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Ataxia-Telangiectasia

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Richard A. Gatti

    1. Department of Pathology, University of California Los Angeles School of Medicine, Los Angeles, USA

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  2. Robert B. Painter

    1. Laboratory of Radiobiology and Environmental Health, University of California San Francisco, San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Nato ASI Subseries H: (ASIH, volume 77)

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Table of contents (23 papers)

  1. Front Matter

    Pages I-XXIII
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  2. Introduction

    1. Front Matter

      Pages XIX-XIX
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    2. Ataxia-Telangiectasia: A Brief Historical Overview

      • Robert P. Sedgwick
      Pages 1-3

  3. Isolation of A-T Gene(s)

    1. Front Matter

      Pages 5-5
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    2. Cloning and Characterization of a Candidate Gene for A-T Complementation Group D

      • Leon N. Kapp, John P. Murnane
      Pages 7-22

    3. Precise Localization of a Gene Responsible for Ataxia-Telangiectasia on Chromosome 11q

      • F. Cornélis, M. James, D. Cherif, T. Tokino, J. Davies, D. Girault et al.
      Pages 23-35

    4. How Many Ataxia-Telangiectasia Genes?

      • Ethan Lange, Richard A. Gatti, Eric Sobel, Patrick Concannon, Kenneth Lange
      Pages 37-54

    5. Isolation of Human cDNAS That Complement the Ataxia-Telangiectasia Phenotype in Cultured Fibroblasts

      • M. Stephen Meyn, Jennifer M. Lu-Kuo, Laura B. K. Herzing
      Pages 55-64

    6. Complementation of the Cellular A-T Phenotype by Gene Transfer

      • Yael Ziv, Tsafi Danieli, Galit Rotman, Adam Sartiel, Anat Bar-Shira, N. G. J. Jaspers et al.
      Pages 65-74

    7. Use of Microcell Hybrids for Analysis of the 11q23 Region and Improved Localization of the A-T Group A/C Genes

      • Y. Ejima, M. Oshimura, M. S. Sasaki
      Pages 75-85

    8. AT-like Radiosensitive Rodent Cell Mutants: An Alternative Approach to the Isolation of the A-T Gene(s)

      • M. Z. Zdzienicka, G. W. C. T. Verhaegh, W. Jongmans, N. G. J. Jaspers, M. Oshimura, M. R. James et al.
      Pages 87-97

  4. A-T Heterozygotes and Complementation

    1. Front Matter

      Pages 99-99
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    2. Identification of A-T heterozygotes

      • D. Scott, L. A. Jones, S. A. G. Elyan, A. Spreadborough, R. Cowan, G. Ribiero
      Pages 101-116

    3. Correction of Post-γ Ray DNA Repair Deficiency in Ataxia-Telangiectasia Complementation Group A Fibroblasts by Cocultivation with Normal Fibroblasts

      • M. C. Paterson, R. Mirzayans
      Pages 117-126

    4. The A-T gene does not make a major contribution to familial breast cancer

      • Richard Wooster, Douglas F. Easton, Deborah Ford, Jonathan Mangion, Bruce A. J. Ponder, Julian Peto et al.
      Pages 127-135

    5. Mammography Screening for A-T Heterozygotes

      • Amos Norman, H. Rodney Withers
      Pages 137-140
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Keywords

About this book

Ataxia-telangiectasia or A-T is a fatal progressive neurological disease of children. The symptoms indicate disruptions in the development of such diverse body parts as cerebellum, thymus and chromosomes. The patients are unduly sensitive to ionizing radiation, immunodeficient, and a third of them develops cancer. All of this stems from defects of a single gene. Provided here is an up-to-date review of all important work in thefield. A wide spectrum of topics is covered, namely genetics, chromosome 11 mapping, radiobiology, complementation, heterozygote identification, clinical variants, biochemistry, and treatment of A-T.

Editors and Affiliations

  • Department of Pathology, University of California Los Angeles School of Medicine, Los Angeles, USA

    Richard A. Gatti

  • Laboratory of Radiobiology and Environmental Health, University of California San Francisco, San Francisco, USA

    Robert B. Painter

Bibliographic Information

  • Book Title: Ataxia-Telangiectasia

  • Editors: Richard A. Gatti, Robert B. Painter

  • Series Title: Nato ASI Subseries H:

  • DOI: https://doi.org/10.1007/978-3-642-78278-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-642-78280-0Published: 23 June 2012

  • eBook ISBN: 978-3-642-78278-7Published: 29 June 2013

  • Series ISSN: 1010-8793

  • Edition Number: 1

  • Number of Pages: XXIII, 283

  • Number of Illustrations: 18 b/w illustrations

  • Topics: Pathology, Human Genetics, Oncology, Immunology, Cancer Research

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