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Acute Leukemias IV

Prognostic Factors and Treatment Strategies

  • Conference proceedings
  • © 1994

Overview

Editors:
  1. T. Büchner

    1. Department of Internal Medicine, Germany

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  2. W. Hiddemann

    1. Department of Internal Medicine, University of Göttingen, Göttingen, Germany

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  3. B. Wörmann

    1. Department of Internal Medicine, University of Göttingen, Göttingen, Germany

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  4. G. Schellong

    1. Department of Pediatrics, University of Münster, Münster, Germany

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  5. J. Ritter

    1. Department of Pediatrics, University of Münster, Münster, Germany

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Part of the book series: Haematology and Blood Transfusion Hämatologie und Bluttransfusion (HAEMATOLOGY, volume 36)

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Table of contents (148 papers)

  1. Front Matter

    Pages I-XXXVI
    Download chapter PDF

  2. The Treatment of Acute Leukemia: Observations by a Marrow Transplanter

    1. The Treatment of Acute Leukemia: Observations by a Marrow Transplanter

      • E. D. Thomas
      Pages 1-5

  3. Leukemia Cell Biology

    1. Front Matter

      Pages 7-7
      Download chapter PDF

    2. Polymerase Chain Reaction Approach for the Evaluation of Minimal Residual Disease in Acute Leukemia

      • A. Biondi, C. R. Bartram, A. Rambaldi, V. Rossi, A. Luciano, M. Cavana et al.
      Pages 9-14

    3. Two Subtypes of Therapy-Related Leukemia; Experience from The Copenhagen Series

      • J. Pedersen-Bjergaard, P. Philip, S. O. Larsen, M. Andersson, G. Daugaard, J. Ersbøll et al.
      Pages 15-23

    4. Incidence, Biologic Features and Treatment Outcome of Myeloid-Antigen-Positive Acute Lymphoblastic Leukemia (My + ALL)

      • W. D. Ludwig, J. Harbott, H. Rieder, C. R. Bartram, J. Maurer, R. Becher et al.
      Pages 24-32

    5. In Situ Amplification of Rearranged Gene Sequences in Individual Cells for Tracing Clonal Cells in Smears from Blood and Bone Marrow

      • K. Pachmann, W. Spann, H. Zabnienska, M. Knizia, B. Emmerich
      Pages 33-37

    6. Detection of Chromosomal Abnormalities on Previously Stained Peripheral Blood and Bone Marrow Smears

      • M. Bentz, H. Döhner, M. Schröder, S. Pohl, P. Lichter
      Pages 38-42

    7. Interphase Cytogenetics of Childhood Acute Lymphoblastic Leukemia with Fluorescence In Situ Hybridization Using a Panel of Eight Chromosome-Specific DNA Probes

      • A. Berger, S. Strehl, P. F. Ambros, O. A. Haas, H. Gadner
      Pages 43-46

    8. Identification and Characterization of Monoclonal Lymphoid Populations by Analysis of Complementary RNA of Clonespecific DNA Sequences

      • O. M. Koch, M. Volkenandt, E. Göker, J. Buer, R. Wienecke, D. Banerjee et al.
      Pages 47-50

    9. Differences in Immunoglobulin and T-Cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemia Between Diagnosis and Relapse

      • A. Beishuizen, M-A. J. Verhoeven, K. Hählen, E. R. van Wering, J. J. M. van Dongen
      Pages 51-58

    10. Characterization of Clonal Gene Rearrangements for the Detection of Residual Leukemic Disease in Acute Lymphoblastic Leukemia

      • F. Griesinger, H. Elfers, B. Wörmann, J. Ritter, T. Büchner, J. van de Loo et al.
      Pages 59-64

    11. Analysis of Variable Number of Tandem Repeats Reveals Differences Between Leukemic Cells and Remission Phase Leukocytes

