GTPases in Biology I

1. Front Matter

   Pages I-XLIII

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2. Biological Importance of GTPase-Driven Switches

   1. Front Matter

      Pages 1-1

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   2. GTPases Everywhere!

      • H. R. Bourne

      Pages 3-15

   3. Proofreading in the Elongation Cycle of Protein Synthesis

      • E. Bergmann, F. Jurnak

      Pages 17-30

   4. A New Look at Receptor-Mediated Activation of a G-protein

      • L. Birnbaumer

      Pages 31-38

   5. Small GTPases and Vesicle Trafficking: Sec4p and its Interaction with Up- and Downstream Elements

      • P. Novick, P. Brennwald

      Pages 39-52

   6. Cytoskeletal Assembly: The Actin and Tubulin Nucleotidases

      • M.-F. Carlier, D. Pantaloni

      Pages 53-62

   7. Dynamin, A Microtubule-Activated GTPase Involved in Endocytosis

      • R. B. Vallee, J. S. Herskovits, C. C. Burgess

      Pages 63-73

   8. Transmembrane Protein Translocation: Signal Recognition Particle and Its Receptor in the Endoplasmic Reticulum

      • P. J. Rapiejko, R. Gilmore

      Pages 75-85

   9. GTPases and Actin as Targets for Bacterial Toxins

      • K. Aktories, I. Just

      Pages 87-112

3. Structures of the GTPase Switches

   1. Front Matter

      Pages 113-113

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   2. Eukaryotic Translation Factors Which Bind and Hydrolyze GTP

      • J. Cavallius, W. C. Merrick

      Pages 115-130

   3. Heterotrimeric G-Proteins: α, β, and γ Subunits

      • H. Itoh, Y. Kaziro

      Pages 131-149

   4. Molecular Diversity in Signal Transducing G-Proteins

      • L. Birnbaumer

      Pages 151-158

   5. Structural Conservation of Ras-Related Proteins and Its Functional Implications

      • P. Chardin

      Pages 159-176

   6. Conformational Switch and Structural Basis for Oncogenic Mutations of Ras Proteins

      • S.-H. Kim, G. G. Privé, M. V. Milburn

      Pages 177-194

   7. Structural and Mechanistic Aspects of the GTPase Reaction of H-ras p21

      • A. Wittinghofer, E. F. Pai, R. S. Goody

      Pages 195-211

   8. Analysis of Ras Structure and Dynamics by Nuclear Magnetic Resonance

      • S. L. Campbell-Burk, T. E. Van Aken

      Pages 213-234

   9. Molecular Dynamics Studies of H-ras p21-GTP

      • C. K. Foley, L. G. Pedersen, T. A. Darden, P. S. Charifson, A. Wittinghofer, M. W. Anderson

      Pages 235-245

4. Small Ras-Related GTpases

   1. Front Matter

      Pages 247-247

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Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches utilized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life itself, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become the reference work for GTPases.

• Calcium
• DNA
• Nucleotide
• RNA
• biochemistry
• biology
• gene expression
• membrane transport
• metabolism
• molecular biology
• mutation
• protein
• protein synthesis
• proteins
• translation

• Department of Medicine, Cell Biology and Experimental Therapeutics, Room 3C-385, Houston VA Medical Center, Baylor College of Medicine, Houston, USA

  Burton F. Dickey

• Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, Houston, USA

  Lutz Birnbaumer

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