Fast Neutrons and High-LET Particles in Cancer Therapy

1. Front Matter

   Pages I-XIII

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2. The Physical Basis for Radiotherapy with Neutrons

   • S. Vynckier, R. Schmidt

   Pages 1-30

3. Specification of Radiation Quality in Fast Neutron Therapy: Microdosimetric and Radiobiological Approach

   • J. Gueulette, H. G. Menzel, P. Pihet, A. Wambersie

   Pages 31-53

4. Relative Biological Effectiveness of Neutrons for Cancer Induction and Other Late Effects: A Review of Radiobiological Data

   • H. Engels, A. Wambersie

   Pages 54-87

5. Neutron Therapy in Malignant Salivary Gland Tumors: Results at European Centers

   • A. Krüll, R. Schwarz, S. Brackrock, R. Engenhart-Cabillic, P. Huber, F. J. Prott et al.

   Pages 88-99

6. European Results of Neutron Therapy in Soft Tissue Sarcomas

   • R. Schwarz, A. Krüll, A. Lessel, R. Englenhart-Cabillic, A. Favre, F. J. Prott et al.

   Pages 100-112

7. Use of Neutron Therapy in the Management of Locally Advanced Nonresectable Primary or Recurrent Rectal Cancer

   • R. Engenhart-Cabillic, J. Debus, F. J. Prott, R. Pötter, K. H. Höver, N. Breteau et al.

   Pages 113-124

8. Fast Neutrons in Prostatic Adenocarcinomas: Worldwide Clinical Experience

   • K. L. Lindsley, P. Cho, K. J. Stelzer, W.-J. Koh, M. Austin-Seymour, K. J. Russell et al.

   Pages 125-136

9. The Role of Fast Neutrons in the Treatment of Squamous Cell Carcinomas of the Head and Neck: The European Experience

   • T. Auberger, W. Reuschel

   Pages 137-147

10. Sacrococcygeal Chordomas: Potential Role of High-LET Therapy

    • N. Breteau, M. Demasure, J. Lescrainier, R. Sabbattier, P. Michenet

    Pages 148-155

11. Complications of Fast Neutron Therapy

    • L. Cohen

    Pages 156-169

12. Is There a Role for Heavy Ion Beam Therapy?

    • J. Debus, O. Jäckel, G. Kraft, M. Wannenmacher

    Pages 170-182

13. Boron Neutron Capture Therapy: Principles and Potential

    • R. Gahbauer, N. Gupta, T. Blue, J. Goodman, R. Barth, J. Grecula et al.

    Pages 183-209

14. Back Matter

    Pages 210-218

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Fast neutron therapy was introduced in London in 1970. The book gives an overview of the developments of the past 28 years, assesses the results of fast neutron treatment, and reviews the compiled clinical data worldwide. The authors describe the radiobiological profile of the neutron beams and evaluate the neutron RBE for secondary cancer induction, they introduce heavy-ion therapy, which combines high physical selectivity with the biological advantages of high-LET radiation for some tumor types, and finally they describe the very recent developments in Boron Neutron Capture Therapy (BNCT).

• Radiobiologie
• Therapie mit schweren Ionen
• Tumor
• cancer
• cancer therapy
• carcinoma
• cell
• heavy-ion therapy
• radiation
• radiobiology
• radiotherapy

• Medizinisches Zentrum für Radiologie Abteilung für Strahlentherapie, Universität Marburg, Marburg, Germany

  Rita Engenhart-Cabillic

• Cliniques Universitaires St.-Luc, Université Catholique de Louvain, Bruxelles, Belgium

  André Wambersie

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