Soft Tissue Sarcomas in Adults

1. Front Matter

   Pages I-XI

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2. Diagnostic Workup of Soft Tissue Sarcomas

   1. Imaging of Soft Tissue Sarcomas

      • M. F. Ensign

      Pages 1-11

   2. Classification, Grading, and Staging of Soft Tissue Sarcomas

      • P. Meister

      Pages 13-16

   3. Immunohistochemistry in Diagnosis of Soft Tissue Sarcomas and New Techniques in Soft Tissue Tumour Pathology

      • C. D. M. Fletcher

      Pages 17-24

   4. Surgical Biopsy Techniques and Differential Diagnosis of Soft Tissue Tumours

      • J. M. Thomas

      Pages 25-29

3. Local Treatment of Soft Tissue Sarcomas

   1. Limb Salvage and Reconstructive Procedures in Soft Tissue Sarcomas of the Extremities

      • H. U. Steinau, R. Büttemeyer, P. Vogt, J. Hussmann, D. Hebebrand

      Pages 31-39

   2. Surgical Management of Truncal and Head/Neck Soft Tissue Tumours

      • J. M. Thomas

      Pages 41-45

   3. Combined Surgery and Radiotherapy for Conservative Management of Soft Tissue Sarcomas

      • E. B. Hug, I. J. Spiro, D. J. Cole, H. D. Suit

      Pages 47-55

   4. Role of Brachytherapy in the Treatment of Soft Tissue Sarcomas of the Extremities — Techniques and Results

      • D. Nori, B. S. Hilaris

      Pages 57-71

   5. Radiotherapy in the Treatment of Inoperable and Advanced Soft Tissue Sarcomas in Adults

      • M. Bamberg, H. Schmidberger, W. Hoffmann

      Pages 73-79

   6. Regional Hyperthermia Combined with Systemic Chemotherapy of Locally Advanced Sarcomas: Preclinical Aspects and Clinical Results

      • R. D. Issels

      Pages 81-90

4. Local Recurrences and Disseminated Disease

   1. Histological Characteristics of Local Recurrences in Soft Tissue Sarcomas

      • C. D. M. Fletcher

      Pages 91-94

   2. Local Recurrences of Soft Tissue Sarcomas — A Therapeutic Challenge

      • V. Budach, M. Stuschke, W. Budach

      Pages 95-108

   3. Histomorphological Characteristics of Metastases of Soft Tissue Sarcomas

      • D. Schmidt

      Pages 109-116

   4. Radiotherapy in the Treatment of Metastases of Soft Tissue Sarcomas

      • W. Hoffmann, R. D. Kortmann, M. Bamberg

      Pages 117-121

   5. Results of Surgical Treatment of Pulmonary Metastases from Soft Tissue Sarcomas

      • J. Schirren, S. Krysa, H. Bülzebruck, A. Zweibarth, P. Schneider, P. Drings et al.

      Pages 123-138

5. Systemic Treatment

   1. Adjuvant Chemotherapy of Soft Tissue Sarcomas in North America

      • R. S. Benjamin

      Pages 139-145

   2. Systemic Therapy of Disseminated Soft Tissue Sarcomas

      • H. J. Weh, D. K. Hossfeld

      Pages 147-159

6. New Developments and Future Aspects

   1. Isolation Perfusion with Tumor Necrosis Factor-α, Interferon-γ, and Hyperthermia in the Treatment of Localized and Metastatic Cancer

      • J. C. Yang, D. L. Fraker, A. K. Thom, H. I. Pass, S. A. Rosenberg

      Pages 161-166

   2. Radiosensitivity and Local Tumor Control — Experimental Studies

      • V. Budach, M. Stuschke, W. Budach

      Pages 167-171

Sarcomas represent a group of rare tumors which arise from the largest tissue compartment of the body, but account only for about 1 % of all malignancies. Among this group of tumors, soft tissue sarcomas in adults are, in addition to osteosarcomas, the most important. In the diagnostic workup of soft tissue sarcomas modern radiological investigation methods such as CT and MRI techniques are being critically evaluated. While it is widely accepted that the conventional, stained microscopic specimen is still the cornerstone for properly planned treatment stra­ tegies, immunohistochemistry has come to play an indis­ pensable role in accurate classification. Reviewing the surgical techniques, the treatment of musculo-skeletal malignancies, especially of soft tissue sarcomas, has changed considerably over the past decades. While amputation used to be the surgical treatment of choice limb-saving procedures have now become an im­ portant therapeutic modality in treating such lesions, particularly in combination with percutaneous or interstitial radiotherapy. Despite adequate local treatment, many patients with soft tissue sarcomas will ultimately develop metastatic disease, usually in the lungs. For this reason, effective ad­ juvant systemic treatment should be given simultaneously with or soon after treatment of local disease. The results of several randomized trials evaluating adjuvant chemotherapy have been reported in the meanwhile, indicating im­ proved, disease-free survival with a trend towards improved overall survival. In disseminated disease, drug combi- VI Preface nations or single agents are used as palliative treatment and might help to improve survival in selected subgroups.

• Grading
• Staging
• biopsy
• brachytherapy
• cancer
• classification
• cytogenetics
• genetics
• imaging techniques
• pathology
• radiotherapy
• surgery
• systemic therapy
• tissue
• tumor

• Department of Radiotherapy, University of Tübingen, Tübingen, Germany

  M. Bamberg, W. Hoffmann

• Department of Hematology and Oncology, University of Hamburg, Hamburg, Germany

  D. K. Hossfeld

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