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Chromosomal Alterations

Origin and Significance

  • Book
  • © 1994

Overview

Editors:
  1. Günter Obe

    1. Department of Genetics, University of Essen, Essen, Germany

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  2. Adayapalam T. Natarajan

    1. Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Leiden, The Netherlands

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (36 chapters)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Radiation-Induced Formation of DNA Double-Strand Breaks in Plasmids and E. coli

    • D. Schulte-Frohlinde
    Pages 1-9

  3. UV-Induced Pyrimidine Monoadducts and their in vivo Photofootprints

    • R. Drouin, G. P. Holmquist
    Pages 10-20

  4. Chromatin Structure, Hyperthermia and Repair of UV-Induced DNA Photolesions in Mammalian Cells

    • L. H. F. Mullenders, R. J. Sakkers, H. H. Kampinga, A. W. T. Konings
    Pages 21-30

  5. An Inherited Homogeneously Staining Region Derived from a Long-Range Repeat Family in the House Mouse

    • W. Traut, H. Winking, C. Plass, D. Weichenhan, B. Kunze, T. Hellwig et al.
    Pages 31-41

  6. Detection of Genetic Imbalances in Tumor Genomes by Fluorescence in situ Hybridization with Tumor Genomic DNA and Subregional DNA Probes

    • T. Cremer, P. Lichter, S. Popp, E. Schröck, A. Jauch, S. du Manoir et al.
    Pages 42-49

  7. Fluorescent in situ Hybridization (FISH) in Cytogenetical Studies

    • A. T. Natarajan, S. Vermeulen, M. Grigorova, J. J. W. A. Boei, E. T. Sakamoto Hojo, H. J. Oh et al.
    Pages 50-56

  8. The Use of Premature Chromosome Condensation and Chromosome Painting to Understand Chromosome Exchange Formation

    • W. N. Hittelman, D. Wlodek, V. Gregoire, T. K. Pandita
    Pages 57-63

  9. The Role of DNA Double-Strand-Break Rejoining in Chromosome Damage and Repair

    • J. S. King, J. W. Phillips, W. F. Morgan
    Pages 64-75

  10. Investigations of Aberration Origins Using BrdUrd

    • J. R. K. Savage, A. N. Harvey
    Pages 76-91

  11. Elucidation of Some Factors Involved in the Formation of Chromosomal Aberrations by Inhibiting the Repair Polymerase

    • R. C. Moore, C. G. Bingham, M. A. Bender
    Pages 92-102

  12. Use of Antitopoisomerase Drugs to Study the Mechanisms of Induction of Chromosomal Damage

    • F. Palitti, P. Mosesso, D. Dichiara, A. Schinoppi, M. Fiore, L. Bassi
    Pages 103-115

  13. Search for Perturbations induced by X-irradiation in the G2 Phase of Human Lymphocytes

    • G. Mindek, M. Ziehmann
    Pages 116-124

  14. A Comparison of Radiation-Induced Aberrations in Human Cells Involving Early and Late Replicating X-Chromosomes

    • M. C. Mühlmann-Diaz, J. S. Bedford
    Pages 125-131

  15. Radioprotective Chemicals as Tools for Studying Mechanisms of Radiation-Induced Chromosome Damage in Human Lymphocytes

    • L. G. Littlefield, E. E. Joiner, S. P. Colyer, E. L. Frome
    Pages 132-139

  16. Factors Determining the Yields of Radiation-Induced Chromosomal Aberrations as Visualized by Means of Premature Chromosome Condensation in Interphase Cells

    • G. E. Pantelias
    Pages 140-149

  17. Synergism and Adaptive Response in the Interaction of Low Dose Irradiation with Subsequent Mutagenic Treatment in G2 Phase Human Lymphocytes

    • G. Olivieri, A. Bosi, R. Grillo, B. Salone
    Pages 150-159

  18. Responses of Radiosensitive Mutant Mammalian Cell Lines to Restriction Endonuclease induced DNA Double-Strand Breaks

    • P. E. Bryant
    Pages 160-168

  19. Quantitative Localization of Chromatid Breaks Induced by Alu I in the Long Arms of Chromosomes Number 1 of Chinese Hamster Ovary (CHO) Cells by Microphotometric Scanning

    • M. E. Drets, G. A. Folle, W. Martínez, R. Bonomi, J. E. Duarte, B. H. Mechoso et al.
    Pages 169-183

  20. “Life time” of AluI inside Glycerol-Induced Vesicles in CHO Cells

    • C. Johannes, G. Obe
    Pages 184-191
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Keywords

About this book

Due to sensitive molecular biological techniques, our understanding of chromosomal aberrations is steadily increasing. Provided here is a review of basic and applied aspects of the field. Chromosome structure, induction of DNA lesions by different clastogenic agents and their repair, induction of aberrations by agents which affect specific sequences in the DNA, and factors affecting induction and yield of chromosomal aberrations are covered.
Further, topics such as automation of aberration scoring, problems associated with using chromosomal aberrations and micronuclei in population monitoring and the importance of chromosomal aberration assays in mutagenicity testing of chemicals are included.

Editors and Affiliations

  • Department of Genetics, University of Essen, Essen, Germany

    Günter Obe

  • Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Leiden, The Netherlands

    Adayapalam T. Natarajan

Bibliographic Information

  • Book Title: Chromosomal Alterations

  • Book Subtitle: Origin and Significance

  • Editors: Günter Obe, Adayapalam T. Natarajan

  • DOI: https://doi.org/10.1007/978-3-642-78887-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1994

  • Softcover ISBN: 978-3-642-78889-5Published: 19 January 2012

  • eBook ISBN: 978-3-642-78887-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 402

  • Topics: Cell Biology, Zoology, Pharmacology/Toxicology, Human Genetics, Cancer Research

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