Molecular Biology of Mitochondrial Transport Systems

1. Front Matter

   Pages I-XII

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2. Proton Translocation: The Uncoupling Protein and the Atpase

   1. Molecular Studies of the Mitochondrial Uncoupling Protein

      • B. Miroux, A. M. Doulcier-Cassard, L. Casteilla, S. Raimbault, C. Levi-Meyrueis, C. Gelly et al.

      Pages 1-9

   2. Structure-Function Relationship in the Uncoupling Protein of Brown Adipose Tissue

      • M. Klingenberg, E. Winkler

      Pages 11-18

   3. The Gating and Coupling Function of Mitochondrial, H+ ATP Synthase. Role of Fo and F1 Subunits

      • S. Papa

      Pages 19-39

3. Carriers and Transporters

   1. Extension of the Mitochondrial Transporter Family

      • J. E. Walker, M. J. Runswick

      Pages 41-53

   2. The Tricarboxylate Carrier

      • A. Azzi, M. Glerum, R. Koller, W. Mertens

      Pages 55-65

   3. The Mitochondrial Pyruvate Carrier: The Mechanism of Substrate Binding

      • Katarzyna A. Nałęcz

      Pages 67-79

   4. Membrane Topology of the ADP/ATP Carrier from Mitochondria

      • G. Brandolin, G. J. M. Lauquin, R. Brasseur, P. V. Vignais

      Pages 81-97

   5. The Use of Ligand Binding Techniques to Identify Transport Proteins: The Characterization of the [125I]-Iodophenylarsine Oxide Receptor in Rat Mitochondrial Membranes

      • Maureen W. McEnery, Robert D. Hoffman

      Pages 99-116

   6. Channel Properties of Mitochondrial Carriers

      • Thomas Dierks, Reiner Stappen, Reinhard Krämer

      Pages 117-129

4. Mitochondrial ion Channels

   1. A Minimal Kinetic Model of the Activity of the 107 pS Channel of the Inner Membrane of Mitochondria

      • C. Ballarin, M. C. Sorgato, O. Moran

      Pages 131-136

   2. A Channel Model to Explain Regulation of the Mitochondrial Inner Membrane Anion Channel (IMAC)

      • Andrew D. Beavis

      Pages 137-151

   3. The Mitochondrial Permeabilization Pore

      • Mario Zoratti, Ildiko’ Szabo’, Vito De Pinto

      Pages 153-168

   4. Mitochondrial Channels: An Integrated View

      • Kathleen W. Kinnally, Henry Tedeschi

      Pages 169-198

   5. Purification and Patch Clamp Analysis of Two Mitochondrial Channels

      • Joyce J. Diwan, German Costa

      Pages 199-208

   6. The Mitochondrial Outer Membrane Contains at Least Two Distinct Channels

      • M. Thieffry, F. Fèvre, M. Pelleschi, J. P. Henry

      Pages 209-219

   7. ATP-Sensitive K+ Channel in Rat Liver Mitochondria: Functional Characteristics

      • Adam Szewczyk, Stawomir Pikuła, Lech Wojtczak, Maciej J. Nałęczl

      Pages 221-228

5. Structure of the Outer Mitochondrial Membrane Channel, VDAC

   1. Probing for the Voltage Sensor in a Mitochondrial Channel, VDAC, Using Site-Directed Mutagenesis

      • L. Thomas, E. Blachly-Dyson, M. Colombini, M. Forte

      Pages 229-248

   2. Insights Into the Structure of the Mitochondrial Channel, VDAC, Provided by Electron Microscopy

      • Carmen A. Mannella

      Pages 249-263

   3. Experimental Supports to a Sixteen-Strands Model of Transmembrane Arrangement of Mitochondrial Porin and Preliminary Results Concerning a Multigene Family in Drosophila melanogaster Related to Human Mitochondrial Porin

      • Vito De Pinto, Ruggiero Caizzi, Jalal Ahmad Aljamal, Corrado Caggese, Ferdinando Palmieri

      Pages 265-280

Mitochondrial transport systems are essential to mitochondrial function and therefore to energy homeostasis within the cell.
The book contains studies utilizing the techniques of biochemistry, physiology, molecular biology and genetics to reveal the structure and function of mitochondrial transport systems.
It is divided into the following six sections:
- Proton Translocation: The Uncoupling Protein and the ATPase; - Carriers and Transporters; - Mitochondrial Ion Channels; Structure of the Outer Mitochondrial Membrane Channel, VDAC; - VDAC, Peripheral Kinases and Energy Utilization; - Mitochondrial Channels in Humans and Relationship to Disease.

• ATP
• Biomembran
• Mitochondrial Transport Systems
• biochemistry
• biology
• biomembrane
• cell
• chemistry
• genetics
• ion channels
• membrane
• mitochondria
• molecular biology
• physiology
• protein

• Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland, USA

  Michael Forte

• Department of Zoology, University of Maryland, USA

  Marco Colombini

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