Dupuytren’s Disease

1. Front Matter

   Pages I-XVIII

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2. Morphology

   1. Front Matter

      Pages 1-1

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   2. Morphology of Dupuytren’s Disease

      • W. Mohr, D. Wessinghage

      Pages 3-15

   3. Interactions Between Proteoglycans and Collagen Fibrils in the Palmar Fascia in Dupuytren’s Disease

      • G. Brandes, E. Reale, P. Brenner, T. Körner

      Pages 16-23

   4. Myofibroblasts Are Not Specific to Dupuytren’s Disease

      • G. A. C. Murrell, M. J. O. Francis, C. R. Howlett

      Pages 24-33

   5. The Significance of Skin Anchoring Fibres in Palmar Fibrosis: Brief Comment

      • A. Meinel

      Pages 34-34

3. Pathobiochemistry of Fibrillar Component

   1. Front Matter

      Pages 35-35

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   2. Collagen Changes in Dupuytren’s Disease

      • A. J. Bailey

      Pages 37-48

   3. Connective Tissue Autoantibodies in Dupuytren’s Disease: Associations with HLA DR3

      • E. J. Menzel, J. Neumüller, A. Rietsch, H. Millesi

      Pages 49-61

   4. Collagen Production by Cultured Dupuytren’s Fibroblasts

      • G. A. C. Murrell, M. J. O. Francis

      Pages 62-69

4. Proteoglycans and Glycosaminoglycans

   1. Front Matter

      Pages 71-71

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   2. Proteoglycans in Biopsies of Dupuytren’s Contracutre

      • E. Gurr, M. Borchert, W. Borchert, A. Delbrück

      Pages 73-84

   3. Glycosaminoglycan Distribution Pattern in Dupuytren’s Contracture Biopsies

      • N. Gässler

      Pages 85-93

   4. Biochemical Parameters for the Diagnosis of Dupuytren’s Disease

      • N. Gässler, P. Brenner, A. Berger, A. Delbrück

      Pages 94-98

5. Pathobiochemistry of Cells in Dupuytren’s Contracture

   1. Front Matter

      Pages 99-99

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   2. Investigations of Cell Cultures Derived from Patients Suffering from Dupuytren’s Contracture

      • J. Neumüller

      Pages 101-110

   3. Fibroblast Gel Culture: A Model for Biochemical Investigations of Dupuytren’s Contracture

      • A. Delbrück, H. Schröder

      Pages 111-116

   4. Reactivity of Cells in Nodules of Dupuytren’s Contracture with Monoclonal Antibodies Recognizing Leukocyte Antigens and von Willebrand’s Factor

      • C. Sachse, P. Brenner

      Pages 117-126

   5. Demonstration of Myofibroblasts Using a Novel Murine Monoclonal Antibody, 3C2G10.7 Raised from Proliferating Cells in Dupuytren’s Disease

      • D. T. Shum, G. Pringle, B. Hasegawa, J. S. Botz, R. M. McFarlane

      Pages 127-138

   6. Reactivity of Nodular Cells in Vitro: A Guide to the Pharmacological Treatment of Dupuytren’s Contracture

      • I. L. Naylor, D. J. Coleman, R. A. Coleman, S. E. Cross, I. T. H. Foo

      Pages 139-150

In this volume a distinguished group of internationally renowned clinicians and basic researchers discuss the present state of knowledge of the etiologyand pathogenesis of Dupuytren's contracture, a disease responsible for a considerable portion of disabilities within the working population allover the world. Although the riddle of how the contracture of the palmar fascia develops is still unsolved, the data on the pathobiochemistry and clinic of Dupuytren's Disease achieved in recent years has led to a better understanding of the biochemical and morphological processes underlying the deformation and malfunction of the afflicted tissues. Research in Dupuytren's Disease now enters the era of molecular medicine, which opens up new experimental means of studying the pathological changes which occur during the formation of the contracture on a molecular level. In particular, data are presented as to the role of specific biological macromolecules influencing the phenotype expression of the palmar fascia cells which are involved in autoimmune reactions and present both at the cell surface as well as in the extracellular matrix to regulate cell-to-cell and cell-to-matrix interactions. In vitro cell culture models to investigate fibro-cytic modulations are available and havebeen applied to study the effects of specific biological molecules on isolated cells from healthy palmar fascia and Dupuytren's contracture. Complementary evaluations of morphological, epidemiological, and clinical data contribute essentially to the present understanding of the etiology and pathogenesis of Dupuytren's Disease. This comprehensive and informative summary of the state of the art is completed by numerous references affixed to the individual contributions.

• Aetiology
• Cellular Biology
• Dupuytren's Disease
• Extrazelluläre Matrix
• Histopathologie
• Histopathology
• Immunhistochemie
• Immunochemistry
• biochemistry
• chemistry
• phenotype

• Klinik für Plastische, Hand- und Wiederherstellungschirurgie, Krankenhaus Oststadt, Medizinische Hochschule Hannover, Hannover, Germany

  Alfred Berger, Peter Brenner

• Institut für Klinische Chemie II, Krankenhaus Oststadt, Medizinische Hochschule Hannover, Hannover, Germany

  Axel Delbrück, Rolf Hinzmann

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