Overview
- Editors:
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Eugenio E. Müller
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Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
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Daniela Cocchi
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Pharmaco-biological Institute, University of Bari, Bari, Italy
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Vittorio Locatelli
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Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
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Table of contents (28 papers)
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Growth Hormone
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- V. Locatelli, S. G. Cella, D. Cocchi, V. Gennaro De Colonna, E. Giavini, M. Parenti et al.
Pages 3-18
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- N. Katsumata, C. Chakraborty, H. G. Friesen
Pages 19-25
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- M. J. Waters, S. W. Rowlinson, K. S. Gobius, P. E. Lobie, J. Garcia-Aragon, G. E. Muscat et al.
Pages 26-43
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- G. Norstedt, C. Carter-Su, S. Enerbäck, B. Enberg, G. Bjursell, S. Francis et al.
Pages 44-51
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Somatomedins
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- M. L. Adamo, D. LeRoith, C. T. Roberts Jr.
Pages 55-64
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- J. Isgaard, A. Nilsson, C. Ohlsson, A. Lindahl, H. Wåhlander, P. Friberg et al.
Pages 65-71
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- P. Nissley, W. Lopaczynski
Pages 72-87
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- J. M. Ketelslegers, J. P. Thissen, D. Maiter, T. Fliesen, T. Mauerhoff, S. Triest et al.
Pages 88-99
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- F. Minuto, A. Barreca, G. Giordano
Pages 117-128
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Fetal and Neonatal Growth
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Front Matter
Pages 129-129
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- L. A. Frohman, T. R. Downs, M. Sato
Pages 131-140
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- V. R. Sara, C. Ayer-Le Lievre, C. Carlson-Skwirut, K. Drakenberg, M. B. Giacobini, L. Olson et al.
Pages 141-146
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- P. D. Gluckman, J. E. Harding, M. H. Oliver, L. Liu, G. R. Ambler, M. Klempt et al.
Pages 147-160
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- P. Czernichow, R. Rappaport
Pages 161-170
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Plenary Lecture
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Front Matter
Pages 171-171
About this book
The various congresses on growth hormone (GH) which have been held in Milan since 1967, the Milan Congresses, have witnessed over 25 years the tremendous expansion of a research field that was based initially upon the scarce knowledge of the biological properties of a protein. GH, whose chemical structure had just been identified and a radioimmunoassay developed for its measurement in blood, became in the following years a major area of biological research. The boundaries have since become blurred, as the research area has extended to the physiology and pathology of growth, puberty and reproduction, and the control of metabolism during the whole lifespan. Since the last GH Congress held in 1987, GH studies using the molecular biological approach have resulted in the puri fication, cloning and expression of the human GH (hGH) recep tor and binding protein, in new and exciting information on the insulin-like growth factors (IGF) and their paracrine and autocrine roles, and in the awareness that a panoply of binding proteins are present in the extracellular fluids and can, possibly, modulate IGF-receptor interactions and, thus, IGF actions. Finally, the availability of large amounts of biosynthetic hGH, besides allow ing more extensive clinical use in states of GH deficiency and extrasomatotrophic pathologies, has permitted disclosure of im portant metabolic effects of hGH during adulthood and, perhaps, aging and in many protein catabolic states.