      • G. Hübner, K. Battmer, H. Poliwoda, H. Link
      Pages 65-70

    12. The tal-1 Gene Rearrangement in Acute Lymphoblastic Leukemia

      • A. Borkhardt, R. Repp, J. Harbott, C. Keller, F. Lampert
      Pages 71-74

    13. Significance of Lineage-Associated Transcripts of TdT and ETS1 for Detection of Leukemic Cells

      • C.-M. Wendtner, N. Sacchi, T. Büchner, W. Hiddemann, J. van de Loo, B. Wörmann
      Pages 75-80

    14. Mutations of the P53 Gene in Acute Leukemias: A Report on 207 Cases

      • C. Preudhomme, I. Quiquandon, P. Jonveaux, J. L. Laï, M. Vanrumbeke, M. H. Loucheux-Lefebvre et al.
      Pages 81-84

    15. Regulation of the Expression of ICAM-1 on Pre-B Cell Lines by TNF-α and IFN-γ

      • C. Schardt, C. Schardt, H. G. Drexler, A. Ganser, D. Hoelzer
      Pages 85-89

    16. Modulation of Adhesion Molecules in Patients with AML During Immunotherapy with IL-2

      • K. Fenchel, L. Bergmann, B. Jahn, P. S. Mitrou
      Pages 90-95

    17. Frequency of Aberrant Surface Marker Expression in 221 Cases of Adult Acute Leukemia: An Immunologic/Cytogenetic Analysis

      • C. Tirier, R. Becher, W. Heit
      Pages 96-101

    18. Elevated Plasma Neuropeptide Y as a Marker of B Cell Precursor Leukemia in Children

      • P. Kogner, A. Ericsson, G. Barbany, H. Persson, E. Theodorsson, O. Björk
      Pages 102-105
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Keywords

About this book

The rates of acute leukemia cure have gradually improved over the last decade. Clinical study results reflect the impact of chemotherapy intensity and duration, the role of prolonged maintenance, intensified consolidation or very early intensification. Further progress has also been achieved in bone marrow trans­ plantation, and recent prospective studies and meta-analyses have contributed comparisons of the high antileukemic efficacy of bone marrow transplantation to that of improved chemotherapy. This allows a more successful combining of the two forms of treatment. New prognostic factors have emerged from both cytogenetic and molecular genetic research. Thus, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have proven to be the dominating risk factor in acute lymphoblastic leukemia. Since the frequency increases with age, differences in prognosis between children and adults can be explained. Evaluation of molecular and immunologic leukemia cell markers has provided a better understanding of residual leukemia in clinical remission, as a prognostic factor and in monitoring the effectiveness of the antileukemic strategy. Recent work on leukemic cell biology has resulted in novel therapeutic approaches such as terminal differentiation by all-trans-retinoic acid, modulation of chemotherapy by hematopoietic growth factors such as GM-CSF and enhancement of immunologic control by cytokines such as interleukin 2. New antimicrobial drugs and the application of mostly empiric anti-infectious strategies have helped reducing the therapeutic risk. Thus, a number of recent achievements have provided us with new options in the management of patients with acute leukemias.

Editors and Affiliations

  • Department of Internal Medicine, Germany

    T. Büchner

  • Department of Internal Medicine, University of Göttingen, Göttingen, Germany

    W. Hiddemann, B. Wörmann

  • Department of Pediatrics, University of Münster, Münster, Germany

    G. Schellong, J. Ritter

Bibliographic Information

  • Book Title: Acute Leukemias IV

  • Book Subtitle: Prognostic Factors and Treatment Strategies

  • Editors: T. Büchner, W. Hiddemann, B. Wörmann, G. Schellong, J. Ritter

  • Series Title: Haematology and Blood Transfusion Hämatologie und Bluttransfusion

  • DOI: https://doi.org/10.1007/978-3-642-78350-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1994

  • Softcover ISBN: 978-3-642-78352-4Published: 05 December 2011

  • eBook ISBN: 978-3-642-78350-0Published: 06 December 2012

  • Series ISSN: 0440-0607

  • Edition Number: 1

  • Number of Pages: XXXVI, 803

  • Topics: Hematology, Oncology, Pediatrics

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