of metal toxicology has expanded in recent years due principally to two advances. There has been a considerable increase in our knowledge of the biochemical effects of metals. In addition, biomarkers of toxicity can now be recognized that identify toxicity at levels of exposure that do not produce overt clinical effects. Thus, the toxicology of metals is now focused on nonclinical events that reflect adverse health effects. This new awareness has produced the challenge of determining the lowest adverse level of exposure. With increasing analytical sensitivity and methodologies to detect small changes at the molecular level, the lowest level of exposure of some toxic metals, like lead, is very small. Indeed, for metals in which there is no biologic requirement, it may be questioned whether there is a level of exposure that does not produce some degree of toxicity. For essential metals, the question is being asked as to the levels at which exposure exceeds biologic require­ ments and excess exposure becomes toxic. The appropriateness of health decisions and the formation of public policy are dependent on the availability of current scientific information that addresses these questions. The information in this volume is intended to be a resource for this purpose as well as a reference for students of toxicology and other health professionals.

• Chelate
• Metal Chelation
• Metalle
• Toxic Metals
• Toxikologie
• chromium
• gene expression
• health effects
• human health
• mercury
• mutagenesis
• poison
• resistance
• toxicity
• toxicology

• Department of Pathology, University of Western Ontario, Canada

  Robert A. Goyer, M. George Cherian

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